A study on otoacoustic emissions and supression effects in patients with Vitiligo

Angrisani, Rosanna Mariangela Giaffredo; Azevedo, Marisa Frasson de; Pereira, Liliane Desgualdo; Lopes, Celso; Garcia, Michele Vargas

doi:10.1016/s1808-8694(15)30841-7

Cited by 23 publications

(27 citation statements)

References 15 publications

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“…In the present study patients with vitiligo had remarkably reduced SNR of DPOAEs and TOAEs as compared to the control group. Angrisani et al [20] reported that 66.7 % of their vitiligo patients (n = 21) had no OAEs, suggesting cochlear dysfunction. Our study strengthens the hypothesis that Vitiligo is a significant factor for the altered cochlear function, and that melanin may, in fact, have an important role in cell metabolism, facilitating substance exchanges and maintaining endolymph, perilymph and ionic balance [21].…”

Section: Discussionmentioning

confidence: 99%

Audiological and Electrophysiological Changes in Patients with Vitiligo

Arya

Munjal

Panda

et al. 2015

Indian J Otolaryngol Head Neck Surg

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The study was conducted to evaluate the audiological and electrophysiological findings in patients with Vitiligo and to compare the findings with otologically and audiologically normal controls. Study group included 50 subjects (25 Males, 25 Females) with Vitiligo (Mean age-27.4 years) and control group contained 40 age-matched normal hearing subjects. Pure tone audiometry (PTA) with extended high frequency audiometry, Otoacoustic emissions (OAEs), Tympanometry, Auditory brainstem responses (ABR) and Middle latency responses (MLR) were conducted in all subjects. Comparison of the study group with the control group showed statistically significant differences (p \ 0.05) on PTA, in Transient otoacoustic emissions (TOAEs) at 1, 2, 3, 4 kHz and in distortion product otoacoustic emissions (DPOAEs) at 357, 499, 704, 1003 Hz. On ABR, statistically significant differences were observed between the groups in wave I (p \ 0.01) in both ears, wave V (p \ 0.05) in left ear and on interpeak latency of I-III (p \ 0.01, p \ 0.05), III-V (p \ 0.01 in left ear) and I-V (p \ 0.01, p \ 0.05) in left and right ears respectively. When patients with localized vitiligo were compared with generalized vitiligo, the SNR of TOAEs was highly significant in both ears at 2 KHz (p \ 0.05), 3 kHz (p \ 0.01) and 4 kHz (p \ 0.05). PTA average of 2 KHz, 4 and 8 kHz (PTA2) showed a significant difference (p \ 0.01) when localized vitiligo was compared to generalized vitiligo. Results support possible auditory and electrophysiological changes in Vitiligo patients along with decreased cochlear function.

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Section: Discussionmentioning

confidence: 99%

Audiological and Electrophysiological Changes in Patients with Vitiligo

Arya

Munjal

Panda

et al. 2015

Indian J Otolaryngol Head Neck Surg

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“…[10][11][12] Studies also revealed that patients with vitiligo, who were asymptomatic for hearing loss and had normal hearing sensitivity, had subclinical cochlear pathology. [12][13][14] This subclinical cochlear dysfunction in patients with vitiligo was revealed by absent or abnormal OAEs.…”

Section: What's Already Known About This Topic?mentioning

confidence: 99%

“…It has been hypothesized that the loss of MCs and the subsequent decrease in melanin production, which occurs in vitiligo, could lead to cochlear dysfunction and subsequently to sensorineural hearing loss . Although some investigators could not find a significant association between vitiligo and sensorineural hearing loss, several clinical studies using conventional pure tone audiograms revealed that 12·5–18·9% of patients with vitiligo had sensorineural hearing loss . Studies also revealed that patients with vitiligo, who were asymptomatic for hearing loss and had normal hearing sensitivity, had subclinical cochlear pathology .…”

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confidence: 99%

Most individuals with either segmental or non-segmental vitiligo display evidence of bilateral cochlear dysfunction

et al. 2014

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“…Psychological interventions should be offered to help patients with vitiligo cope with their disease. Patients can have significant co-morbidities like autoimmune thyroid disease, and ophthalmological and auditory effects from the loss of pigment have been reported [16]. The clinical features and management of vitiligo have been reviewed recently [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Vitiligo, reactive oxygen species and T-cells

2010

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The acquired depigmenting disorder of vitiligo affects an estimated 1% of the world population and constitutes one of the commonest dermatoses. Although essentially asymptomatic, the psychosocial impact of vitiligo can be severe. The cause of vitiligo remains enigmatic, hampering efforts at successful therapy. The underlying pathogenesis of the pigment loss has, however, been clarified to some extent in recent years, offering the prospect of effective treatment, accurate prognosis and rational preventative strategies. Vitiligo occurs when functioning melanocytes disappear from the epidermis. A single dominant pathway is unlikely to account for all cases of melanocyte loss in vitiligo; rather, it is the result of complex interactions of biochemical, environmental and immunological events, in a permissive genetic milieu. ROS (reactive oxygen species) and H2O2 in excess can damage biological processes, and this situation has been documented in active vitiligo skin. Tyrosinase activity is impaired by excess H2O2 through oxidation of methionine residues in this key melanogenic enzyme. Mechanisms for repairing this oxidant damage are also damaged by H2O2, compounding the effect. Numerous proteins and peptides, in addition to tyrosinase, are similarly affected. It is possible that oxidant stress is the principal cause of vitiligo. However, there is also ample evidence of immunological phenomena in vitiligo, particularly in established chronic and progressive disease. Both innate and adaptive arms of the immune system are involved, with a dominant role for T-cells. Sensitized CD8+ T-cells are targeted to melanocyte differentiation antigens and destroy melanocytes either as the primary event in vitiligo or as a secondary promotive consequence. There is speculation on the interplay, if any, between ROS and the immune system in the pathogenesis of vitiligo. The present review focuses on the scientific evidence linking alterations in ROS and/or T-cells to vitiligo.

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A study on otoacoustic emissions and supression effects in patients with Vitiligo

Cited by 23 publications

References 15 publications

Audiological and Electrophysiological Changes in Patients with Vitiligo

Audiological and Electrophysiological Changes in Patients with Vitiligo

Most individuals with either segmental or non-segmental vitiligo display evidence of bilateral cochlear dysfunction

Vitiligo, reactive oxygen species and T-cells

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