Most individuals with either segmental or non-segmental vitiligo display evidence of bilateral cochlear dysfunction

Anbar, Tag S.; Elbadry, Mohamed; McGrath, John A.; Abdel-Azim, Eman S.

doi:10.1111/bjd.13276

Cited by 24 publications

(26 citation statements)

References 13 publications

(34 reference statements)

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“…This difference was not statistically significant, and the authors concluded that, contrary to observations in early onset vitiligo, late onset vitiligo did not seem to be associated with audiological abnormalities . Another study comparing the cochlear function of patients with NSV and SV demonstrated that bilateral cochlear dysfunction was common in both subtypes of the disease . A study by Gopal et al .…”

Section: Ocular and Audiological Abnormalities In Patients With Vitiligomentioning

confidence: 87%

“…The association between vitiligo and audiological abnormalities are highlighted in the literature . Melanocytes are also distributed in the membranous labyrinth of the inner ear with the heaviest pigmentation in scala vestibuli.…”

Section: Ocular and Audiological Abnormalities In Patients With Vitiligomentioning

confidence: 99%

“…Melanocytes are also distributed in the membranous labyrinth of the inner ear with the heaviest pigmentation in scala vestibuli. The role of these is not fully elucidated, but they are believed to be important for the development of endolymphatic potentials as well as for maintenance and normal function of stria vascularis . In a study by Akay et al ., in which audiometry was performed in 53 vitiligo patients and 50 age and gender matched controls, sensorineural hearing loss (SNHL) was observed in 37.7% of the cases and 16% of the controls.…”

Section: Ocular and Audiological Abnormalities In Patients With Vitiligomentioning

confidence: 99%

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Comorbidities in vitiligo: comprehensive review

2018

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Vitiligo is a common skin disorder characterized by idiopathic, progressive cutaneous hypomelanosis. Vitiligo is associated with several comorbid autoimmune, systemic, and dermatological diseases, primarily thyroid disease, alopecia areata, diabetes mellitus, pernicious anemia, systemic lupus erythematosus, rheumatoid arthritis, Addison's disease, inflammatory bowel disease, Sjögren's syndrome, dermatomyositis, scleroderma, ocular and audiological abnormalities, psoriasis, and atopic dermatitis. It is essential to increase awareness of these comorbidities in order to improve the disease burden and quality of life of patients with vitiligo. Herein, we review the association with the most frequent comorbidities associated with vitiligo.

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Section: Ocular and Audiological Abnormalities In Patients With Vitiligomentioning

confidence: 87%

Section: Ocular and Audiological Abnormalities In Patients With Vitiligomentioning

confidence: 99%

Section: Ocular and Audiological Abnormalities In Patients With Vitiligomentioning

confidence: 99%

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Comorbidities in vitiligo: comprehensive review

2018

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“…Progressive skin depigmentation in vitiligo is associated with the loss of melanocytes from the basal layer of the epidermis . Other organs can be affected, and patients sometimes incur visual or auditory impairment . Loss of hair pigmentation can follow depigmentation of the skin and rarely precedes it …”

Section: Introductionmentioning

confidence: 99%

The convergence theory for vitiligo: A reappraisal

Kundu

Mhlaba

Rangel

et al. 2018

Experimental Dermatology

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Vitiligo is characterized by progressive loss of skin pigmentation. The search for aetiologic factors has led to the biochemical, the neurologic and the autoimmune theory. The convergence theory was then proposed several years ago to incorporate existing theories of vitiligo development into a single overview of vitiligo aetiology. The viewpoint that vitiligo is not caused only by predisposing mutations, or only by melanocytes responding to chemical/radiation exposure, or only by hyperreactive T cells, but rather results from a combination of aetiologic factors that impact melanocyte viability, has certainly stood the test of time. New findings have since informed the description of progressive depigmentation. Understanding the relative importance of such aetiologic factors combined with a careful selection of the most targetable pathways will continue to drive the next phase in vitiligo research: the development of effective therapeutics. In that arena, it is likewise important to acknowledge that pathways affected in some patients may not be altered in others. Taken together, the convergence theory continues to provide a comprehensive viewpoint of vitiligo aetiology. The theory serves to intertwine aetiologic pathways and will help to define pathways amenable to disease intervention in individual patients.

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“…3 The aetiopathogenesis of NSV and SV has not been fully elucidated, and it is possible that the two subtypes share common mechanisms for initiation of the disease, but diverge in the progression phase, as depigmentation rapidly stabilizes in SV, but not NSV. 5 There is much data to support an autoimmune phase in the extension of vitiligo, and mechanical and chemical trauma are known environmental stressors that accelerate disease appearance. However, the events that initiate the loss of melanocytes are still a subject of debate.…”

mentioning

confidence: 99%