A Study on Assessment of Patients Health Related Quality of Life During Tuberculosis Treatment in a Tertiary Care Teaching Hospital

Abstract

Background: Tuberculosis is one of the leading causes of mortality and morbidity around the world, infecting approximately 8 billion people, with an annual death rate of close to 1 million. The present study was conducted to evaluate the impact of tuberculosis treatment on health related quality of life (HRQoL) of patients with active and inactive tuberculosis by evolving HRQoL questionnaire (SF-36v2). Methodology: A prospective follow-up study was conducted for total 70 patients (56 men and 14 women) diagnosed with tuberculosis (TB) in Navodaya Medical College Hospital & Research Centre, Raichur for a period of 6 months. The HRQoL of TB patients was assessed in three phases: at the onset of treatment, at one month (middle of intensive phase) and two months (end of intensive phase), after the initiation of anti-tuberculosis therapy. Results: A total of 70 patients completed the SF-36v2 questionnaire at the start of their treatment. Out of these, 53 and 41 completed the questionnaire at the second and third follow-ups, respectively. The mean physical component summary (PCS) scores at the start of the treatment, after one month and at the intensive phase were 42.09 ± 16.77, 53.89 ± 13.64 and 65.24 ± 12.86, respectively. Similarly, the mean mental component summary (MCS) scores at the start of the treatment, after one month and at the intensive phase were 43 ± 17.07, 52.19 ± 14.12 and 62.17 ± 15.12, respectively. Conclusion: The HRQoL improved with the treatment, the scores on component summary measures revealed the improvement of both physical and mental health among study patients at the end of intensive phase.

EQ-5D-3L-Derived Health-Related Quality of Life Among Tuberculosis Patients in Sri Lanka

“…It was evident from this study that TB affects the dimensions of mobility, self-care, usual activities, pain/discomfort and anxiety/depression of HRQOL in keeping with results of other studies in different countries that assessed HRQOL of TB patients using different instruments [14][15][16][17]33]. It was also evident that HRQOL of TB patients has been improved significantly with standard anti-TB medication for 6 months which is also consistent with similar studies done in North India among new PTB patients using WHOQOL-BREF [8], another study done in India among PTB patients using SF-36 [21], in Indonesia among smear-positive PTB patients using SGRQ [22] and in Pakistan among new PTB patients using EQ-5D-3L [17]. The only study reported from Sri Lanka [16] also shows similar results of significant improvement of the HRQOL (p < 0.001) among TB patients during the medication period, as measured by the WHOQOL-BREF.…”

“…Results show that HRQOL was very low at the initiation of treatment and improved significantly at the completion of treatment [15,20]. Different tools such as World Health Organization Quality of Life BREF (WHOQOL-BREF) [8], Short-Form 36 (SF-36) [21] and St. George's Respiratory Questionnaire (SGRQ) [22] have been used to measure HRQOL. The authors have concluded that HRQOL indicators are important as patient-reported health outcomes of TB patients with other clinical and laboratory indicators to assess the complete health status of patients [8,21,[23][24][25].…”

“…Different tools such as World Health Organization Quality of Life BREF (WHOQOL-BREF) [8], Short-Form 36 (SF-36) [21] and St. George's Respiratory Questionnaire (SGRQ) [22] have been used to measure HRQOL. The authors have concluded that HRQOL indicators are important as patient-reported health outcomes of TB patients with other clinical and laboratory indicators to assess the complete health status of patients [8,21,[23][24][25]. Most studies have described the HRQOL separately in psychological, social, functional and physical dimensions of the HRQOL construct [24,26,27].…”

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“…Remaining cases were either with one (or) more co-morbid conditions. Institutional patient's mortality and morbidity due to certain endemicity among the inpatient population is currently essential to reduce the impact of clinical consequences 9 .…”

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“…In addition, just the diagnosis of TB alone may lead to depression and anxiety or contribute to the worsening and persistence of disease symptoms, which follows with fear, frustration, and disappointment 9 . Furthermore, most TB patients have no knowledge of disease progress and treatment which can cause more anxiety and feelings of frustration and decreases the QOL among the patients 10 .…”