A Study on Alter Ation of Serum Lipid Profile in Gestational Proteinuric Hypertension

Abstract

BACKGROUND: Changes in lipid metabolism occurs in normal pregnancy during third trimester. This dyslipidemia indicative of insulin resistance is accentuated with Pre-eclampsia and Eclampsia. It contributes to both the pathogenesis of pre-eclampsia and to the risk of later-life cardiovascular disease in these patients. I have attempted to study the alterations in lipid profile in normal pregnancy, pre-eclampsia and eclampsia. MATERIALS AND METHODS: This study was conducted in Govt. Medical College for a period of 6 months. 25 normotensive non-pregnant women, 25 normal pregnant women, 25 pre eclampsia patients and 25 eclampsia patients were selected All the antenatal were in third trimester. Serum lipid profile was determined. Data analysis was done by excel sheet and SPSS software. RESULTS: Serum Triglycerides, VLDL, Total Cholesterol, LDL Cholesterol and HDL Cholesterol were significantly elevated in last trimester of normal pregnancy when compared to normal non-pregnant women. Also a significant increase in serum triglycerides and VLDL were seen in pre-eclampsia when compared to that of normal pregnancy. Also a significant decrease in HDL Cholesterol levels were seen in eclampsia when compared to normal pregnancy. CONCLUSION: Dyslipidemia suggestive of an exaggerated insulin resistance was found in pre eclampsia and eclampsia. Early interventions like prevention of obesity, exercise and balanced diet can reduce the risk of future cardiovascular morbidity and mortality in these patients.

Excess weight and dyslipidemia and their complications during pregnancy: a systematic review

“…A more recent study has compared pregnant and non-pregnant women, both of normal weight, and noted a significantly higher result for means of TG, TC, VLDL, LDLc in normal-weight pregnant women and concomitant reduction in HDLc. 14 Other studies have identified a gradual increase in lipid patterns of TG, CT, VLDL and HDLc, after the 12 th week of pregnancy, especially in the second and third trimesters, in response to estrogen stimulation and resistance to insulin and pointed to the increased TG during gestation, which suggests a correlation with the risk of pre-eclampsia and preterm birth. 15,16 It can be deduced that, for pregnant women of adequate weight, the increase or decrease in HDLc parameters will diverge in some scientific studies.…”

“…7,26 Studies with animals may also aid scientific progress on the alterations caused by obesity. 13,14 Mertens et al 27 studied obese insulin-resistant animals with severe dyslipidemia and found a deficiency of leptin and LDL receptors in the metabolism of the animal and an increase in oxidative stress.…”