A study on adverse drug reactions to first-line antiretroviral therapy in HIV infected patients at a tertiary care hospital in Northeast India

Jain, Ankur; Lihite, Ratan J.; Lahkar, Mangala; Baruah, Swaroop Kumar

doi:10.1016/j.hivar.2016.10.001

Cited by 5 publications

(5 citation statements)

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“…These side effects were probably due to efavirenz [14] and occurred in seven patients receiving lamivudine, tenofovir, and efavirenz. Our findings are supported by the research of Jain et al in India [15]. They showed that the most commonly used therapeutic combination was lamivudine, tenofovir, and efavirenz (83 of 100 patients), but that 81 experienced side effects due to efavirenz [15].…”

Section: Side Effectssupporting

confidence: 89%

“…Our findings are supported by the research of Jain et al in India [15]. They showed that the most commonly used therapeutic combination was lamivudine, tenofovir, and efavirenz (83 of 100 patients), but that 81 experienced side effects due to efavirenz [15]. Although the side effects of efavirenz commonly disappeared after 6-10 weeks, they could persist long-term in some patients [16].…”

Section: Side Effectssupporting

confidence: 88%

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Monitoring Side Effects of Antiretroviral Therapy in Patients With Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome

2018

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Objective: This study aimed to monitor the side effects of patients who received antiretroviral medications in a subdistrict of West Jakarta in 2017.Methods: Descriptive research was performed using data collected prospectively from patients who met our inclusion criteria (total sampling).Primary data were obtained from interviews, and secondary data were obtained from medical and prescription records. The Naranjo algorithm wasused to classify side effects.Results: The side effects experienced by patients in this study fell into probable (45.45%) and possible (36.36%) categories. However, age (p=0.379),gender (p=1), and length of treatment (p=0.07) did not significantly affect the occurrence of side effects.Conclusion: Monitoring the side effects of antiretroviral medicine is necessary to prevent serious and rare side effects. The occurrence of side effects,whether they have an established causal relationship or not, could be prevented by appropriate monitoring.

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Section: Side Effectssupporting

confidence: 89%

Section: Side Effectssupporting

confidence: 88%

Monitoring Side Effects of Antiretroviral Therapy in Patients With Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome

2018

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“…Highly active antiretroviral therapy (HAART) has evolved over the years since the discovery of antiretroviral drugs in 1985 (Mitsuya et al ., ), leading to a boost in the quality of life in people living with HIV and AIDS (PLWHA). The increased life span has however been paralleled with several comorbidities (Nagiah et al ., ) including nervous disorders (Jain et al ., ), diabetes mellitus (Karamchand et al ., ), malignancies (Ledru et al ., ), sexual dysfunctions (Lamba et al ., ) as well as impaired fertility (Azu et al ., ).…”

Section: Introductionmentioning

confidence: 99%

Naringenin attenuates highly active antiretroviral therapy‐induced spermDNAfragmentations and testicular toxicity in Sprague‐Dawley rats

et al. 2017

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SUMMARYHighly active antiretroviral therapy has evolved over the years, leading to a boost in the quality of life in people living with HIV and AIDS. However, growing evidence has shown that highly active antiretroviral therapy has deleterious effects on the testes and the overall reproductive capacity. Therefore, this study is to determine the adjuvant potential of Naringenin on highly active antiretroviral therapy-induced perturbations in fertility of male Sprague-Dawley rats. Thirty adult male Sprague-Dawley rats were divided into six groups viz -Control; H: 30 mg/kg of highly active antiretroviral therapy (EFV, 600 mg + FTC, 200 mg + TDF, 300 mg); N40: Naringenin, 40 mg/kg; N80: Naringenin, 80 mg/kg; HN40: highly active antiretroviral therapy + Naringenin, 40 mg/kg; HN80: highly active antiretroviral therapy + Naringenin, 80 mg/kg. The rats were euthanized after 4 weeks. Results showed that there was a significant decrease in sperm count (p < 0.001), spermatozoa with normal morphology (p < 0.001) and progressive sperm motility (p < 0.05) of H compared to the control and the HN groups. Likewise, fragmentations increased (p < 0.05) in tail lengths of sperm DNA in H compared to control. HN40 and HN80 decreased tail lengths compared to H (p < 0.001). There was also a decrease in %tail DNA and tail moment in HN40 (p < 0.001) compared to H. Luteinizing hormone significantly increased (p < 0.05) in HN40, HN80, and N40 (p < 0.001) but decreased in H (p < 0.05) compared to control. The diameter of the seminiferous tubules also decreased (p < 0.05) in H compared to control, N80, and HN40. Likewise, the area of the seminiferous tubules in group H decreased (p < 0.05) compared to N80 and HN80. The seminiferous tubules epithelium increased (p < 0.05) in N40 and HN40 compared to H. This study establishes that highly active antiretroviral therapy has deleterious effects on the testicular microanatomy, sperm parameters, and sperm DNA of Sprague-Dawley rats, which may impair fertility but Naringenin is a potential complimentary adjuvant.

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“…In this study gastritis (9.6%) was reported by HIV patients. Similarly, a study in India reported that gastritis (13.13%) was among the major adverse effects [30]. A study in Ethiopia, HFSH, reported that the major adverse effect was lipodystrophy (49.2%) (18), but in this study only 3 (0.8%) study participants were reported.…”

Section: Discussionmentioning

confidence: 62%

Coping Strategies for Adverse Effects of Antiretroviral Therapy among Adult HIV Patients Attending University of Gondar Referral Hospital, Gondar, Northwest Ethiopia: A Cross-Sectional Study

Gelaw

Adugna

Tsegaye

et al. 2018

AIDS Research and Treatment

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Background Adverse effects from antiretroviral therapy (ART) have an impact on quality of life and medication adherence. There is no clear understanding of how people manage the adverse effects of ART. The individual taking medications which cause serious adverse effects may choose to stop or reduce the medications to relieve the adverse effects. Hence, this study was aimed at assessing coping strategies for adverse effects of ART among adult human immunodeficiency virus (HIV) patients. Methods A cross-sectional study was conducted at HIV clinic of University of Gondar Referral Hospital (UoGRH). A total of 394 study participants were recruited by systematic random sampling. Data were collected through interviewing patients. Data were entered to Epi-Info 3.5.4 and analyzed using SPSS-20.0. Descriptive statistics were used to summarize patient's sociodemographic data and the adverse effects of their ART regimen. Binary and multivariate logistic regressions were used to investigate the potential predictors of nonadherence coping strategies. Results The majorities of study participants were females (66%) and aged between 35 and 44 years (38.1%). The major adverse effects reported by the participants were headache (48.2%) followed by fatigability (18%) and loss of appetite (17.5%). Coping strategies used by HIV patients for adverse effect of ART were positive emotion coping strategy (91.1%), social support seeking (76.6%), taking other medications (76.6%), information seeking (48.7%), and nonadherence (35.5%). Younger age (AOR = 29.54, 95% CI = 2.49–35.25, p = 0.007), low level of education (AOR = 5.70, 95% CI = 2.16-15.05, p < 0.001), and living far from the health institution (AOR = 2.68, 95% CI = 1.29–5.57, p = 0.008) were associated with nonadherence coping strategy to relieve the adverse effects of ART. Conclusion The present study revealed that positive emotion coping was the most commonly used strategy. Age, level of education, and distance from health institution were the predictors of nonadherence coping strategy.

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A study on adverse drug reactions to first-line antiretroviral therapy in HIV infected patients at a tertiary care hospital in Northeast India

Cited by 5 publications

References 14 publications

Monitoring Side Effects of Antiretroviral Therapy in Patients With Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome

Monitoring Side Effects of Antiretroviral Therapy in Patients With Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome

Naringenin attenuates highly active antiretroviral therapy‐induced spermDNAfragmentations and testicular toxicity in Sprague‐Dawley rats

Coping Strategies for Adverse Effects of Antiretroviral Therapy among Adult HIV Patients Attending University of Gondar Referral Hospital, Gondar, Northwest Ethiopia: A Cross-Sectional Study

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