A Study of Two Unusual Blood-group Antigens in West Africans

Chalmers, J. N. M.; Ikin, Elizabeth W.; Mourant, A. E.

doi:10.1136/bmj.2.4829.175

Cited by 35 publications

(15 citation statements)

References 2 publications

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“…That the Sheerin serum does not contain anti-Hu is clear from the finding of 12 Hu+, Tm-bloods. Wiener [16] and Chalmers et al [2] reported an incidence of 7% Hu+ in American Negroes and our finding of 7.2% is in excellent agreement. The Hu antigen is reported as being present but rare in Caucasians by these workers.…”

Section: Discussionsupporting

confidence: 80%

“…Our finding of four (0.8%) He+ in the Cau casian series tested is, as far as we are aware, the first reported in stance of He antigen in Caucasians. Chalmers et al [2] found none in testing 1500 Europeans so that our finding the antigen in the New York Caucasian series suggests the possibility of gene flow. Henshaw has previously been reported [10,8,18] as being found predominantly with a single MN gene different for each population studied, but Shapiro [14] found He to be produced by a variety of MN genes in Bantus as we have done in this New York Negro sample.…”

Section: Discussionmentioning

confidence: 82%

“…Of 1000 bloods typed 41 were found to be Hu+. It is known from the work of Wiener [16] and Chalmers et al [2] that the majority of Hu + bloods are of type N or MN so that by using the frequency of Tm in these two types it can be calculated that of the 41 Hu+ samples, 14 would be expected to be Tm+ as well. In fact 29 of the 41 are Tm+, strongly suggesting that the gene that produces Hu more often than not produces Tm as well.…”

Section: Discussionmentioning

confidence: 99%

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Sj, a New Antigen in the MN System, and Further Studies on Tm

Issitt¹,

Haber²,

Allen³

1968

Vox Sanguinis

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A serum containing antibody activity within the MN blood group system is described. Absorption studies showed that the serum detects two new antigenic determinants that have been named Tm and Sj. The results obtained when 1,400 bloods, 500 from Negroes and 900 from Caucasians, were tested for ten antigens in the MN system - M, M(1), N, S, s, U, Hu, He, Tm and Sj - are presented. Unlike most of the recently described new antigens in the MN system both Tm and Sj are of fairly high frequency in Caucasians and Negroes. Calculations of gene frequencies from these data are published in an accompanying paper [7].

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

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Sj, a New Antigen in the MN System, and Further Studies on Tm

Issitt¹,

Haber²,

Allen³

1968

Vox Sanguinis

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“…This typically Negro antigen is closely (Chalmers et al 1953;Ikin and Mourant 1951;Junqueira and Wishart 1956), if not absolutely, linked with the MNSs genes (Nijenhuis 1953;Shapiro 1956;Zoutendyk 1955). It appears that the gene responsible for the Henshaw (He) phenotype is rare, if present a t all, among the 166 Maya Indians tested.…”

Section: Mnss Systemmentioning

confidence: 99%

Distribution of Hereditary Blood Antigens among American Indians in Middle America: Lacandón and Other Maya

Matson

Swanson

1961

American Anthropologist

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“…Human and rabbit polyclonal anti-He reagents detect the antigen on erythrocytes from 2-3% of blacks [7,8]. The production of murine monoclonal anti-He has made it possible to study the He antigen in more detail.…”

Section: Introductionmentioning

confidence: 99%

Expression of the Erythrocyte Antigen Henshaw (He; MNS6): Serological and Immunochemical Studies

Reid¹,

Lomas-Francis²,

Daniels³

et al. 1995

Vox Sanguinis

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Production of murine monoclonal antibodies to the low prevalence MNS antigen Henshaw (He; MNS6) has enabled more detailed study of this antigen. Using these directly hemagglutinating anti-He, red blood cells (RBCs) from 1695 people of African origin were screened in the USA and England. The prevalence of He+ samples among these donors was 2.1%. In Natal, blood samples from 1218 black donors were screened with rabbit anti-He. The prevalence of He+ donors in this population was 7.0%. Immunoblotting confirmed that the He antigen is carried on an erythrocyte membrane component with a molecular mass that is indistinguishable from glycophorin B. Hemagglutination and immunoblotting demonstrated that ten of 56 He+ samples tested more extensively had a reduced expression of the He antigen. The majority of He+ RBCs were S+; those He+ RBC samples that were S-s+ more frequently had a weakened expression of He.

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A Study of Two Unusual Blood-group Antigens in West Africans

Cited by 35 publications

References 2 publications

Sj, a New Antigen in the MN System, and Further Studies on Tm

Sj, a New Antigen in the MN System, and Further Studies on Tm

Distribution of Hereditary Blood Antigens among American Indians in Middle America: Lacandón and Other Maya

Expression of the Erythrocyte Antigen Henshaw (He; MNS6): Serological and Immunochemical Studies

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