A study of the value of trabecular bone score in fracture risk assessment of postmenopausal women

Mirzaei, Alireza; Jahed, Seyed Adel; Nojomi, Marzieh; Rajaei, Alireza; Zabihiyeganeh, Mozhdeh

doi:10.1016/j.tjog.2018.04.011

Cited by 19 publications

(19 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ripamonti et al [36] reported that TBS was not associated with spine fragility fractures in postmenopausal women with osteoporosis, although TBS-but not spine BMD-was a significant risk factor for spine fragility fractures in postmenopausal women without osteoporosis. In addition, Mirzaei et al [37] compared the predictive value of three different models using BMD, TBS, and the combination of BMD and TBS for spine fragility fractures in postmenopausal women, and they showed no clinical benefit of TBS in postmenopausal women. Adding TBS to BMD or FRAX neither improved the predictive value of BMD for vertebral fractures nor changed the treatment decisions made based on FRAX [37].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, Mirzaei et al [37] compared the predictive value of three different models using BMD, TBS, and the combination of BMD and TBS for spine fragility fractures in postmenopausal women, and they showed no clinical benefit of TBS in postmenopausal women. Adding TBS to BMD or FRAX neither improved the predictive value of BMD for vertebral fractures nor changed the treatment decisions made based on FRAX [37]. In this study, no additional benefit of TBS adjustment was found for the predictive power of the FRAX with BMD model for MOFs and hip fractures.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Low Predictive Value of FRAX Adjusted by Trabecular Bone Score for Osteoporotic Fractures in Korean Women: A Community-Based Cohort Study

Kim¹,

Kim²,

Kim³

et al. 2020

Endocrinol Metab

View full text Add to dashboard Cite

Background: The value of the Fracture Risk Assessment Tool (FRAX) and the trabecular bone score (TBS) for assessing osteoporotic fracture risk has not been fully elucidated in Koreans. We conducted this study to clarify the predictive value of FRAX adjusted by TBS for osteoporotic fractures in Korean women. Methods: After screening 7,192 eligible subjects from the Ansung cohort, 1,165 women aged 45 to 76 years with available bone mineral density (BMD) and TBS data were enrolled in this study. We assessed their clinical risk factors for osteoporotic fractures and evaluated the predictive value of FRAX with or without BMD and TBS. Results: During the mean follow-up period of 7.5 years, 99 (8.5%) women suffered major osteoporotic fractures (MOFs) and 28 (2.4%) experienced hip fractures. FRAX without BMD, BMD-adjusted FRAX, and TBS-adjusted FRAX were significantly associated with the risk of MOFs (hazard ratio [HR] per percent increase, 1.08; 95% confidence interval [CI], 1.03 to 1.14; HR, 1.09; 95% CI, 1.03 to 1.15; and HR, 1.07; 95% CI, 1.02 to 1.13, respectively). However, BMD-adjusted FRAX and TBS-adjusted FRAX did not predict MOFs better than FRAX without BMD based on the Harrell's C statistic. FRAX probabilities showed limited value for predicting hip fractures. The cutoff values of FRAX without BMD, FRAX with BMD, and FRAX with BMD adjusted by TBS for predicting MOFs were 7.2%, 5.0%, and 6.7%, respectively. Conclusion: FRAX with BMD and TBS adjustment did not show better predictive value for osteoporotic fractures in this study than FRAX without adjustment. Moreover, the cutoff values of FRAX probabilities for treatment might be lower in Korean women than in other countries.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Low Predictive Value of FRAX Adjusted by Trabecular Bone Score for Osteoporotic Fractures in Korean Women: A Community-Based Cohort Study

Kim¹,

Kim²,

Kim³

et al. 2020

Endocrinol Metab

View full text Add to dashboard Cite

show abstract

“…TBS contains structural information that are not captured by BMD measurements [457,458]. TBS can be used, though not very accurately, to assess fracture risk independently of BMD and CRFs [453,459]. TBS has been used in conjunction with BMD alone and with BMD and CRFs in available fracture risk assessment tools such as FRAX, to improve the accuracy of bone fracture predictions [458].…”

Section: Single-variable Risk Analysismentioning

confidence: 99%

“…TBS has been used in conjunction with BMD alone and with BMD and CRFs in available fracture risk assessment tools such as FRAX, to improve the accuracy of bone fracture predictions [458]. In the study performed by [459], however, TBS did not improve BMD and FRAX fracture predictions. TBS depends on HU variations obtained in vivo, which can have many causes [457] and is most commonly estimated using DXA.…”

Section: Single-variable Risk Analysismentioning

confidence: 99%

See 1 more Smart Citation

Patient-Specific Bone Multiscale Modelling, Fracture Simulation and Risk Analysis—A Survey

et al. 2019

View full text Add to dashboard Cite

This paper provides a starting point for researchers and practitioners from biology, medicine, physics and engineering who can benefit from an up-to-date literature survey on patient-specific bone fracture modelling, simulation and risk analysis. This survey hints at a framework for devising realistic patient-specific bone fracture simulations. This paper has 18 sections: Section 1 presents the main interested parties; Section 2 explains the organzation of the text; Section 3 motivates further work on patient-specific bone fracture simulation; Section 4 motivates this survey; Section 5 concerns the collection of bibliographical references; Section 6 motivates the physico-mathematical approach to bone fracture; Section 7 presents the modelling of bone as a continuum; Section 8 categorizes the surveyed literature into a continuum mechanics framework; Section 9 concerns the computational modelling of bone geometry; Section 10 concerns the estimation of bone mechanical properties; Section 11 concerns the selection of boundary conditions representative of bone trauma; Section 12 concerns bone fracture simulation; Section 13 presents the multiscale structure of bone; Section 14 concerns the multiscale mathematical modelling of bone; Section 15 concerns the experimental validation of bone fracture simulations; Section 16 concerns bone fracture risk assessment. Lastly, glossaries for symbols, acronyms, and physico-mathematical terms are provided.

show abstract

Do proximal hip geometry, trabecular microarchitecture, and prevalent vertebral fractures differ in postmenopausal women with type 2 diabetes mellitus? A cross-sectional study from a teaching hospital in southern India

et al. 2021

View full text Add to dashboard Cite

A study of the value of trabecular bone score in fracture risk assessment of postmenopausal women

Cited by 19 publications

References 22 publications

Low Predictive Value of FRAX Adjusted by Trabecular Bone Score for Osteoporotic Fractures in Korean Women: A Community-Based Cohort Study

Low Predictive Value of FRAX Adjusted by Trabecular Bone Score for Osteoporotic Fractures in Korean Women: A Community-Based Cohort Study

Patient-Specific Bone Multiscale Modelling, Fracture Simulation and Risk Analysis—A Survey

Do proximal hip geometry, trabecular microarchitecture, and prevalent vertebral fractures differ in postmenopausal women with type 2 diabetes mellitus? A cross-sectional study from a teaching hospital in southern India

Contact Info

Product

Resources

About