A Study of the Synthesis and Deposition of Lipids in Brain and Other Tissues With Deuterium as an Indicator

Waelsch, Heinrich; Sperry, Warren M.; Stoyanoff, V.A.

doi:10.1016/s0021-9258(18)73186-4

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Cholesterol Synthesis In the Brain1

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2011

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Cited by 78 publications

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“…First evidence that brain cells synthesize cholesterol has been published 60 years ago by the group of Heinrich Waelsch. Their pioneering use of heavy water to study lipid synthesis in rats indicated that cholesterol is synthesized in the brain and that the rate of synthesis is higher during early postnatal development than in adult animals [55,56]. Using similar methods and thorough quantification, Quan and colleagues revealed that cholesterol synthesis in the developing mouse brain peaks during the second postnatal week and varies across regions.…”

Section: Cholesterol Synthesis In the Brainmentioning

confidence: 99%