A study of the relationship of reticuloendotheliosis virus to the avion leukosis-sarcoma complex of viruses

Halpern, Melissa D.; Wade, Eugene; Rucker, Ellis; Baxter-Gabbard, K. L.; Levine, Alvin S.; Friis, Robert R.

doi:10.1016/0042-6822(73)90206-7

Cited by 63 publications

(49 citation statements)

References 29 publications

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“…In all cases, ['4C]amino acidlabeled B77 or PR RSV-C viral protein was coelectrophoresed to serve as a marker in the gel. The preparation of labeled viral protein and the method for slicing and counting gels has been described (13 (Fig. 2) indicates that they are not fucosylated.…”

Section: Methodsmentioning

confidence: 99%

Isolation of the Major Viral Glycoprotein and a Putative Precursor from Cells Transformed by Avian Sarcoma Viruses

Halpern¹,

Bolognesi²,

Lewandowski³

1974

Proc. Natl. Acad. Sci. U.S.A.

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Immune precipitation with a monospecific antiserum was employed to study the synthesis of the major viral glycoprotein gp85. Labeled gp85 was detectable by polyacrylamide gel electrophoresis of immune precipitates prepared from lysates of transformed cells which had been labeled for long term with radioactive amino acid or fucose. When immune precipitates were prepared from lysates of cells pulse-labeled with radioactive amino acid, the bulk of the precipitated counts did not appear in gp85 but in a heterogeneous protein fraction with a mean molecular weight of approximately 70,000; this fraction has been designated p70. If, however, the pulse label was followed by incubation of the cells in medium containing excess unlabeled amino acid, the bulk of the precipitated counts comigrated with gp85. Similar pulse-labeling experiments with radioactive fucose and glucosamine suggested that p70 represents incompletely glycosylated precursor to gp85.

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Section: Methodsmentioning

confidence: 99%

Isolation of the Major Viral Glycoprotein and a Putative Precursor from Cells Transformed by Avian Sarcoma Viruses

Halpern¹,

Bolognesi²,

Lewandowski³

1974

Proc. Natl. Acad. Sci. U.S.A.

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“…Defects in the interferon pathway may account for an increased susceptibility to virus infection (42). Alternatively, immunological processes induced by virus infection are responsible for the cytotoxicity observed (24,33). Although oncolytic viruses represent a promising possibility for effective therapeutic strategies against resistant cancers, only limited investigations to explain the cellular mechanisms of these oncolytic effects have been conducted so far.…”

mentioning

confidence: 99%

p53-Independent Endoplasmic Reticulum Stress-Mediated Cytotoxicity of a Newcastle Disease Virus Strain in Tumor Cell Lines

Fábián

Csatary

Szeberényi

et al. 2007

J Virol

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“…Despite these differences, PV appears to be distantly related to ALSV, since the glycoproteins of the former virus can be effectively utilized by RSV deficient in the synthesis of the glycoproteins. REV was shown to be incapable of acting as a helper for the defective RSV (20). Further, in this study cultures fully infected with TDSNV did not produce any interference with B-RSV(RAV-2), B-RSV(GPV-ny), or B-RSV(APV), indicating a difference between the envelope glycoproteins of TDSNV and PV.…”

Section: Isolation Ofmentioning

confidence: 73%

“…REV is known to be similar to avian leukosis virus in its structure and life cycle, but their protein compositions are different. The electropherograms of TDSNV proteins were essentially the same as those described by Halpern et al (20) and Mosser et al (21). Again none of the proteins had the same mobility as those of APV.…”

Section: Isolation Ofmentioning

confidence: 75%

“…(9). The present study clearly shows that structural proteins of both GPV and APV are substantially different in composition from any of those of ALSV (15,22), mammalian oncornaviruses (23), REV (20,21), visna virus (24,25), rhabdovirus (26), myxovirus (27,28), or paramyxovirus (29). The PV proteins were also shown to be immunologically unrelated to three major ALSV proteins.…”

Section: Isolation Ofmentioning

confidence: 87%

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Pheasant virus: new class of ribodeoxyvirus.

Hanafusa¹,

Hanafusa²,

Metroka³

et al. 1976

Proc. Natl. Acad. Sci. U.S.A.

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(6) has been shown to contain nucleic acid sequences of both the endogenous virus genes and the exogenously infecting viruses (7). Likewise, endogenous viral genes were shown to exist in ring-necked pheasant and golden pheasant cells, and the new viruses isolated from these cells were called RAV-61 and golden pheasant virus (GPV) respectively (8, 9). The main criteria for the recovery of new viral genetic information in these isolates were the properties of viruses specified by the viral envelope, such as host range, sensitivity to interference, and antigenicity, which are the basis for the subgroup classification of ALSV.In the previous studies, we found no clear correlation between the expression of group specific antigens of ALSV in pheasant embryo cultures and the ease with which RAV-61 was recovered from the particular cultures (8). Further studies on the correlation of these two phenomena in other pheasant cells led us to the discovery that the GPV and another similar isolate from Amherst pheasants are different from the members of known ALSV in their structural pro-

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A study of the relationship of reticuloendotheliosis virus to the avion leukosis-sarcoma complex of viruses

Cited by 63 publications

References 29 publications

Isolation of the Major Viral Glycoprotein and a Putative Precursor from Cells Transformed by Avian Sarcoma Viruses

Isolation of the Major Viral Glycoprotein and a Putative Precursor from Cells Transformed by Avian Sarcoma Viruses

p53-Independent Endoplasmic Reticulum Stress-Mediated Cytotoxicity of a Newcastle Disease Virus Strain in Tumor Cell Lines

Pheasant virus: new class of ribodeoxyvirus.

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