A study of the relationship between serum lithium and plasma cortisol levels in manic depressive patients [letter]

Eroğlu, L; Atamer-Şimşek, Ş.; Yazıcı, Olcay; Keyer‐Uysal, Meral; Yuksel, Sinemis

doi:10.1111/j.1365-2125.1979.tb05917.x

Cited by 14 publications

(2 citation statements)

References 7 publications

(5 reference statements)

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“…Other studies have identified an increase in cortisol from baseline after a 12-day period of withdrawal from psychotropic treatment (Naber et al 1985;Albus et al 1985). Unlike antipsychotics, mood stabilisers, including lithium carbonate, have been shown to increase cortisol levels in a dose dependent manner (Platman and Fieve 1968;Bschor et al 2011;Eroglu et al 1979).…”

Section: Levels Of Cortisol In Schizophrenia and Bipolar Disordermentioning

confidence: 96%

Stress, Schizophrenia and Bipolar Disorder

Green

Girshkin

Teroganova

et al. 2014

Behavioral Neurobiology of Stress-Related Disorders

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The role of stress in precipitating psychotic episodes in schizophrenia and bipolar disorder has long been acknowledged. However, the neurobiological mechanism/s of this association have remained elusive. Current neurodevelopmental models of psychosis implicate early dysfunction in biological systems regulating hypothalamic-pituitary-adrenal axis and immune function, with long-term effects on the development of the brain networks responsible for higher order cognitive processes and stress reactivity in later life. There is also increasing evidence of childhood trauma in psychosis, and its impact on the development of brain systems regulating stress. These findings are emerging in the context of a new era of epigenetic methods facilitating the study of environmental effects on gene expression. The evidence is thus converging: exposure to stress at critical periods in life may be an important factor in the development of the brain dysfunction that represents psychosis vulnerability, rather than merely interacting with an independent 'biological vulnerability' to manifest in psychosis.

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Section: Levels Of Cortisol In Schizophrenia and Bipolar Disordermentioning

confidence: 96%

Stress, Schizophrenia and Bipolar Disorder

Green

Girshkin

Teroganova

et al. 2014

Behavioral Neurobiology of Stress-Related Disorders

View full text Add to dashboard Cite

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“…Medications usually used to treat mood episodes are known to alter glucocorticoids levels (Eroğlu et al, 1979; Gattaz et al, 1985; Meltzer et al, 1984; Pepin et al, 1989; Watson et al, 2007; Zobel et al, 2001). Treatment-free BD subjects in mania (not first episode) had elevated cerebrospinal fluid (CSF) and urinary free cortisol excretion compared with healthy subjects.…”

Section: Introductionmentioning

confidence: 99%

Plasma cortisol in first episode drug-naïve mania: Differential levels in euphoric versus irritable mood

Valiengo

Soeiro-de-Souza

Marques

et al. 2012

Journal of Affective Disorders

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Background Dysregulation of HPA axis has been widely described in subjects with bipolar disorder (BD), including changes in cortisol levels during mood episodes and euthymia. However, most of the studies were done with medicated BD patients with variable length of illness, which was shown to interfere on peripheral cortisol levels. Therefore, the present study aims to evaluate plasma cortisol levels in drug-naïve BD subjects during the first manic episode, as well as investigate the relationship between plasma cortisol levels and manic symptomatology. Methods Twenty-six drug-naïve patients were enrolled meeting criteria for a first manic episode in bipolar I disorder. Severity of mania was assessed using the Young Mania Rating Scale (YMRS). The control group included 27 healthy subjects matched by age and gender. Cortisol was quantified using a direct radioimmunoassay. Results Plasma cortisol levels were decreased during first manic episode compared to healthy controls. Higher cortisol levels were positively associated with the presence of irritability (dysphoria), while elated mania showed lower cortisol levels compared to controls. Limitation Data including larger samples are lacking. Conclusion Higher cortisol in dysphoric mania compared to predominantly elated/euphoric mania may indicate a clinical and neurobiological polymorphic phenomenon, potentially involving a higher biological sensitivity to stress in the presence of irritable mood. The present findings highlight the importance to add a dimensional approach to the traditional categorical diagnosis for future neurobiological studies in BD.

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