A study of the organic material of hen's-egg shell

Baker, J R; Balch, D. A.

doi:10.1042/bj0820352

Cited by 172 publications

(74 citation statements)

References 37 publications

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“…However, eggshell membranes have also been shown to contain other bioactive components, namely glycosaminoglycans (i.e. dermatan sulfate, chondroitin sulfate and hyaluronic acid and keratan sulfate) [9][10][11]. A number of these constituents have been shown previously to be beneficial in the treatment of OA [12,13].…”

Section: Introductionmentioning

confidence: 99%

NEM Brand Eggshell Membrane Effective in the Treatment of Pain Associated with Knee and Hip Osteoarthritis: Results from a Six Center, Open Label German Clinical Study

Danesch¹

2014

J Arthritis

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Objective: NEM ® brand eggshell membrane is a novel dietary supplement ingredient that contains naturally occurring glycosaminoglycans and proteins essential for maintaining healthy joints. A six center, open label clinical study was conducted to evaluate the efficacy and safety of NEM ® as a treatment for pain and inflexibility associated with osteoarthritis of the knee and/or hip in a European population.Methods: Forty-four subjects received oral NEM ® 500 mg once daily for eight weeks. The primary outcome measure was to evaluate the mean effectiveness of NEM ® in relieving general pain associated with moderate osteoarthritis of the knee and/or hip at 10,30 and 60 days utilizing a 10-question abbreviated questionnaire based on the WOMAC osteoarthritis questionnaire. Results: Supplementation with NEM® produced a significant treatment response from baseline at 10 days (Q1-6 and Q9) (8.6% to 18.1% improvement) and at 30 and 60 days for all nine pain-related questions evaluated (22.4% to 35.6% improvement) and at 30 and 60 days for stiffness (Q10)(27.4% to 29.3% improvement). In a Patient's Global Assessment, greater than 59% of patients rated the efficacy of NEM ® as good or very good following 60 days of supplementation. Physicians also rated the treatment effective in subjects, with greater than 75% having moderate or significant improvement from baseline after 60 days. There were no serious adverse events reported during the study and the treatment was reported to be well tolerated. Conclusions: Supplementation with NEM® significantly reduced pain, both rapidly (10 days) and continuously (60 days) demonstrating that it is a safe and effective therapeutic option for the treatment of pain associated with osteoarthritis of the knee and/or hip. Results from previous clinical studies on NEM ® can likely be extended to the broader European population.

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Section: Introductionmentioning

confidence: 99%

NEM Brand Eggshell Membrane Effective in the Treatment of Pain Associated with Knee and Hip Osteoarthritis: Results from a Six Center, Open Label German Clinical Study

Danesch¹

2014

J Arthritis

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“…The eggshell membrane is a natural ingredient obtained from the inner membrane that covers the shell of the egg. Eggshell membranes are composed of fibrous proteins such as collagen type I-V-X [2,3], glucosamine [4], hyaluronic acid (HA) [5], glycosaminoglycans (GAG) like dermatan sulphate and chondroitin sulphate [6] and other components including lysozyme [7], ovotransferrin [8], ovocalixin [9] and desmosine and isodesmosin [10]. Ovomet ® contains naturally the above cited components, all of them being important constituents of joints and playing a crucial role in their health, mobility and flexibility.…”

Section: Ovometmentioning

confidence: 99%

Short-Term Effects of Ovomet®, Eggshell Membrane, in Joint Pain. A Double-Blind and Placebo Study

Gil-Quintana¹,

Fenaux²,

Nuez³

et al. 2018

J Osteopor Phys Act

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“…The egg shell membrane comprises a double layer membrane inside the egg shell, 1) and is composed of about 16% total nitrogen, about 2% total saccharides, 2) and about 1.4% lipid.…”

Section: Improved Physical and Biochemical Features Of A Collagen Memmentioning

confidence: 99%

“…8,9) In particular, cystine is very plentiful, similarly to the case of keratin. 2) We reported previously that protein from egg shell membrane (SEP) can be effectively rendered soluble by a combined treatment of performic acid oxidation and pepsin digestion, and that SEP accelerated the reconstruction of the collagen matrix composed of fibrils with an ordered molecular rearrangement and stable macrostructure. 10) We also reported that 1 mole SEP can be conjugated with 1 mole collagen to reconstruct the matrix, and that an SEPconjugated collagen film with greater thermal stability, more uniform macrostructure and greater flexibility can be obtained from the collagen matrix with SEP than without SEP by drying it and desalting with ethanol, as compared with collagen film.…”

Section: Improved Physical and Biochemical Features Of A Collagen Memmentioning

confidence: 99%

Improved Physical and Biochemical Features of a Collagen Membrane by Conjugating with Soluble Egg Shell Membrane Protein

Ino

Hattori

Yoshida

et al. 2006

Bioscience, Biotechnology, and Biochemistry

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A study of the organic material of hen's-egg shell

Cited by 172 publications

References 37 publications

NEM Brand Eggshell Membrane Effective in the Treatment of Pain Associated with Knee and Hip Osteoarthritis: Results from a Six Center, Open Label German Clinical Study

NEM Brand Eggshell Membrane Effective in the Treatment of Pain Associated with Knee and Hip Osteoarthritis: Results from a Six Center, Open Label German Clinical Study

Short-Term Effects of Ovomet®, Eggshell Membrane, in Joint Pain. A Double-Blind and Placebo Study

Improved Physical and Biochemical Features of a Collagen Membrane by Conjugating with Soluble Egg Shell Membrane Protein

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