A Study of the Interaction between Chitosan and Poly(Ethylene Glycol) by Viscosity Method

Halabalová, Věra; Šimek, Lubomı́r

doi:10.1080/10236660600658336

Cited by 11 publications

(4 citation statements)

References 24 publications

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“…Surprisingly, this trend was not observed among heated α-lac/CH 113 PEG mixtures, where samples containing relatively more protein were more relatively more turbid ( r = 5) or formed precipitates ( r = 10) at pH 5.3 and 5.8 (Figure 1d), which were the only sample mixtures where precipitation occurred. CH forms a rigid-rod conformation through inter-hydrophobic interactions and hydrogen bonding [21,22]. Therefore, the low molecular flexibility among the CH 113 and CH 113 PEG samples would have limited their ability to interact effectively with single proteins because they would be less capable of coiling and conforming to the curvature of the α-lac surfaces [23].…”

Section: Resultsmentioning

confidence: 99%

Impact of Chitosan Molecular Weight and Attached Non-Interactive Chains on the Formation of α-Lactalbumin Nanogel Particles

Juan

Cho

Murphy

et al. 2017

Gels

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Thermal treatment of protein-polysaccharide complexes will form nanogel particles, wherein the polysaccharide controls nanogel formation by limiting protein aggregation. To determine the impact of the chitosan molecular weight and non-interactive chains on the formation of nanogels, mixtures of α-lactalbumin were prepared with selectively-hydrolyzed chitosan containing covalently-attached polyethylene glycol chains (PEG) and heated near the protein's isoelectric point to induce formation of nanogels. Turbidity of heated mixtures indicated the formation of suspended aggregates, with greater values observed at higher pH, without attached PEG, and among samples with 8.9 kDa chitosan. Mixtures containing 113 kDa chitosan-PEG formed precipitating aggregates above pH 5, coinciding with a low-magnitude colloidal charge and average hydrodynamic radii > 400 nm. All other tested mixtures were stable to precipitation and possessed average hydrodynamic radii~100 nm, with atomic force microscopy showing homogeneous distributions of spherical nanogel aggregates. Over all of the tested conditions, attached PEG led to no additional significant changes in the size or morphology of nanogels formed from the protein and chitosan. While PEG may have interfered with the interactions between protein and the 113 kDa chitosan, prompting greater aggregation and precipitation, PEG did not indicate any such interference for shorter chitosan chains.

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Section: Resultsmentioning

confidence: 99%

Impact of Chitosan Molecular Weight and Attached Non-Interactive Chains on the Formation of α-Lactalbumin Nanogel Particles

Juan

Cho

Murphy

et al. 2017

Gels

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“…It has also been reported that m PEGs‐ graft ‐CS spontaneously formed nanometer‐sized aggregates through strong intermolecular hydrogen bonds between the CS moieties . Halabalová and Šimek also reported that dipole–dipole or hydrogen bonding should be responsible for the interaction between CS and PEG in the solution. Therefore, favorable interactions could have occurred between amide or amine nitrogen on the CS backbone and the hydroxyl and etheric oxygen of the PEG.…”

Section: Resultsmentioning

confidence: 94%

Poly(ethylene glycol) methyl ether methacrylate‐graft‐chitosan nanoparticles as a biobased nanofiller for a poly(lactic acid) blend: Radiation‐induced grafting and performance studies

Kongkaoroptham

Piroonpan

Hemvichian³

et al. 2015

J of Applied Polymer Sci

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In this study, we aimed to modify chitosan (CS) as a novel compatible bio-based nanofiller for improving the compatibility including the thermal and mechanical properties of poly(lactic acid) (PLA). The modification of CS with poly(ethylene glycol) methyl ether methacrylate (PEGMA) was done by radiation-induced graft copolymerization. The effects of the dose rate, irradiation dose, and PEGMA concentration on the degree of grating (DG) were investigated. The chemical structure, packing structure, thermal stability, particle morphology, and size of the PEGMA-graft-chitosan nanoparticles (PEGMA-graft-CSNPs) were characterized by fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, and transmission electron microscopy. The compatibility of the PEGMA-graft-CSNP/PLA blends was also assessed by field emission scanning electron microscopy. The PEGMAgraft-CSNPs exhibited a spherical shape with the DG and particle sizes in the ranges of 3-145% and 35-104 nm, respectively. The PEGMA-graft-CSNPs showed compatible with PLA because of the grafted PEGMA segment. A model case study of the PEGMA-graft-CSNP/PLA blend demonstrated the improvement not only the compatibility but also thermal stability flexibility, and ductility of PLA.

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“…Protonation on chitosan-free amino group in the acidic environment caused it to be positively charged. The dipole-dipole or hydrogen bonding between chitosan shell and PEG became stronger than intra-molecular or intermolecular hydrogen bonding of chitosan chain and allowed PEG grafting onto it due to interaction between amine or amide nitrogen of chitosan, and hydroxyl and etheric oxygen of PEG ( 30 ). Probe sonication was employed to reduce particle size as well as improving uniformity of size.…”

Section: Resultsmentioning

confidence: 99%

“…Figure 3 d showed positive linear relationship between zeta potential and amount of chitosan used for developing the nanoparticles. The relationship was predictable since chitosan dissolves in an aqueous solvent, exhibiting net positive charges due to the protonated amine group (30). When the amount of lecithin used decreases, the zeta potential increases, proving that negatively charged lecithin had reacted with positively charged chitosan, producing a negative effect on zeta potential.…”

Section: Zeta Potential Measurementsmentioning

confidence: 97%

PEGylated Lipid Polymeric Nanoparticle–Encapsulated Acyclovir for In Vitro Controlled Release and Ex Vivo Gut Sac Permeation

et al. 2020

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Currently, pharmaceutical research is directed wide range for developing new drugs for oral administration to target disease. Acyclovir formulation is having common issues of short half-life and poor permeability, causing messy treatment which results in patient incompliance. The present study formulates a lipid polymeric hybrid nanoparticles for antiviral acyclovir (ACV) agent with Phospholipon® 90G (lecithin), chitosan, and polyethylene glycol (PEG) to improve controlled release of the drugs. The study focused on the encapsulation of the ACV in lipid polymeric particle and their sustained delivery. The formulation developed for the self-assembly of chitosan and lecithin to form a shell encapsulating acyclovir, followed by PEGylation. Optimisation was performed via Box-Behnken Design (BBD), forming nanoparticles with size of 187.7 ± 3.75 nm, 83.81 ± 1.93% drug-entrapped efficiency (EE), and + 37.7 ± 1.16 mV zeta potential. Scanning electron microscopy and transmission electron microscopy images displayed spherical nanoparticles formation. Encapsulation of ACV and complexity with other physical parameters are confirmed through analysis using Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffraction. Nanoparticle produced was capable of achieving 24-h sustained release in vitro on gastric and intestinal environments. Ex vivo study proved the improvement of acyclovir's apparent permeability from 2 × 10 −6 to 6.46 × 10 −6 cm s −1. Acyclovir new formulation was achieved to be stable up to 60 days for controlled release of the drugs.

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A Study of the Interaction between Chitosan and Poly(Ethylene Glycol) by Viscosity Method

Cited by 11 publications

References 24 publications

Impact of Chitosan Molecular Weight and Attached Non-Interactive Chains on the Formation of α-Lactalbumin Nanogel Particles

Impact of Chitosan Molecular Weight and Attached Non-Interactive Chains on the Formation of α-Lactalbumin Nanogel Particles

Poly(ethylene glycol) methyl ether methacrylate‐graft‐chitosan nanoparticles as a biobased nanofiller for a poly(lactic acid) blend: Radiation‐induced grafting and performance studies

PEGylated Lipid Polymeric Nanoparticle–Encapsulated Acyclovir for In Vitro Controlled Release and Ex Vivo Gut Sac Permeation

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