A Study of the Effects of Hyperbaric Oxygen on the Experimental Spinal Cord Injury

Yeo, John D.; Stabback, S; McKenzie, Bart

doi:10.5694/j.1326-5377.1977.tb99109.x

Cited by 25 publications

(11 citation statements)

References 15 publications

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Section: Resultsmentioning

confidence: 99%

“…In the experimental studies, five of them evaluated the efficacy of HBOT after SCI in rats 21,[23][24][25]29 , two in sheep 27,28 , one in rabbits 26 , and one in cats 22 . The most used SCI model was the weight-drop device technique [22][23][24][27][28][29] . Other models used were the clip compression model 25 , spinal cord transection 21 and ischemia induced by occlusion of a balloon catheter placed into the abdominal aorta 26 .…”

Section: Resultsmentioning

confidence: 99%

“…Many treatment modalities, which prevent the development of damaging effects after the SCI, were investigated [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] . Among these interventions, hyperbaric oxygen therapy (HBOT) has been advocated to improve neurological recovery after brain injury and cerebral ischemia [30][31][32] .…”

Section: Introductionmentioning

confidence: 99%

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Effects of hyperbaric oxygen therapy after spinal cord injury: systematic review

et al. 2009

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OBJECTIVE: to conduct a systematic review of experimental and clinical studies evaluating the effect of hyperbaric oxygen therapy on the spinal cord injury. METHODS: ninety-three studies were identified in the database Pubmed. Among these, through a set of inclusion/exclusion criteria, 11 articles published between 1963 and 2009 were selected. In the nine experimental studies, different ways to apply the treatment were observed. The measured outcomes were: functional, histological, biochemical and electrophysiological. RESULTS: in most of the studies, the results show recovery of locomotor function, histology and/or biochemical features. Regarding the two studies in clinical samples, the results are controversial. The samples are heterogeneous and the application of hyperbaric oxygen therapy is not the same for all patients in each study. CONCLUSION: considering the results of this review, further studies are necessary to define the role of hyperbaric oxygen therapy in acute spinal cord injury.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of hyperbaric oxygen therapy after spinal cord injury: systematic review

et al. 2009

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“…Yeo і співавт. [12] Тип ушкодження (за AOSpine): ушкодженні СМ. Крім того, низка експериментальних досліджень дала змогу виявити інші потенційні механізми нейропротекторного ефекту ГБО [13,14]: 1) пригнічення апоптозу, 2) зменшення оксидантного стресу, 3) зменшення запалення, 4) стимулювання ангіогенезу, 5) зменшення набряку спинного мозку, 6) посилення автофагії тощо.…”

Section: обговоренняunclassified

Hyperbaric oxygenation therapy in treatment of traumatic spinal cord injury: a pilot study

Nekhlopochyn¹,

Voronov²,

Verbov³

2021

Ukr Neurosurg J

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Spinal cord traumatic injury as resulting persistent movement and sensory disorders is one of the most disabling consequences of traumatic factor impact on the human body. Despite a large number of experimental and clinical studies aimed at developing methods for restoring lost functions, there is no acceptable solution to the problem. One of the promising areas in the treatment and rehabilitation of this category of patients is the use of hyperbaric oxygenation (HBO). Experimental models have shown that HBO has a neuroprotective effect in spinal cord injury, but the results of clinical application of the method are still controversial. Objective: to determine the effectiveness of HBO in the complex therapy of victims with traumatic spinal cord injury and the feasibility of further study of this area. Materials and Methods: Study design is a pilot observational retrospective “case – control”. The database of patients with spinal cord injury who were hospitalized at Romodanov Neurosurgery Institute in the period from 2010 to 2020 were used for the analysis. When selecting a control for each clinical case, the following factors were considered: gender, age, circumstances of injury, type of damage to the osteoligamentous apparatus, level of neurological deficit, degree of damage and compression of the spinal cord, time elapsed from the moment of injury to surgery. 28 "case ‒ control" pairs were analyzed. The main criterion for therapy effectiveness was the change in the functional class according to the ASIA scale. Results. Positive dynamics was registered in 57% of victims, including in the group of patients receiving HBO therapy - in 71%, in the control group - in 43%. HBO therapy in the postoperative period significantly affects the dynamics of regression of neurological disorders (p=0.0295). The odds ratio is 3.333 (95% confidence interval - 1.098‒10.116, p=0.0335). The calculation of the odds ratio, adjusted for additional analyzed factors, showed a more pronounced efficiency - 4.519 (95% confidence interval - 1.279‒15.962, p=0.0192). Conclusions. The obtained results indicate that usage of HBO as a method of complex therapy for traumatic spinal cord injury is promising for further study in order to determine the effectiveness of the method, the optimal timing of treatment initiation in the postoperative period and its duration.

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“…Meanwhile, apoptosis in injured spinal cord tissue is significantly reduced after HBO therapy application [13] . Although couples of studies reported HBO therapy had effectiveness on recovery of locomotor dysfunction induced by spinal cord injury [14][15][16] , the mechanism of effect of HBO therapy on traumatic spinal cord injury is still largely unknown. Sirtuin1(SIRT1) protein belongs to a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, which is highly conserved from bacteria to human [17] .…”

Section: Introductionmentioning

confidence: 99%

Activation of SIRT1 by Hyperbaric Oxygenation Promotes Recovery of Motor Dysfunction in Spinal Cord Injury Rats

Chen¹,

Yao²,

Li³

et al. 2020

Preprint

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Background: Emerging evidence demonstrated that hyperbaric oxygenation (HBO) therapy improved the locomotor dysfunction following spinal cord injury (SCI). Sirtuin1(SIRT1) has been characterized as neuroprotection in nerve system. However, whether SIRT1 is involved in alleviation of locomotor function by HBO therapy is unclear. Methods: The Basso, Beattie Bresnahan (BBB) locomotor rating scale was used to evaluate the open-field locomotor function. Western blot, real-time quantitative reverse transcription polymerase chain reaction, SIRT1 activity assay and enzyme-linked immunosorbent assays were performed to explore the molecular mechanisms in adult Sprague-Dawley rats. Results: We found that series HBO therapy significantly improved the locomotor dysfunction and ameliorated the decrease mRNA, protein and activity of spinal cord SIRT1 induced by traumatic SCI injury in rats. In addition, intraperitoneal injection SIRT1 antagonist EX-527 abolished the beneficial effects of series HBO treatment on locomotor deficits and SIRT1 activity loss caused by traumatic SCI injury. However, the rats undergone both series HBO therapy and SIRT1 agonist SRT1720 got the higher BBB score than that undergone series HBO treatment only. Importantly, series HBO treatment following the traumatic SCI injury inhibited the inflammatory cascade and apoptosis-related protein, which was retained by EX-527 and enhanced by SRT1720. Furthermore, EX-527 blocked the enhanced induction of autophagy series with HBO application. Conclusion: These findings demonstrated a new mechanism for series HBO therapy involving activation of SIRT1 and subsequent modulation of inflammatory cascade, apoptosis and autophagy, which contributed to the recovery of motor dysfunction. Key words: HBO, SIRT1, motor dysfunction, inflammation, autophagy, apoptosis

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A Study of the Effects of Hyperbaric Oxygen on the Experimental Spinal Cord Injury

Cited by 25 publications

References 15 publications

Effects of hyperbaric oxygen therapy after spinal cord injury: systematic review

Effects of hyperbaric oxygen therapy after spinal cord injury: systematic review

Hyperbaric oxygenation therapy in treatment of traumatic spinal cord injury: a pilot study

Activation of SIRT1 by Hyperbaric Oxygenation Promotes Recovery of Motor Dysfunction in Spinal Cord Injury Rats

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