A Study of the Effects of L.S.D.: Physiologic and Psychological Changes and Their Interrelations

Dimascio, Alberto; Greenblatt, Milton; Hyde, Robert W.

doi:10.1176/ajp.114.4.309

Cited by 8 publications

(6 citation statements)

References 1 publication

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“…Similar findings were reported in early studies in the 1950s (73)(74)(75)(76)(77). In contrast, LSD (200µg, orally) did not alter diastolic or systolic blood pressure or heart rate in a recent study in eight patients with different chronic life-threatening illnesses (11).…”

Section: Autonomic and Endocrine Effectssupporting

confidence: 87%

Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects

Schmid¹,

Enzler²,

Gasser

et al. 2015

Biological Psychiatry

355

439

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Section: Autonomic and Endocrine Effectssupporting

confidence: 87%

Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects

Schmid¹,

Enzler²,

Gasser

et al. 2015

Biological Psychiatry

355

439

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“…Autonomic changes reflect a stimulation of both branches of the autonomic nervous system. Sympathetic stimulation is evidenced, in most subjects, by a pupillary dilation and light to moderate increases in heart rate and blood pressure (see Table 2) [67,68]; other more inconsistent signs are slight blood‐sugar elevation [69,70] and, rarely, some increase in body temperature. Respiration remains generally unchanged (see Table 3).…”

Section: Pharmacology Of Lsdmentioning

confidence: 99%

“…Other symptoms point to parasympathetic stimulation: diaphoresis and salivation are frequent, nausea may occur, emesis is exceptional, and flushing of the face is more frequent than paleness (see Table 4). Sympathicotonia usually predominates, but there are great individual variations and a marked parasympathicotonia with bradycardia and hypotension are observed in some subjects [18,67]. Temporary headache and near‐syncope have sometimes been reported [35,71].…”

Section: Pharmacology Of Lsdmentioning

confidence: 99%

The Pharmacology of Lysergic Acid Diethylamide: A Review

Passie

Halpern

Stichtenoth

et al. 2008

CNS Neuroscience & Therapeutics

377

319

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Lysergic acid diethylamide (LSD) was synthesized in 1938 and its psychoactive effects discovered in 1943. It was used during the 1950s and 1960s as an experimental drug in psychiatric research for producing so-called "experimental psychosis" by altering neurotransmitter system and in psychotherapeutic procedures ("psycholytic" and "psychedelic" therapy). From the mid 1960s, it became an illegal drug of abuse with widespread use that continues today. With the entry of new methods of research and better study oversight, scientific interest in LSD has resumed for brain research and experimental treatments. Due to the lack of any comprehensive review since the 1950s and the widely dispersed experimental literature, the present review focuses on all aspects of the pharmacology and psychopharmacology of LSD. A thorough search of the experimental literature regarding the pharmacology of LSD was performed and the extracted results are given in this review. (Psycho-) pharmacological research on LSD was extensive and produced nearly 10,000 scientific papers. The pharmacology of LSD is complex and its mechanisms of action are still not completely understood. LSD is physiologically well tolerated and psychological reactions can be controlled in a medically supervised setting, but complications may easily result from uncontrolled use by layman. Actually there is new interest in LSD as an experimental tool for elucidating neural mechanisms of (states of) consciousness and there are recently discovered treatment options with LSD in cluster headache and with the terminally ill.

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“…LSD can cause significant autonomic effects, including blood pressure (systolic and diastolic), heart rate and body temperature. Early studies also reported similar conclusions in the 1950s (Belleville et al., 1956; Dimascio et al., 1957; Forrer & Goldner, 1951; Kornetsky, 1957; Sokoloff et al., 1957). However, a recent study showed no significant changes in diastolic pressure, systolic pressure, or heart rate in eight patients with various chronic life‐threatening after the administration of 200 mcg LSD orally.…”

Section: Discussionmentioning

confidence: 59%

“…Early studies also reported similar conclusions in the 1950s F I G U R E 6 Safety endpoints of autonomic effects for LSD of any drug dose compared with placebo. LSD: lysergic acid diethylamide, SD: standard deviation, CI: confidence interval, IV: inverse variance methods (Belleville et al, 1956;Dimascio et al, 1957;Forrer & Goldner, 1951;Kornetsky, 1957;Sokoloff et al, 1957). However, a recent study showed no significant changes in diastolic pressure, systolic pressure, or heart rate in eight patients with various chronic life-threatening after the administration of 200 mcg LSD orally.…”

Section: Discussionmentioning

confidence: 99%

The potential role of lysergic acid diethylamide for psychological assisted therapy: A meta‐analysis of randomised controlled trials in healthy volunteers

Zhong

Yang

et al. 2021

Human Psychopharmacology

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Objective In recent years, interest in using lysergic acid diethylamide (LSD) in psychiatric research and corresponding therapy has increased rapidly. In this meta‐analysis, we explored the effects of LSD on healthy subjects with respect to subjective drug effects, blood pressure, heart rate, body temperature and side effects. Method PubMed, Embase, and the Cochrane Library were searched from January 2010 to December 2020 for randomized controlled trials (RCTs) on the effects of LSD in healthy people. Subsequently, 5 RCTs with 132 healthy people which focused on the effects of LSD were enrolled in our study. Result We found that taking 50, 100 and 200 mcg LSD doses were associated with a significant increase in the maximal difference from the baseline compared to the placebo group among the outcomes of AMRS (Adjective Mood Rating Scale) score. Significant differences existed between the LSD and placebo groups when taking 100 and 200 mcg LSD in acute adverse effects (100 mcg: SMD = .97, 95% confidence interval [CI], .50, 1.44, Z = 4.04, p < .001; 200 mcg: SMD = 1.18, 95% CI, 0.65, 1.72, Z = 4.32, p < .001). Conclusions Meta‐analysis of the subjective effects of LSD in healthy people revealed moderate significant effect sizes in favor of LSD with no significant adverse effects. A 100 mcg dose of LSD has potential for use in psychological‐assisted therapy and may improve the mental fitness of patients with disease‐related psychiatric distress. Additional clinical trials are necessary to explore the efficacy and safety of LSD as a psychological‐assisted therapy.

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A Study of the Effects of L.S.D.: Physiologic and Psychological Changes and Their Interrelations

Cited by 8 publications

References 1 publication

Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects

Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects

The Pharmacology of Lysergic Acid Diethylamide: A Review

The potential role of lysergic acid diethylamide for psychological assisted therapy: A meta‐analysis of randomised controlled trials in healthy volunteers

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