Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects

Schmid, Yasmin; Enzler, Florian; Gasser, Peter; Grouzmann, Eric; Preller, Katrin H.; Vollenweider, Franz X.; Brenneisen, Rudolf; Müller, Felix; Borgwardt, Stefan; Liechti, Matthias E.

doi:10.1016/j.biopsych.2014.11.015

Cited by 356 publications

(505 citation statements)

References 86 publications

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“…In contrast to a previous study administering 200µg of LSD [6] we did not find significant increases of spiritual experiences in the LSD condition. We assessed spirituality with the spirituality scale of the Affective Neuroscience Personality Scales [43] at screening visit.…”

Section: Discussioncontrasting

confidence: 99%

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The Fabric of Meaning and Subjective Effects in LSD-Induced States Depend on Serotonin 2A Receptor Activation

Preller¹,

Herdener

Pokorny³

et al. 2017

Current Biology

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A core aspect of the human self is the attribution of personal relevance to everyday stimuli enabling us to experience our environment as meaningful [1]. However, abnormalities in the attribution of personal relevance to sensory experiences are also critical features of many psychiatric disorders [2,3]. Despite their clinical relevance, the neurochemical and anatomical substrates enabling meaningful experiences are largely unknown. Therefore, we investigated the neuropharmacology of personal relevance processing in humans by combining fMRI and the administration of the mixed serotonin (5-HT) and dopamine receptor (R) agonist lysergic acid diethylamide (LSD), well known to alter the subjective meaning of percepts, with and without pretreatment with the 5-HT2AR antagonist ketanserin. General subjective LSD effects were fully blocked by ketanserin. In addition, ketanserin inhibited the LSD-induced attribution of personal relevance to previously meaningless stimuli and modulated the processing of meaningful stimuli in cortical midline structures. These findings point to the crucial role of the 5-HT2AR subtype and cortical midline regions in the generation and attribution of personal relevance. Our results thus increase our mechanistic understanding of personal relevance processing and reveal potential targets for the treatment of psychiatric illnesses characterized by alterations in personal relevance attribution. SummaryA core aspect of the human self is the attribution of personal relevance to everyday stimuli

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Section: Discussioncontrasting

confidence: 99%

“…In summary, LSD induced subjective effects as anticipated [6]. All of these LSD-induced effects were blocked by the 5-HT2AR antagonist ketanserin, pointing to the key role of the 5-HT2AR in mediating the human experience of LSD-induced effects.…”

Section: Discussionsupporting

confidence: 57%

The Fabric of Meaning and Subjective Effects in LSD-Induced States Depend on Serotonin 2A Receptor Activation

Preller¹,

Herdener

Pokorny³

et al. 2017

Current Biology

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275

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“…Specifically, MDMA mainly induces the transporter-mediated release of serotonin (Hysek et al 2012) and stimulates oxytocin secretion Ramos et al 2013), which has been implicated in the prosocial effects of MDMA (Ramos et al 2013). Additionally, the serotonin receptor agonist LSD (Rickli et al 2016) stimulated oxytocin secretion (Schmid et al 2015a), produced prosocial effects, and enhanced emotional empathy in the MET (Dolder et al 2016). In contrast to MDMA and LSD and our prediction, the present study found that alcohol did not change oxytocin levels in 30 female and 30 male participants at a low dose (0.27 g/kg) as similarly shown for a high dose of alcohol (0.8 g/kg) in seven male subjects (Bershad et al 2015).…”

Section: Discussionmentioning

confidence: 99%

Alcohol acutely enhances decoding of positive emotions and emotional concern for positive stimuli and facilitates the viewing of sexual images

et al. 2016

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Rationale: Social cognition influences social interactions. Alcohol reportedly facilitates social interactions. However, the acute effects of alcohol on social cognition are relatively poorly studied. Methods: We investigated the effects of alcoholic or non-alcoholic beer on emotion recognition, empathy, and sexual arousal using the dynamic face emotion recognition task (FERT), Multifaceted Empathy Test (MET), and Sexual Arousal Task (SAT) in a double-blind, random-order, cross-over study in 60 healthy social drinkers. We also assessed subjective effects using visual analog scales (VASs), BACs, and plasma oxytocin levels. Results: Alcohol increased VAS ratings of stimulated, happy, talkative, open, and want to be with others. The subjective effects of alcohol were greater in participants with higher trait inhibitedness. Alcohol facilitated the recognition of happy faces on the FERT and enhanced emotional empathy for positive stimuli on the MET, particularly in participants with low trait empathy. Pictures of explicit sexual content were rated as less pleasant than neutral pictures after non-alcoholic beer but not after alcoholic beer. Explicit sexual pictures were rated as more pleasant after alcoholic beer compared with non-alcoholic beer, particularly in women. Alcohol did not alter the levels of circulating oxytocin. Conclusions: Alcohol biased emotion recognition toward better decoding of positive emotions and increased emotional concern for positive stimuli. No support was found for a modulatory role of oxytocin. Alcohol also facilitated the viewing of sexual images, consistent with disinhibition, but it did not actually enhance sexual arousal. These effects of alcohol on social cognition likely enhance sociability.

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“…Furthermore, the prototypical hallucinogen LSD has received renewed attention in psychiatric research (Dolder et al, 2015;Geyer, 2015;Kupferschmidt, 2014;Schmid et al, 2015) and as an adjunct to psychotherapy to treat anxiety (Gasser et al, 2014). Thus, the classic hallucinogens psilocin, DMT, and LSD were also included in the present study to provide more up-to-date basic in vitro pharmacological data on these clinically important substances, including profiles at human receptors, and allow direct comparisons between these classic substances with novel tryptamines and other novel psychoactive substances within the same assays (Liechti, 2015;Rickli et al, 2015a;Rickli et al, 2015b;Rickli et al, 2015c;Simmler et al, 2013;Simmler et al, 2016;Simmler et al, 2014a;Simmler et al, 2014b).…”

Section: Introductionmentioning

confidence: 99%

Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens

Rickli

Moning

Hoener

et al. 2016

European Neuropsychopharmacology

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Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects

Cited by 356 publications

References 86 publications

The Fabric of Meaning and Subjective Effects in LSD-Induced States Depend on Serotonin 2A Receptor Activation

The Fabric of Meaning and Subjective Effects in LSD-Induced States Depend on Serotonin 2A Receptor Activation

Alcohol acutely enhances decoding of positive emotions and emotional concern for positive stimuli and facilitates the viewing of sexual images

Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens

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