1950
DOI: 10.1016/0021-8707(50)90132-8
|View full text |Cite
|
Sign up to set email alerts
|

A study of the effect of various drugs on the whealing reaction

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2

Citation Types

1
3
0

Year Published

1964
1964
1989
1989

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 20 publications
(4 citation statements)
references
References 4 publications
1
3
0
Order By: Relevance
“…The present data, taken in conjunction with the observed poor response of hay fever (Howarth & Holgate, 1984), asthma (White & Eiser, 1983) and urticaria (Mosko & Marshall, 1954) to anti-histamine drugs, suggest that histamine is not the main mediator released by antigen challenge, although it may significantly enhance other mediators. Enalapril increased the flare response to antigen probably by potentiating the effect of bradykinin released during such a reaction.…”
Section: Discussionsupporting
confidence: 49%
“…The present data, taken in conjunction with the observed poor response of hay fever (Howarth & Holgate, 1984), asthma (White & Eiser, 1983) and urticaria (Mosko & Marshall, 1954) to anti-histamine drugs, suggest that histamine is not the main mediator released by antigen challenge, although it may significantly enhance other mediators. Enalapril increased the flare response to antigen probably by potentiating the effect of bradykinin released during such a reaction.…”
Section: Discussionsupporting
confidence: 49%
“…Systemically administered jS2-agonists, theophylline and corticosteroids have previously been shown to have no influence on the skin response to either intradermal antigen or histamine [1][2][3][4]. However, if the area of skin to be challenged is pre-treated with an injection of a jS2-agonist, then this high local concentration attenuates the response to intradermal antigen [5][6][7][8].…”
Section: Introductionmentioning
confidence: 99%
“…It may be that a higher dose of salbutamol is needed since previous studies with oral Iadrenoceptor agonists have shown no suppression of skin test responses (Galant et al, 1973;Spector, 1978;Abramowitz et al, 1980), although the topical application or local injection of these drugs attenuates the response to intradermal antigen presumably by higher local concentrations (Mosko & Marshall, 1954;Ting et al, 1983;Gronneberg et al, 1980). However, the dose of salbutamol used in the present study caused greater systemic side effects than adrenaline and the difference in efficacy between adrenaline and salbutamol in suppressing weal remains unexplained.…”
Section: Discussionmentioning
confidence: 56%