The importance of bradykinin and histamine in the skin response to antigen.

Warren, J. B.; Newman, Christopher M.; Pixley, F.J.; Fuller, R W; Dollery, C. T.

doi:10.1111/j.1365-2125.1988.tb05324.x

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…The present study failed to demonstrate that ACE inhibition augments the cutaneous hypersensitivity reaction to intradermal antigen administration. This is in contrast with the finding, in human volunteers, by Warren et al (1988) that the flare response, although not whealing, was increased, and the demonstration by Lindgren etal. (1987) in guinea pigs that both immediate and late cutaneous hypersensitivity reactions was augmented.…”

Section: Discussioncontrasting

confidence: 99%

Effect of enalapril on allergen‐induced cutaneous hypersensitivity reaction.

Snyman,

Sommers

1991

Brit J Clinical Pharma

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1. To test the hypothesis that the in vivo inhibition of angiotensin converting enzyme in a patient who presents atopy, results in a significant increase in cutaneous bradykinin and prostaglandin production, the effect of enalapril on the cutaneous hypersensitivity reaction was examined in 10 atopic volunteers. 2. A crossover study design was used and volunteers were randomly allocated to treatment with either enalapril (10 mg) alone, or in combination with indomethacin (75 mg), with and without ketotifen (1 mg). Drugs were administered twice daily for 2 days. 3. Allergen (Southern Grass Mix) was administered intradermally 2 h after last drug dosage and the surface areas of the immediate wheal‐and‐flare‐reactions were measured 15 min later. The late phase of the cutaneous response was evaluated 6 h later by determining skinfold thickness and surface area. 4. Enalapril alone had no effect on any of the parameters measured. 5. The cutaneous hypersensitivity reaction was significantly reduced with regard to both immediate and late cutaneous responses when the indomethacin and ketotifen combination was added to enalapril therapy. 6. When only indomethacin was added to enalapril pretreatment the flare reaction was significantly reduced, but whealing was unaffected. 7. This study presents further evidence that mast cell mediators other than prostaglandins are involved in the cutaneous hypersensitivity reaction. Furthermore, that endogenous bradykinin production after enalapril pretreatment either never reaches the supraphysiological concentrations used in previous experiments, or that bradykinin is rapidly and effectively broken down to inactive peptides by other carboxypeptidase enzymes.

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Section: Discussioncontrasting

confidence: 99%