A study of the effect of orchidectomy on the melanocytes and melanin in the skin of the guinea-pig

Snell, Richard S.; Bischitz, P. G.

doi:10.1007/bf00342369

Cited by 19 publications

(4 citation statements)

References 12 publications

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“…Melanocytes of young and adult camels had several processes containing numerous melanin granules extended between neighboring keratinocytes. Snell and Bischitz (1959) found the same results in Guinea pig epidermis in which dendritic processes of melanocytes were sandwiched between adjacent keratinocytes.…”

Section: Discussionsupporting

confidence: 62%

Non-keratinocytes of Egyptian Camel (Camelus dromedarius)

Zaghloul

Derbalah

2011

Journal of Veterinary Anatomy

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The skin of five male Egyptian camels (Camelus dromedarius) between 10 and15 years old and five male camels between 3 and5 years old were collected and prepared for transmission electron microscopy to study the non-keratinocytes. The melanocytes of camel skin were more numerous in adult camels than in young ones, with a higher number of melanin granules in adults. Merkel cells of camel skin had lobulated nuclei mainly in adult camels, which had also a higher number of dense cored granules than the young ones. But intranuclear rodlets were observed only in young camel skin. The Langerhans cells of adult camel skin were greater in number than in young ones. Round nuclei of Merkel cells were seen only in adult skin. Langerhans cell granules were detected but without a clear racquet shape: rod shapes only could be detected in cross, oblique and longitudinal sections and they were surrounded by a trilaminar membrane. The Langerhans cell granules were few in number inside each cell. All these findings might suggest that the skin is well adapted to protect the animal against harmful effect of the ultraviolet rays of the Egyptian desert environment. This effect mainly increased with age.

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Section: Discussionsupporting

confidence: 62%

Non-keratinocytes of Egyptian Camel (Camelus dromedarius)

Zaghloul

Derbalah

2011

Journal of Veterinary Anatomy

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“…In the present study, we found that the melanocytes had dendrites near the keratinocytes for transportation of melanin pigment to these cells. This result comes in alignment with that obtained by (Simon & Różanowska, 2008; Snell & Bischitz, 1959). Inside the melanocytes of snout skin of the domestic pig ( Sus scrofa domesticus ), the melanosomes were presented in four stages; the first stage appeared light and rounded, while in the second and third stages, they appeared elongated, but the third stage appeared darker and in the fourth stage, they appeared rounded and electron dense.…”

Section: Discussionsupporting

confidence: 92%

Snout cutis of the domestic pig (Sus scrofa domesticus, Linnaeus, 1758): Using light and transmission electron microscopy

Hanafy

Abumandour

Massoud

et al. 2022

Microscopy Res & Technique

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“…The greatest effect was seen in the areola where in addition to definite morphological changes in the melanocytes and in the reduction of melanin there was also a significant reduction in cell counts. The increase in the amount of melanin found in the sole of the foot would appear to be explained by the stimulating effect on melanogenesis known to follow the operative procedure of the initial skin biopsy; this effect on melanogenesis has been fully reported previously [Snell & Bischitz, 1959].…”

Section: Effect Of Progesterone On Melanocytes and Melanin In Ovariecmentioning

confidence: 93%

“…The increase in the sole of the foot, however, was found to be no greater than that which follows the operative procedure associated with skin removal [Snell & Bischitz, 1959].…”

Section: Effect Of Progesterone On Melanocytes and Melanin In Ovariecmentioning

confidence: 96%

A Study of the Effect of Ovariectomy, Oestrogen and Progesterone on the Melanocytes and Melanin in the Skin of the Female Guinea-Pig

Bischitz¹,

Snell²

1960

Journal of Endocrinology

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1. The effects of ovariectomy, oestrogen and progesterone on the melanocytes and melanin in the skin of the ear, anterior abdominal wall, areola, and sole of foot have been studied in pure black and pure red guinea-pigs.2. Following ovariectomy the melanin content of the melanocytes was reduced and many of the melanocytes became smaller in size and had shortened dendritic processes. Some melanocytes had a deformed appearance, which varied from a minor irregularity of the cell contour to an advanced degree of cell collapse with fragmentation of the dendritic processes. A significant reduction of the melanocyte count occurred only in the areola, and this was accompanied by a reduction in the amount of free melanin.3. In the ovariectomized animals which received oestrogen the amount of melanin was increased both inside and outside the melanocytes in all the regions. The greatest increase occurred in the areola where it was mainly due to a large increase of free melanin. In the nonsexual skin areas there was a smaller increase of free melanin but a greater increase in melanin within the melanocytes. No statistically significant changes in the counts were produced in any of the skin regions. 4. In the ovariectomized animals which received progesterone the amount and depth of colour of the melanin increased both within and outside the melanocytes and this was most marked in the ear. No statistically significant changes in the counts were produced in any of the skin regions. The general effect produced by progesterone was found to be less than that which occurred after oestrogen.Numerous workers have reported that oestrogens can stimulate melanogenesis in the skin in a wide variety of species. Little work, however, has been done on the influence of progesterone on this process, and it would appear from a review of the literature that the effect of ovariectomy on melanogenesis in animals has never been investigated. Many of the observations on the influence of the female sex hormones on pigment formation have been macroscopic only and microscopical studies have been confined to vertical skin sections. Vertical sections have the disadvantage that accurate melanocyte counts are impossible and that the appearances of the melano¬ cytes cannot be adequately demonstrated. The present paper describes a histochemical investigation into the appearances of the melanocytes in the skin of the female guinea-pig following ovariectomy and administration of oestrogen or proge¬ sterone, using both skin sheets and vertical sections. It 'was hoped to establish

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A study of the effect of orchidectomy on the melanocytes and melanin in the skin of the guinea-pig

Cited by 19 publications

References 12 publications

Non-keratinocytes of Egyptian Camel (Camelus dromedarius)

Non-keratinocytes of Egyptian Camel (Camelus dromedarius)

Snout cutis of the domestic pig (Sus scrofa domesticus, Linnaeus, 1758): Using light and transmission electron microscopy

A Study of the Effect of Ovariectomy, Oestrogen and Progesterone on the Melanocytes and Melanin in the Skin of the Female Guinea-Pig

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