A study of the application of TAP combined with transvaginal ultrasound in the diagnosis of early-stage endometrial cancer

Ma, Anjun; Fan, Dianxia; Yan, Fangli

doi:10.3892/ol.2018.9250

Cited by 12 publications

(14 citation statements)

References 22 publications

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“…Studies performed recently have proven that TAP remarkably affects cancer development and progression and regulates cell growth in terms of proliferation and apoptosis (7)(8)(9). Gastric carcinoma patients presented an obvious TAP upregulation relative to healthy participants.…”

Section: Discussionmentioning

confidence: 96%

High Expression of Tumor Abnormal Protein Preoperatively Predicts Poor Prognosis of Patients With Esophageal Squamous Cell Carcinoma

et al. 2021

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Background: Esophageal squamous cell carcinoma (ESCC) acts as a fatal malignant tumor among human beings and is marked by late-stage diagnosis, frequent recurrence, metastasis, and therapy resistance. Tumor abnormal protein (TAP) remarkably affects cancer development and progression of human cancers. TAP has been shown to be a biomarker for gastric and lung cancer progression. Nevertheless, the clinical value exhibited by TAP for ESCC has not been well-explained in the current literature.Methods: The present study included 183 ESCC cases who received surgical resection and 183 cases who had normal physical checkup from March 2013 to January 2015 at the People's Hospital of Chizhou, and used the TAP detection agent for evaluating the TAP relative level.Results: As found, ESCC patients presented an obviously higher TAP expression relative to cases who had normal physical checkup. Moreover, TAP expression was significantly downregulated after surgery. Furthermore, the TAP expression was correlated with gender, smoking, pathologic differentiation, and pN stage, but not with age, tumor location, surgical type, pT stage, and vascular invasion. High expression of TAP was significantly correlated with poorer overall survival (OS) rate in ESCC patients. TAP was an independent prognostic predictor in ESCC patients, based on the multivariate survival analysis.Conclusion: The study reveals how TAP upregulation promotes ESCC malignant progression, and concludes that TAP acts as the therapeutic target and potential biomarker specific to ESCC.

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Section: Discussionmentioning

confidence: 96%

High Expression of Tumor Abnormal Protein Preoperatively Predicts Poor Prognosis of Patients With Esophageal Squamous Cell Carcinoma

et al. 2021

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“…Approximately 70% of proteins in vivo have glycosylation modifications [8]. It has been reported that TAP plays an important role in improving the diagnosis of cancerous tumors, such as bladder, gastric, thyroid, colorectal, and endometrial cancers [9][10][11][12][13].…”

Section: Discussionmentioning

confidence: 99%

The use of TAP for the primary diagnosis of renal cell carcinoma

Jiang

Liu

et al. 2019

Preprint

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Objective To study the value of TAP expression in peripheral blood for early diagnosis of renal cell carcinoma. Materials and Methods TAP expression was analyzed in the peripheral blood of 45 patients with renal cell carcinoma, 32 patients with benign renal lesions and 42 healthy patients. An analysis of the relationship between TAP expression and the clinicopathological features in renal cell carcinoma was performed; the ROC curve was used to evaluate the diagnostic efficacy of TAP detection for renal cell carcinoma diagnosis. Results TAP levels were significantly higher in RCC patients than in patients with nonneoplastic diseases. We also found that the rate of positive TAP expression in the peripheral blood of the renal cell carcinoma group showed no significant difference when evaluated by age, sex, histological grade, tumor stage, tumor size or tumor location (P > 0.05). The area under the ROC curve was 0.92 (95% CI: 0.82-0.95), and the sensitivity and specificity in the diagnosis of RCC was 73% and 91%, respectively. Conclusions The expression of TAP in peripheral blood of patients with renal cell carcinoma was significantly higher than that in nonneoplastic patients, which may provide an effective means of primary diagnosis for renal cell carcinoma

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“…Due to convenient detection, sensitivity and broad spectrum, TAP detection has been routinely performed to many hospitalized patients, as well as in physical examination population. At present, some reports [4,5,6] demonstrated that TAP was closely related to a variety of tumors. Ma, et al [4] found that TAP combined with transvaginal ultrasound had a higher accuracy for the diagnosis of early endometrial cancer.…”

Section: Introductionmentioning

confidence: 99%

“…At present, some reports [4,5,6] demonstrated that TAP was closely related to a variety of tumors. Ma, et al [4] found that TAP combined with transvaginal ultrasound had a higher accuracy for the diagnosis of early endometrial cancer. Zhang et al [5] found that TAP contributed to the initial diagnosis of bladder cancer.…”

Section: Introductionmentioning

confidence: 99%

Tumor Abnormal Protein Detection is An Effective Screening Method for Solid Malignancies

Zhang

Tian

Zhang

et al. 2021

Preprint

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Background: Detection of tumor abnormal protein (TAP) is a recently developed but not widely used method for screening malignancies. This study is aimed to assess the ability of TAP level in distinguishing solid malignancies. Methods: The TAP levels were compared between malignancies and benign disease patients, and the distinguish ability were evaluated by receiver operating characteristic (ROC) curve analysis. We further analyzed TAP levels in physical examination populations with different genders and age， and compared clinical parameters in TAP positive and negative groups. Results: We found that TAP levels were getting higher from benign to precancerous lesions and to malignancies, and TAP levels were decreased after tumor resection. ROC curve analysis showed that TAP levels might aid to distinguish between malignancies and benign diseases. In the physical examination populations, the positive ratio of TAP was 3.7% (4.6% to female and 3.1% to male), and the TAP levels were higher in female. The TAP levels in populations above 60 year age were higher than those in less than 60 years, which increased with age. The hemoglobin levels were lower in TAP positive populations. Conclusion: TAP was an effective biomarker of screening and following-up for malignancies. There may be some potential links between TAP and hemoglobin, which deserve further studies.

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A study of the application of TAP combined with transvaginal ultrasound in the diagnosis of early-stage endometrial cancer

Cited by 12 publications

References 22 publications

High Expression of Tumor Abnormal Protein Preoperatively Predicts Poor Prognosis of Patients With Esophageal Squamous Cell Carcinoma

High Expression of Tumor Abnormal Protein Preoperatively Predicts Poor Prognosis of Patients With Esophageal Squamous Cell Carcinoma

The use of TAP for the primary diagnosis of renal cell carcinoma

Tumor Abnormal Protein Detection is An Effective Screening Method for Solid Malignancies

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