High Expression of Tumor Abnormal Protein Preoperatively Predicts Poor Prognosis of Patients With Esophageal Squamous Cell Carcinoma

Abstract

Background: Esophageal squamous cell carcinoma (ESCC) acts as a fatal malignant tumor among human beings and is marked by late-stage diagnosis, frequent recurrence, metastasis, and therapy resistance. Tumor abnormal protein (TAP) remarkably affects cancer development and progression of human cancers. TAP has been shown to be a biomarker for gastric and lung cancer progression. Nevertheless, the clinical value exhibited by TAP for ESCC has not been well-explained in the current literature.Methods: The present study included 183 ESCC cases who received surgical resection and 183 cases who had normal physical checkup from March 2013 to January 2015 at the People's Hospital of Chizhou, and used the TAP detection agent for evaluating the TAP relative level.Results: As found, ESCC patients presented an obviously higher TAP expression relative to cases who had normal physical checkup. Moreover, TAP expression was significantly downregulated after surgery. Furthermore, the TAP expression was correlated with gender, smoking, pathologic differentiation, and pN stage, but not with age, tumor location, surgical type, pT stage, and vascular invasion. High expression of TAP was significantly correlated with poorer overall survival (OS) rate in ESCC patients. TAP was an independent prognostic predictor in ESCC patients, based on the multivariate survival analysis.Conclusion: The study reveals how TAP upregulation promotes ESCC malignant progression, and concludes that TAP acts as the therapeutic target and potential biomarker specific to ESCC.

Quantification of Tumor Abnormal Proteins in the Diagnosis and Postoperative Prognostic Evaluation of Gastric Cancer

“…This indicates that the increased TAP is related to the poor prognosis of GC patients after surgery, which is consistent with previously reported. 21 …”

Preoperative Tumor Abnormal Protein as a Promising Biomarker to Predict Oncological Outcome of Hepatocellular Carcinoma After Curative Resection

“…In recent years, several studies suggested that there was a close relationship between TAP and the prognosis of patients with various cancers. For example, Wu et al [12]indicated that TAP could be regarded as a prognostic factor for NSCLC patients, and Yao et al [13] revealed that high preoperative TAP level could predict the poor outcome of patients with esophageal squamous cell carcinoma. In line with these ndings, this study suggested that there was a positive correlation between higher preoperative TAP and prognosis of HCC after curative resection, and multivariate analysis con rmed that it was a signi cant prognostic factor of RFS.…”

“…When TAP presents in blood, it will react with detection reagent (Abnormal Sugar Chain Structure of Glycoproteins) and generates a crystal-like condensation product. According to previous studies [13], TAPpositive was de ned as condensation particle area ≥ 225 µm 2 , TAP weakly positive was de ned as the condensation particle area was between 121 and 225 µm 2 , and as for TAP-negative, there was no crystallike condensation product. In the present study, high expression group has a condensation particle area that was ≥ 225 µm 2 , and low expression group has a condensation particle area that was < 225 µm 2 .…”

“…According to the cut-off value of TAP level mentioned in previous literatures [13], the whole population was categorized into the TAP high group (TAP ≥ 225 µm 2 ) and TAP low group (TAP < 225 µm 2 ). As shown in Fig.…”

“…For example, Huang et al [9] demonstrated that TAP can be considered as a signi cant indicator for clinically monitoring colorectal cancer patients, and Ma et al [10]suggested that TAP has high accuracy in the diagnosis of early-stage endometrial cancer when combined with transvaginal ultrasound. In addition, a few literatures showed that TAP can act as a prognostic factor in different kinds of cancer, such as non-small cell lung cancer (NSCLC), gastric cancer and esophageal squamous cell carcinoma [11][12][13]. However, as far as we know, up to now, no data indicated that there was a correlation between TAP and the oncological outcome of HCC after radical hepatectomy.…”