A Study of the Antioxidant Effect of Alpha Lipoic Acids on Sperm Quality

Ibrahim, Siti Fatimah; Osman, Khairul; Das, Srijit; Othman, Abas Mazni; Majid, Norzaiti Abdul; Rahman, Mohd Padzil Abdul

doi:10.1590/s1807-59322008000400022

Cited by 81 publications

(46 citation statements)

References 18 publications

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“…It has recently been reported that antioxidant capacity diminished in human semen depending on exposure to cellphone radiation, and as a result, fertilization potential could be diminished or destroyed (11,14,15). On the other hand, it is stated that the effect of antioxidant substances can improve sperm quality and increase fertility (16,17).…”

Section: Introductionmentioning

confidence: 99%

Inhibition by Egb761 of the effect of cellphone radiation on the male reproductive system

Gevrek¹,

Aydın²,

Ozsoy³

et al. 2017

BLL

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OBJECTIVES: To determine the effects of Egb761 on testicular tissues and semen parameters in rats exposed to cellphone waves. BACKGROUND: EGb761 has antioxidant properties as a free-radical scavenger. Cellphone electromagnetic radiation (EMR) induces oxidative stress in cells. METHODS: Twenty-one Wistar albino male adult rats were divided into three groups (control, experimental, treatment), including seven rats in each. The experimental and treatment groups were exposed to cellphone EMR (0.96 W/kg) for six weeks (4 hrs/day). Egb761 (100 mg/kg/day) was also added to the treatment. Testes, epididymal semen and blood plasma were used for analysis. RESULTS: Exposure to cellular phone radiation resulted in a signifi cant impairment in testicular morphometry and histological structure, reduction of total and motile sperm numbers and plasma testosterone level. Egb761 administration improved testicular damage and led to a marked increase in plasma testosterone levels and total and motile sperm numbers. CONCLUSION: Male reproductive system is susceptible to cellphone radiation. Cellphone waves induce toxic effects in testicular tissues, impair spermatogenesis and cause an imbalance in testosterone hormone levels. Egb761 ameliorated these toxic effects by reversing testicular tissue damage, restoring normal spermatogenesis and hormone levels. This suggests that Egb761 is a potential therapeutic agent against EMR-induced male reproductive toxicity (Tab. 3, Fig. 6, Ref. 45). Text in PDF www.elis.sk.

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Section: Introductionmentioning

confidence: 99%

Inhibition by Egb761 of the effect of cellphone radiation on the male reproductive system

Gevrek¹,

Aydın²,

Ozsoy³

et al. 2017

BLL

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“…ALA is an antioxidant that enhance the capacity of sperm in tolerating a higher volume of free radical attack. ALA has the ability to create a robust shield on the cell membrane, therefore it is maintaining the structural integrity of sperm cell membrane [12].…”

Section: Amentioning

confidence: 99%

Sperm quality after swim up and density gradient centrifugation sperm preparation with supplementation of alpha lipoic acid (ALA): A preliminary study

Lestari

Pujianto

2018

AIP Conference Proceedings

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“…das Glutathion reduziert [64]. Inkubation von Ziegenspermatozoen mit α-Liponsäure zeigten eine signifikante Zunahme der Motilität [65].…”

Section: Tab 4 Medikamentöse Therapie Bei Ejakulationsstörungen Und unclassified

Drug therapy options for oligoasthenoteratozoospermia syndrome

Trottmann

Köhn²,

Dickmann

et al. 2011

Urologe

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Medical treatment of oligoasthenoteratozoospermia (OAT) syndrome includes many different treatment concepts. The targeted causes in the treatment of OAT syndrome are either hormonal, as for example hypothalamic, pituary, or, seldom, hyperprolactinemic disturbances, or acute or chronic urogenital infections, as well as ejaculatory disorders. Often no pathogenic reason for OAT syndrome can be found and targeted. Most treatment concepts in the past tried to improve sperm quality. Administration of antiestrogens, antioxidants, hormones, and micronutrients has been tried and used to improve sperm quality. The present article provides an overview of current medical treatment options for OAT syndrome, including former unsuccessful treatment concepts. The article furthermore sketches out potential treatment options, which might be available in the future.

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A Study of the Antioxidant Effect of Alpha Lipoic Acids on Sperm Quality

Cited by 81 publications

References 18 publications

Inhibition by Egb761 of the effect of cellphone radiation on the male reproductive system

Inhibition by Egb761 of the effect of cellphone radiation on the male reproductive system

Sperm quality after swim up and density gradient centrifugation sperm preparation with supplementation of alpha lipoic acid (ALA): A preliminary study

Drug therapy options for oligoasthenoteratozoospermia syndrome

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