Wet ethanol is a biofuel with unique fuel properties: a high latent heat of vaporization and low equivalence ratio sensitivity. These two fuel properties enable control over the heat release process in low temperature combustion through the enhancement of in-cylinder thermal stratification. In this work, it is shown that the direct injection of wet ethanol 80 (80% ethanol, 20% water, by mass) during the intake stroke on a mid-compression ratio engine with a side-mounted gasoline direct injector does not fully premix with incoming air, leaving stratification in the cylinder which elongates the combustion process, enabling high-load low temperature combustion without engine-damaging knock. As a result, the load under naturally aspirated conditions was only limited by oxygen content as the global equivalence ratio approached stoichiometry. The results show that swirl can not only modulate the induced stratification effectively by increasing the amount of bulk motion in the cylinder but also cause a thermal efficiency penalty, since swirl increases heat transfer losses. Modulation over the induced stratification can be achieved without an efficiency penalty by employing either a dual injector system where a fraction of the total fuel is injected into the port or a split injection strategy where a fraction of the total fuel is injected during the compression stroke. This strategy enables high-load low temperature combustion, while reducing the number of regions that form NOx and avoiding excessively rich regions that contribute to combustion inefficiency.