A Study of Surface Modification of Poly(lactic-co-glycolic) Acid Using Argon Ion Irradiation

Abstract

The effect of Argon ion irradiation to the surface properties of poly(lactic-co-glycolic) acid (PLGA) was studied. A beam of 170 keV Argon ions was implanted at different fluencies (1 × 10 12 , 1 × 10 13 , 1 × 10 14 , and 1 × 10 15 ions/cm 2). X-ray photoelectron spectroscopy (XPS) was used to analyze the evolution of the bonding microstructure of PLGA due to irradiation. Surface morphology was monitored using atomic force microscopy (AFM). AFM analysis shows that film roughness increased to maximum at the dose of 1 × 10 14 ions/cm 2 where the formations of hillocks were also detected. Hydrophilicity of PLGA is important for their applications in biomedicine such as bioscaffolds. Hydrophilicity was monitored using water contact angle measurements for both unmodified and ion-modified PLGA. It was observed that hydrophilicity of PLGA changes with the ion irradiation. This demonstrates that ion irradiation can be an alternative approach to control hydrophilicity of PLGA. PLGA scaffolds modified with ion irradiation could therefore be more suitable for the biomedical applications.

Surface Modification of Electrospun Bioresorbable and Biostable Scaffolds by Pulsed DC Magnetron Sputtering of Titanium for Gingival Tissue Regeneration

“…Three distinct peaks are present in the C1s spectrum of the u-PLGA scaffold. The first peak (marked in red) at an energy value of 284.9 eV indicates the presence of C-C/C-H bonds, and the second and third peaks (marked in blue and green) located at 286.8 and 288.8 eV, indicating the presence of C-O and O-C=O bonds, respectively [44][45][46].…”

Surface topographical and structural analysis of Ag+-implanted polymethylmethacrylate

“…As a result of chain scission, gases such as H 2 , CO, and CH 4 are released along the ion tracks [30]. These gases diffuse and are trapped by the ion-produced damages along the ion track, forming hillocks and craters on the surface of the implanted polymer [31].…”

Surface modification of poly (lactic-co-glycolic) acid multiwall carbon nanotubes based on microwave radiation

“…Some of these include the use of electromagnetic waves, ion irradiation, and chemical functionalization. 9,12,13 The benefits of each of these processes depend on the materials and their intended application. For most of the PLGA-based applications including biomedicine, the surface behavior of the device is critical for its best performance.…”