A Study of Single Nucleotide Polymorphisms of Tumour Necrosis Factor α-1031 And Tumour Necrosis Factor β+ 252 in Chronic Rhinosinusitis

Misron, Khairunnisak; Hamid, Suzina Sheikh Ab; Ahmad, Azlina; Ramli, Ramiza Ramza

doi:10.21053/ceo.2016.01732

Cited by 4 publications

(4 citation statements)

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“…This leads to a possibility that variation exists between the ethnicity affecting frequency of many genetic alleles [16]. Besides that, this lack of association between IL-1A (+4845G, +4845T) gene polymorphism and CRSwNP or CRSsNP, maybe contributed by epigenetic factors such as environmental factor interacting within the genome and immunologic process modified by immunomodulator prescribed to the patient [1021]. For example, macrolides used in treatment of CRSwNP, may inhibit neutrophilic rather than eosinophilic activity and macrophage activation, and lower the IL-1B concentration [22].…”

Section: Discussionmentioning

confidence: 99%

“…CRS is a complex disease whereby the actual pathogenesis is still under active investigation and is believed to be of a multifactorial. The inflammatory reaction of the sinonasal mucosal lining causing mucosal oedema which obstructs the sinus ostia, leading to mucus retention and infection, hence development of CRS [10]. Among the predisposing factors associated with this disease are asthma, aspirin sensitivity, allergy, atopy, cigarette smoking and genetic factor [1].…”

Section: Introductionmentioning

confidence: 99%

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Association of IL-1 gene polymorphisms with chronic rhinosinusitis with and without nasal polyp

Mohamad

Hamid

Ahmad

et al. 2019

Asia Pacific Allergy

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Background Chronic rhinosinusitis (CRS) is one of the most common and complex chronic inflammatory disease of sinonasal mucosa. Even though the pathogenesis of CRS is multifactorial and still unclear, the role of cytokines especially interleukin-1 (IL-1) is being investigated worldwide in different population because of varying results obtained. Objective To study the association of IL-1 ( A and B ) gene polymorphisms with chronic rhinosinusitis with nasal polyp (CRSwNP) and without nasal polyp (CRSsNP), and other factors related. Methods This is a case-controlled study which include a total of 138 subjects recruited from Otorhinolaryngology-Head and Neck Surgery clinic in Hospital Universiti Sains Malaysia. Genotyping of the IL-1A (+4845G, +4845T) and IL-1B (−511C, −511T) were performed with restriction fragment length polymorphism analysis. Results There was a statistical significant association between IL-1B (−511C, −511T) polymorphism with CRSwNP and CRSsNP ( p < 0.001). The CT genotype of IL-1B was markedly increased in CRSwNP subjects (52.2%). However, there was no significant association found between IL-1A (+4845G, +4845T) with CRSwNP and CRSsNP ( p = 0.093). No association was found in factors related to CRS, which included asthma, atopy, allergy, aspirin sensitivity, and family history of nasal polyp ( p value of 0.382, 0.382, 0.144, >0.95, and 0.254, respectively). Conclusion This study indicates an association of IL-1B (−511C, −511T) polymorphism with CRSwNP and CRSsNP in our population, hence there is a possibility of IL-1B involvement in modulating pathogenesis of CRS. There was no significant association of IL-1A (+4845G, +4845T) polymorphism with CRSwNP and CRSsNP, and other factors related.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of IL-1 gene polymorphisms with chronic rhinosinusitis with and without nasal polyp

Mohamad

Hamid

Ahmad

et al. 2019

Asia Pacific Allergy

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“…TNF‐α is involved in a variety of signal transduction pathways, exerts pleiotropic effects that regulate nuclear transcription factors, and can mediate and regulate different target genes in a variety of cell types 33 . Polymorphism of the TNFα‐1031 gene might be significantly correlated with the incidence of atopic CRS 34 . Peter et al 35 .…”

Section: Characteristics Of Mucin Hypersecretion In Different Endotyp...mentioning

confidence: 99%

Characteristics of mucin hypersecretion in different inflammatory patterns based on endotypes of chronic rhinosinusitis

Zhai,

Shao,

et al. 2024

Clinical & Translational All

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BackgroundChronic rhinosinusitis (CRS) is usually accompanied by mucin hypersecretion that can lead to mucus accumulation and impair nasal mucociliary clearance, thus exacerbating airway inflammation. Abnormal mucin hypersecretion is regulated by different T helper (Th) cytokines, which are associated with different endotype‐driven inflammatory responses. Therefore, it is of great significance to understand how these factors regulate mucin hypersecretion to provide precise treatment strategies for different endotypes of CRS.BodyThus far, the most common endotypes of CRS are classified as type 1, type 2, or type 3 immune responses based on innate and adaptive cell‐mediated effector immunity, and the representative Th cytokines in these immune responses, such as IFN‐γ, TNF‐α, IL‐4, IL‐5, IL‐13, IL‐10, IL‐17, and IL‐22, play an important regulatory role in mucin secretion. We reviewed all the related literature in the PubMed database to determine the expression of these Th cytokines in CRS and the role they play in the regulation of mucin secretion.ConclusionWe believe that the main Th cytokines involved in specific endotypes of CRS play a key role in regulating abnormal mucin secretion, which contributes to better understanding of the pathogenesis of CRS and provides therapeutic targets for airway inflammatory diseases associated with mucin hypersecretion.

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“…TNF-a promoter polymorphisms may play a genetic role in susceptibility and progression of vitiligo [Laddha et al, 2012], as well as being reported as being a risk factor in schizophrenia in certain populations such as in that of Saudi Arabian patients [Kadasah et al, 2017]. Additionally TNFa-1031 gene polymorphisms may be related with chronic higher susceptibility to chronic rhinosinusitis [Misron et al, 2017]. Based on numerous reports, polymorphism in TNF-a has been shown to have devastating effects.…”

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confidence: 99%

Associations of TNF‐α ‐238 A/G and IL‐10 ‐1082 G/A Genetic Polymorphisms With the Risk of NONFH in the Chinese Population

Wei

Zhi

Wei

et al. 2017

J of Cellular Biochemistry

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The study aims to explore the roles of common polymorphisms of Tumor Necrosis Factor-α (TNF-α) (-238 A/G and -308 A/G) and IL-10 (-819 T/C and -1082 G/A) genes in the risk of non-traumatic osteonecrosis of the femoral head (NONFH). One hundred and forty-seven NONFH patients and 135 healthy individuals were selected as the case and control groups. qRT-PCR and Western blotting techniques detected mRNA as well as protein expressions of TNF-α and IL-10 of each genotype in both the case and control groups. The GA genotype and the A allele of TNF-α -238 A/G were higher in the case group than in the control group. Compared with the control group, AA, GA, and AG + AA genotypes as well as the A allele of IL-10-1082 G/A were all lower in the case group. In the case groups increased levels of TNF-α as well as decreased levels of IL-10 expression when compared with the control group. TNF-α expression of TNF-α-238 GA genotype was significantly higher than that in patients with GG genotype, while the IL-10 expression of GA and AA genotypes of IL-10-1082 was significantly lower than in that of patients with the GG genotype. TNF-α protein expression in the GA genotype was significantly higher than in the GG genotype. In relation to TNF-α -238, TNF-α protein expression of GA and AA genotypes had significantly reduced more so than the GG genotype in IL-10-1082. TNF-α-238 A/G and IL-10-1082 G/A may be involved as risk factors of NONFH. J. Cell. Biochem. 118: 4872-4880, 2017. © 2017 Wiley Periodicals, Inc.

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A Study of Single Nucleotide Polymorphisms of Tumour Necrosis Factor α-1031 And Tumour Necrosis Factor β+ 252 in Chronic Rhinosinusitis

Cited by 4 publications

References 29 publications

Association of IL-1 gene polymorphisms with chronic rhinosinusitis with and without nasal polyp

Association of IL-1 gene polymorphisms with chronic rhinosinusitis with and without nasal polyp

Characteristics of mucin hypersecretion in different inflammatory patterns based on endotypes of chronic rhinosinusitis

Associations of TNF‐α ‐238 A/G and IL‐10 ‐1082 G/A Genetic Polymorphisms With the Risk of NONFH in the Chinese Population

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