Association of IL-1 gene polymorphisms with chronic rhinosinusitis with and without nasal polyp

Abstract

Background Chronic rhinosinusitis (CRS) is one of the most common and complex chronic inflammatory disease of sinonasal mucosa. Even though the pathogenesis of CRS is multifactorial and still unclear, the role of cytokines especially interleukin-1 (IL-1) is being investigated worldwide in different population because of varying results obtained. Objective To study the association of IL-1 ( A and B ) gene polymorphisms with chronic rhinosinusitis with nasal polyp (CRSwNP) and without nasal polyp (CRSsNP), and other factors related. Methods This is a case-controlled study which include a total of 138 subjects recruited from Otorhinolaryngology-Head and Neck Surgery clinic in Hospital Universiti Sains Malaysia. Genotyping of the IL-1A (+4845G, +4845T) and IL-1B (−511C, −511T) were performed with restriction fragment length polymorphism analysis. Results There was a statistical significant association between IL-1B (−511C, −511T) polymorphism with CRSwNP and CRSsNP ( p < 0.001). The CT genotype of IL-1B was markedly increased in CRSwNP subjects (52.2%). However, there was no significant association found between IL-1A (+4845G, +4845T) with CRSwNP and CRSsNP ( p = 0.093). No association was found in factors related to CRS, which included asthma, atopy, allergy, aspirin sensitivity, and family history of nasal polyp ( p value of 0.382, 0.382, 0.144, >0.95, and 0.254, respectively). Conclusion This study indicates an association of IL-1B (−511C, −511T) polymorphism with CRSwNP and CRSsNP in our population, hence there is a possibility of IL-1B involvement in modulating pathogenesis of CRS. There was no significant association of IL-1A (+4845G, +4845T) polymorphism with CRSwNP and CRSsNP, and other factors related.

Inflammatory markers in the nasal mucosa and polyp-modified tissues in chronic rhinosinusitis with nasal polyps

“…Интерлейкин 1β (IL 1β) является классическим медиатором воспаления, считается физиологическим индуктором интерферона γ, вырабатывается в большей степени мононуклеарными фагоцитами, и небольшое количество его синтезируют эндотелиоциты и фибробласты. IL 1β обладает широким спектром воспалительных, физиологических, иммунологических и других свойств и играет важную роль в патогенезе полипозных изменений СО [15].…”

“…Уменьшение его актив ности в стенках кровеносных сосудов и нарастание NK1 в клеточных элементах лимфоидных инфильтратов, покровного и железистого эпителия можно рассматривать как предпосылки к развитию пролиферативного процесса и активации сигнальных каскадов, поступающих через мембрану клеток однослойного многорядного мерцательного эпителия. Индуцируемое нейрокининами увеличение секреции в железах, повышение сосудистой проницаемости, экстравазация плазмы крови и развитие нейрогенного воспаления могут способствовать прогрессированию отечных и воспалительных изменений в СО полости носа [11,13,15].…”

Frequency Analysis Results Distribution of C589t Rs2243250 Polymorphism in Il4 Gene Among Patients with Chronic Rhinosinusitis

“…The stability of CRSwNP incidence rates, regardless of regional characteristics or other external factors, is considered by leading otolaryngologists to be the basis for a more detailed study of the causes of this nosology [4], fi rst of all -genetic predisposition to CRSwNP development. It has been proven that the risk of CRSwNP in the presence of polyposis heredity is 25 times higher, with a heterozygous carriage of the MZ phenotype (defi ciency of alpha-1 antitrypsinase) -4 times, with a dry type of earwax -3 times [5,6]; revealed changes in the karyotypes of peripheral blood cells in patients with CRSwNP [7]. Since chromosomal polymorphism can determine individual sensitivity to the occurrence of any disease, i.e.…”

Actions needed for “Allergy in Asia-Pacific”

“…Based on this notion, Prof. Ruby Pawankar, president of Asia Pacific Association of Allergy, Asthma and Clinical Immunology (APAAACI), has initiated several committees in APAAACI, and enrolled key experts in Asia-Pacific regions as well as the help from international leaders in allergy disorders to work together in the survey and tackle on various aspects of allergy in Asia-Pacific regions [4]. In this issue of Asia Pacific Allergy journal, several important issues of allergy research, such as quality of life of childhood eczema [5], diagnosis of pistachio and peanut allergy [67], allergic rhinitis and asthma survey [8], and genetic study in chronic rhino sinusitis [9] were conducted and reported from Hong Kong, Singapore, Thailand, and Malaysia, respectively. An important review of immune cells in eosinophil esophagitis [10], and educational and teaching material on severe cutaneous adverse drug reactions [11] were reported by allergy researchers from China, Vietnam and Australia.…”