A Study of Serum Uric Acid Levels in Type 2 Diabetes Mellitus Subjects: A Cross Sectional Study

Abstract

Introduction: Diabetes mellitus is one of the major noncommunicable diseases of which world is experiencing a serious epidemic these recent years. Uric acid serves as an early indicator of renal complications in diabetes mellitus patients. Material and methods:This was an Observational, descriptive cross sectional study which was conducted during a period of 18 months (October 2016 and March 2018) This study was designed to check the levels of serum uric acid and its relation with creatinine, microalbuminuria, HbA1c, fasting and post prandial blood sugar levels in type 2 Diabetes subjects.Results: Study included a total of 120 cases of type 2 Diabetes mellitus, out of which there were 69 males (57.5%) and 51 females (42.5%), with a mean age of 59.04 ±13.47 years. Mean FBS was 186.10 ±77.53 mg/dl, with majority of the subjects having elevated FBS. Mean PPBS of 274.94 ±108.66 mg/dl and of HbA1c 8.15 ± 1.7 was observed. The uric acid of majority number of our study participant males (65.22%) had level of ≥ 7.4, with a mean of 9.53 ± 4.38. Mean blood urea and serum creatinine levels were 46.91 ± 15.13 and 1.44 ± 0.29 respectively. There was significant association seen between uric acid levels and urine albumin, serum creatinine, twenty four hour urinary albumin, FBS and PPBS levels and HbA1c levels. Conclusion:Present study had about two-third subjects with type 2 Diabetes mellitus with elevated uric acid levels had microalbuminuria and elevated serum creatinine levels.

Study of serum uric acid levels in type 2 diabetes mellitus in tertiary care hospital in south Gujarat

“…22 In the present study, 106 (29.69%) patients were suffering from anaemia and 54 (15.12%) patients with dyslipidemia. 15,17,19,20 The increase in uric acid levels is not associated with age, gender, duration of DM and family history of DM in the present study (p>0.05) which is similar with other study by Datta et al 20 In present study, there is highly significant association seen between HbA1c and uric acid levels (p<0.001). There is significant association seen between FBS and uric acid levels (p=0.0253).…”

“…The male:female ratio of the present study is correlated with the other studies mentioned in table 6 below. Male : Female Ratio Talwar et al 16 1.17:1 Marwah et al 21 1.18:1 Shrishanth et al 17 1.35:1 Grover et al 19 1.38:1 Datta et al 20 2.08:1 Present study 1.90:1…”

“…Prevalence of uric acid Rao et al 15 29.58% Shrishanth et al 17 36.6% Datta et al 20 35.3% Marwah et al 21 47.2% Grover et al 19 64% Present study 37.25%…”

“…Similarly, study done by Sidhu GK et al18, Marwah et al, Talwar et al, and Shrishanth et al states that increased FBS, PPBS and HbA1C levels are statistically significant with raised uric acid levels in diabetic patients (p<0.01). 16,17,21 The major limitation of the study is the cross-sectional nature of the data which may preclude the findings regarding the temporal nature of the relationship between SUA and diabetes. Therefore, even though there were some independent traditional confounders such as age, bodymass index, total cholesterol and triglycerides, but it was difficult to confirm the cause-effect relationship.…”

Correlation between Serum Uric Acid with Type 2 Diabetes Mellitus and its Complications

“…There was a statistically significant link between diabetes duration and blood uric acid level. 120 type 2 diabetics were researched by Akshay Shirsath et al (2019) [17]. Researchers found a significant relationship between serum creatinine and uric acid levels (p <0.001), and they noticed that when the participants' serum creatinine levels were elevated, so were their uric acid levels.…”