A study of serum magnesium, calcium and phosphorus level, and cognition in the elderly population of South India

Basheer, Mohamed; Kumar, K. Mahesh; Sreekumaran, E; Ramakrishna, T.

doi:10.1016/j.ajme.2015.11.001

Cited by 14 publications

(12 citation statements)

References 23 publications

(25 reference statements)

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“…It is consistent with other studies like Vural et al23 , Basheer et al24 .The cut off value of serum Magnesium was set at 2.15 mg/dl. In this study, below cut off value in case group was 64.7% and in control group was 14.7%.…”

supporting

confidence: 87%

Association of Serum Magnesium Concentration with Alzheimer’s Disease

Uddin¹,

Habib

Islam

et al. 2017

Bangla. J. Neuroscience

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Background: Alzheimer’s disease is a neurodegenerative disease. It is the most common cause of dementia in individuals older than 60 years of age. Age is the most important risk factor for Alzheimer’s disease. It is important to identify modifiable risk factors. One such important modifiable risk factor is Magnesium, a trace element. The objective of the study was to see the association of serum Magnesium concentration with Alzheimer’s disease patients. Method: It was a case control study carried out in neurology department of BSMMU, Dhaka. Total 68 patients were enrolled as study population after satisfying inclusion and exclusion criteria. Among them, 34 were grouped as case and rest 34 were control. Serum Magnesium concentration was detected. Result: Serum Magnesium concentration was significantly lower in AD patients than that of control group [2.04±0.19 mg/dl vs 2.36±0.21 mg/dl. Conclusion: The results of our study revealed an expression that the trace element, Magnesium concentration has an association with Alzheimer’s disease. Bangladesh Journal of Neuroscience 2017; Vol. 33 (2): 70-75

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supporting

confidence: 87%

Association of Serum Magnesium Concentration with Alzheimer’s Disease

Uddin¹,

Habib

Islam

et al. 2017

Bangla. J. Neuroscience

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“…In general, these associations are in line with previous studies showing associations between CMR and age‐related neurodegenerative diseases and cognitive decline. For example, higher serum phosphate, an element filtered by the kidney, is associated with increased risk of incident dementia (Li, Xie, Bowe, Xian, & Al‐Aly, 2017), and risk of brain hemorrhage (Yamada et al, 2016), while low serum phosphate level is associated with cerebral β‐amyloid deposition (Park et al, 2017), increased risk of brain infarction in hemodialysis patients (Yamada et al, 2016), and lower composite score in relation to cognitive function (Basheer, Pradeep Kumar, Sreekumaran, & Ramakrishna, 2016).…”

Section: Discussionmentioning

confidence: 99%

Cardiometabolic risk factors associated with brain age and accelerated brain ageing

Beck

Lange

Pedersen

et al. 2021

Human Brain Mapping

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The structure and integrity of the ageing brain is interchangeably linked to physical health, and cardiometabolic risk factors (CMRs) are associated with dementia and other brain disorders. In this mixed cross‐sectional and longitudinal study (interval mean = 19.7 months), including 790 healthy individuals (mean age = 46.7 years, 53% women), we investigated CMRs and health indicators including anthropometric measures, lifestyle factors, and blood biomarkers in relation to brain structure using MRI‐based morphometry and diffusion tensor imaging (DTI). We performed tissue specific brain age prediction using machine learning and performed Bayesian multilevel modeling to assess changes in each CMR over time, their respective association with brain age gap (BAG), and their interaction effects with time and age on the tissue‐specific BAGs. The results showed credible associations between DTI‐based BAG and blood levels of phosphate and mean cell volume (MCV), and between T1‐based BAG and systolic blood pressure, smoking, pulse, and C‐reactive protein (CRP), indicating older‐appearing brains in people with higher cardiometabolic risk (smoking, higher blood pressure and pulse, low‐grade inflammation). Longitudinal evidence supported interactions between both BAGs and waist‐to‐hip ratio (WHR), and between DTI‐based BAG and systolic blood pressure and smoking, indicating accelerated ageing in people with higher cardiometabolic risk (smoking, higher blood pressure, and WHR). The results demonstrate that cardiometabolic risk factors are associated with brain ageing. While randomized controlled trials are needed to establish causality, our results indicate that public health initiatives and treatment strategies targeting modifiable cardiometabolic risk factors may also improve risk trajectories and delay brain ageing.

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“…The results indicated that women with calcium supplements had higher risk of developing dementia than women without calcium supplementation ( Kern et al, 2016 ). A cross sectional study in 337 subjects in India indicated that increased calcium level could increase the cognitive score ( Basheer et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

An Updated Mendelian Randomization Analysis of the Association Between Serum Calcium Levels and the Risk of Alzheimer’s Disease

et al. 2021

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It has been a long time that the relationship between serum calcium levels and Alzheimer’s disease (AD) remains unclear. Until recently, observational studies have evaluated the association between serum calcium levels and the risk of AD, however, reported inconsistent findings. Meanwhile, a Mendelian randomization (MR) study had been conducted to test the causal association between serum calcium levels and AD risk, however, only selected 6 serum calcium SNPs as the instrumental variables. Hence, these findings should be further verified using additional more genetic variants and large-scale genome-wide association study (GWAS) dataset to increase the statistical power. Here, we conduct an updated MR analysis of the causal association between serum calcium levels and the risk of AD using a two-stage design. In discovery stage, we conducted a MR analysis using 14 SNPs from serum calcium GWAS dataset (N = 61,079), and AD GWAS dataset (N = 63,926, 21,982 cases, 41,944 cognitively normal controls). All four MR methods including IVW, weighted median, MR-Egger, and MR-PRESSO showed a reduced trend of AD risk with the increased serum calcium levels. In the replication stage, we performed a MR analysis using 166 SNPs from serum calcium GWAS dataset (N = 305,349), and AD GWAS dataset (N = 63,926, 21,982 cases, 41,944 cognitively normal controls). Only the weighted median indicated that genetically increased serum calcium level was associated with the reduced risk of AD. Hence, additional studies are required to investigate these findings.

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A study of serum magnesium, calcium and phosphorus level, and cognition in the elderly population of South India

Cited by 14 publications

References 23 publications

Association of Serum Magnesium Concentration with Alzheimer’s Disease

Association of Serum Magnesium Concentration with Alzheimer’s Disease

Cardiometabolic risk factors associated with brain age and accelerated brain ageing

An Updated Mendelian Randomization Analysis of the Association Between Serum Calcium Levels and the Risk of Alzheimer’s Disease

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