A study of oligosaccharide variants of alpha-fetoproteins produced by normal fetuses and fetuses with trisomy 21

Yamamoto, Ritsu; Ohkouchi, Toshihiro; Tabata, Kouichi; Ebina, Yasuhiko; Watari, Hidemichi; Kudo, Masataka; Shimizu, Kayoko; Satomura, Shinji; Minakami, Hisanori; Sakuragi, Noriaki

doi:10.1080/j.0001-6349.2005.00815.x

Acta Obstet Gynecol Scand

2005

DOI: 10.1080/j.0001-6349.2005.00815.x

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A study of oligosaccharide variants of alpha-fetoproteins produced by normal fetuses and fetuses with trisomy 21

Ritsu Yamamoto¹,

Toshihiro Ohkouchi²,

Kouichi Tabata³

et al.

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2024

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Role of Alpha-Fetoprotein in the Pathogenesis of Cancer

Chaudhuri,

Samanta,

Dey

et al. 2024

J Environ Pathol Toxicol Oncol

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Alpha-fetoprotein (AFP) belongs to the albuminoid protein family and is considered as the fetal analog of serum albumin. This plasma protein is initially synthesized in the fetal liver and yolk sac and shows a maximum peak near the end of the first trimester. Later, concentrations begin to decline prenatally and drop precipitously after birth. This protein has three key ligand-binding pockets for interactions with various biomolecules. It contains multiple phosphorylation and acetylation sites for the regulation of physiological and pathophysiological states. High serum AFP titer is an established biomarker for yolk sac, embryonal and hepatocellular carcinoma. The present review critically analyzes the chemical nature, receptors, clinical implications, and therapeutic aspects of AFP, underpinning the development of different types of cancer.

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Role of Alpha-Fetoprotein in the Pathogenesis of Cancer

Chaudhuri,

Samanta,

Dey

et al. 2024

J Environ Pathol Toxicol Oncol

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A study of oligosaccharide variants of alpha-fetoproteins produced by normal fetuses and fetuses with trisomy 21

Cited by 1 publication

References 0 publications

Role of Alpha-Fetoprotein in the Pathogenesis of Cancer

Role of Alpha-Fetoprotein in the Pathogenesis of Cancer

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