A study of neurite orientation dispersion and density imaging in wilson's disease

Song, Yukun; Li, Xinbei; Huang, Xiaolong; Zhao, Jing; Zhou, Xiangxue; Wang, Yuliang; Yan, Xu; Wang, Jingyan; Chu, Jianping

doi:10.1002/jmri.25930

Cited by 19 publications

(16 citation statements)

References 28 publications

(30 reference statements)

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“…FA reduction in white matter of the T2DM subjects primarily resulted from the reduced Vic, which indicated a decreased density of neurites (axons and dendrites), and was probably related to the changes in morphological structure, such as decreased dendrite length and dendrite spine loss. The significant Vic reduction in the bilateral thalamus may demonstrate the compromise or loss of neurite and neuronal fiber projections in the gray matter nuclei . The decreased Vic may also reflect neuron degermation and liquefaction within the gray matter, which might be similar to the changes in dendrite structure in Wilson disease and Parkinson disease studies.…”

Section: Discussionmentioning

confidence: 85%

“…The significant Vic reduction in the bilateral thalamus may demonstrate the compromise or loss of neurite and neuronal fiber projections in the gray matter nuclei . The decreased Vic may also reflect neuron degermation and liquefaction within the gray matter, which might be similar to the changes in dendrite structure in Wilson disease and Parkinson disease studies.…”

Section: Discussionmentioning

confidence: 85%

“…These indices have also shown satisfactory correlations with the histological measurements in animal studies . The technique has been widely used in investigations of neurological disorders …”

mentioning

confidence: 75%

“…A novel diffusion magnetic resonance imaging (MRI) technique, termed neurite orientation dispersion and density imaging (NODDI), has been proposed to map the microstructural complexities of neurites . Unlike DTI, NODDI is a multicompartment model that separates the signal from extra‐ and intraaxonal compartments in each voxel, and provides intracellular volume fraction (Vic, which represents the density of neurites including axons and dendrites) and neurite orientation dispersion (ODI, which represents the bending and fanning of axons in white matter and the pattern of sprawling dendrite progression in gray matter) estimates . These indices have also shown satisfactory correlations with the histological measurements in animal studies .…”

mentioning

confidence: 99%

“…17,18 The technique has been widely used in investigations of neurological disorders. 16,[19][20][21][22] Early changes in brain microstructures may contribute to increased dementia risk. Some of the alterations may be investigated by diffusion MRI methods.…”

mentioning

confidence: 99%

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Application of neurite orientation dispersion and density imaging to characterize brain microstructural abnormalities in type‐2 diabetics with mild cognitive impairment

Xiong

Zhang

Shi

et al. 2019

Magnetic Resonance Imaging

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Background Diffusion‐tensor‐imaging (DTI) is sensitive in detecting white matter changes in type‐2 diabetes mellitus (T2DM). However, DTI indices can be affected by either neurite density or spatial variation. A novel diffusion MRI technique, termed neurite orientation dispersion and density imaging (NODDI), can provide distinct indices of fiber density and dispersion. Purpose To characterize brain microstructural alterations in T2DM patients with mild cognitive impairment (MCI) using the NODDI model. Study Type Cross‐sectional. Subjects Twenty T2DM patients with (DM‐MCI group), 18 age‐ and gender‐matched T2DM patients with normal cognition (DM‐NC group), and 28 euglycemic healthy controls (HC). Field Strength/Sequence 3T/NODDI. Assessment Diffusion data were analyzed using tract‐based‐spatial‐statistics (TBSS) analysis in white matter and voxel‐based analysis in both white and gray matter. NODDI indices, including intracellular volume fraction (Vic) and orientation dispersion index (ODI), were estimated from multiple regions and compared among these groups. Statistical Tests Differences between groups were compared by Student's t‐test, Pearson chi‐square test, or analysis of variance when appropriate. Correlation analyses were performed to investigate the relationship between NODDI variables and clinical measurements. Results Whole‐brain TBSS revealed that 2.29% and 2.02% of the white matter regions exhibited decreased fractional anisotropy and Vic, respectively, between the DM‐NC and HC, while considerably larger white matter areas showed decreased fractional anisotropy (38.38%) and Vic (34.64%) between the DM‐MCI and HC (Student's t‐test, P < 0.05). However, the angular variation of neurites, characterized by ODI, exhibited very little (0.1%, P < 0.05) or no difference (P > 0.05) between either the DM‐MCI or DM‐NC groups and HC. Decreased Vic values in the genu of the corpus callosum (R = 0.580, 0.551 and 0.586, P < 0.01) and thalamus (R = 0.570, 0.616, and 0.595, P < 0.05) correlated with glycosylated hemoglobin A1c level, disease duration, and neuropsychological scores, respectively. Data Conclusion T2DM patients with cognitive decline had reduced Vic, which indicated decreased density of axons and dendrites. NODDI might be able to help probe microstructural changes in white and gray matter and provide information on diabetic encephalopathy, including those with cognitive impairment. Level of Evidence: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:889–898.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 85%

mentioning

confidence: 75%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Application of neurite orientation dispersion and density imaging to characterize brain microstructural abnormalities in type‐2 diabetics with mild cognitive impairment

Xiong

Zhang

Shi

et al. 2019

Magnetic Resonance Imaging

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Microstructural Anomalies Evaluated by Neurite Orientation Dispersion and Density Imaging Are Related to Deficits in Facial Emotional Recognition via Perceptual‐Binding Difficulties in Autism Spectrum Disorder

et al. 2020

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The integration of visual features is important for recognizing objects as a coherent whole, a key domain of difficulty in autism spectrum disorder (ASD). We tested the hypothesis that ASD patients exhibit difficulties in facial emotional recognition via perceptual binding difficulties due to weak coherence. We assessed 18 ASD and 27 typically developing individuals for their ability to identify emotional expressions from faces in pictures moving behind a narrow vertical and horizontal slit. In this task, only a single local piece of facial information was provided at any one time through the slit. Using a voxel-based analysis of neurite-orientation dispersion and density imaging (NODDI), we examined the relationship between NODDI index values at each voxel and the behavioral performance of ASD patients in the slit-viewing paradigm. ASD patients demonstrated impaired recognition of facial emotional expression only in horizontal slit-viewing. This deficit was associated with deficits in communication ability. Voxel-based analysis revealed significant negative correlations between behavioral deficits in horizontal slit-viewing and NODDI index values in clusters including the ventral occipital complex region, superior temporal/parietal association areas, and forceps major of the corpus callosum. Our results indicated deficits for the first time in perceptual integration of facial expression across hemispheres in ASD patients due to microstructural disturbances in the corpus callosum and areas related to viewing of the human face. This may underscore the difficulties faced by ASD patients in understanding the emotions of other people, contributing to impairments in communication ability in ASD patients.

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Neurite Orientation Dispersion and Density Imaging of Rat Brain Microstructural Changes due to Middle Cerebral Artery Occlusion at a 3T MRI

et al. 2021

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A study of neurite orientation dispersion and density imaging in wilson's disease

Abstract: 2 Technical Efficacy Stage 2 J. MAGN. RESON. IMAGING 2018;48:423-430.

Cited by 19 publications

References 28 publications

Application of neurite orientation dispersion and density imaging to characterize brain microstructural abnormalities in type‐2 diabetics with mild cognitive impairment

Application of neurite orientation dispersion and density imaging to characterize brain microstructural abnormalities in type‐2 diabetics with mild cognitive impairment

Microstructural Anomalies Evaluated by Neurite Orientation Dispersion and Density Imaging Are Related to Deficits in Facial Emotional Recognition via Perceptual‐Binding Difficulties in Autism Spectrum Disorder

Neurite Orientation Dispersion and Density Imaging of Rat Brain Microstructural Changes due to Middle Cerebral Artery Occlusion at a 3T MRI

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