A study of MRI changes in Wilson disease and its correlation with clinical features and outcome

A study of neurite orientation dispersion and density imaging in wilson's disease

“…Additionally, reduction of the Vic in the putamen of WD patients was more prominent than other regions, which may reflect that the putamen is the most severely involved nucleus. The Vic and ODI showed no statistical difference between the right and left BG and thalamus, which indicates that disease onset in WD is bilaterally symmetrical, and these findings are consistent with previous reports …”

Pontomesencephalic Atrophy and Postural Instability in Wilson Disease

“…Conventional MR imaging did not reveal any signal changes in PSP, multisystem atrophy, and PD; whereas in WD, midbrain involvement occurred in 32.4%-49% of patients. 4,8,23 The involvement of the pons, cerebellum, and cerebellar peduncles, however, is rare in WD. The signal changes in the midbrain and pons in our patients, however, were not related to the midbrain and pons areas, respectively.…”

“…[3][4][5] The characteristic cranial MR imaging abnormalities in WD are corpus striatal involvement and the "giant Panda sign," which are reported in 14.3%-71.5% of patients. [6][7][8] Involvement of the pons and midbrain may lead to an abnormal postural reflex in WD, which may increase the neurologic disability. Recently, the MR Parkinsonism index (MRPI) has been reported to correctly differentiate progressive supranuclear palsy (PSP) from Parkinson disease (PD) and multisystem atrophy.…”

“…In neurologic WD, involvement of the midbrain and pons on MR imaging has been reported in up to 66% of patients. 4,8 There is no study evaluating postural reflex and MRPI in patients with neurologic WD, to our knowledge. In this communication, we report MRPI parameters in patients with neurologic WD and correlate these with postural reflex and disease severity.…”

Wilson Hastalarinda Ilk Basvuruda Norolojik Bulgular

“…Bu genetik defekt sonrası safranın ekskresyonu azalır ve bakır karaciğer, böbrek, kornea, beyin ve diğer organlarda birikir. Nörolojik bulgular genellikle ikinci dekatta belirginleşir (2)(3)(4). Prognoz genellikle karaciğer tutulumunun şiddetine ve nörolojik tutuluma bağlıdır.…”