A Study of Moderately Differentiated Neuroendocrine Carcinomas of the Larynx and an Examination of Non‐Neoplastic Larynx Tissue for Neuroendocrine Cells

Chung, Jin-Haeng; Lee, Seung-Sook; Shim, Yoon-Sang; Kim, Sang Yoon; Nam, Soon-Yuhl; Kim, Dong-Hoon; Cho, Kyung–Ja

doi:10.1097/00005537-200407000-00023

Cited by 38 publications

(47 citation statements)

References 26 publications

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“…Six of these are newly reported: four from Barnes-Jewish Hospital, one from Montefiore/Albert Einstein Medical College, and one from University of Pittsburgh Medical Center. The remainder were identified from the existing literature [8][9][10].…”

Section: Resultsmentioning

confidence: 99%

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Large Cell Neuroendocrine Carcinoma of the Larynx: Definition of an Entity

Lewis

Spence

Chiosea

et al. 2010

Head and Neck Pathol

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Laryngeal atypical carcinoids (AC/moderatelydifferentiated neuroendocrine carcinoma) are associated with moderately aggressive clinical behavior; however, a subset of tumors classified as AC have much greater aggressive potential. These tumors fulfill the proposed diagnostic criteria for pulmonary large cell neuroendocrine carcinoma, albeit in the larynx. In the current WHO classification, laryngeal large cell neuroendocrine carcinomas (LCNEC) are classified as variants of AC, whereas pulmonary LCNEC are classified as poorly-differentiated neuroendocrine carcinomas. Reported outcomes for pulmonary tumors support the separate classification of LCNEC. Five and ten year survival rates for pulmonary AC are 61-73, and 35-59%, respectively, while the 5-year survival rate for pulmonary LCNEC is as low as 30%. By extension, we postulate that the biologic potential of laryngeal LCNEC is similar to that of small-cell carcinoma (poorly-differentiated neuroendocrine carcinoma), and as such, warrants reclassification. The files of Barnes Jewish Hospital/Washington University were searched for the term ''neuroendocrine'' and the anatomic subsite larynx. Neuroendocrine carcinoma cases were evaluated using the WHO definitions for pulmonary AC and LCNEC; small cell carcinoma was excluded. Cases were also solicited from the larger head and neck pathology community. A literature search was also performed for cases of laryngeal neuroendocrine carcinoma, and cases which could be clearly classified as LCNEC by this scheme were captured as well. Six new cases plus four reported cases were identified which fulfill the WHO criteria for pulmonary LCNEC (eight men and two women). Nine patients presented at stage IV and 88% died of disease (DOD), 75 and 100% of these at 2 and 3 years, respectively. Laryngeal LCNEC is a rare entity, distinct from AC. We recommend that laryngeal tumors fulfilling WHO criteria for pulmonary LCNEC not be classified as variants of AC, but as variants of small cell carcinoma (poorly-differentiated neuroendocrine carcinoma) as they are associated with poorer outcome.

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Section: Resultsmentioning

confidence: 99%

“…Case 8 (Previously Published) [9] This 67-year-old man presented with a 1 month history of hoarseness. Past medical history was significant for a 45 pack year history of smoking.…”

Section: Outcomementioning

confidence: 99%

Large Cell Neuroendocrine Carcinoma of the Larynx: Definition of an Entity

Lewis

Spence

Chiosea

et al. 2010

Head and Neck Pathol

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“…The visceral locations were stable according to regular CT assessment, but the patient died one year after the discovery of the intraoral lesion. [4], [5], [6], [7], [8], [9] larynx primary 16 salivary glands [10], [11], [12], [13] parotid gland primary 5 [14] submandibular gland primary 1…”

Section: Discussionmentioning

confidence: 99%

Rare oral metastasis from a probable large-cell neuroendocrine carcinoma of the lung

Souron

Weingertner

Seigle-Murandi

et al. 2016

Med Buccale Chir Buccale

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-Introduction:The prevalence of neuroendocrine tumors is 1/100 000 worldwide. Lung locations account for 25% and the oral cavity is very rarely involved. Observation: We reported the case of gingival hyperplasia around an upper molar in a patient with a medical history of lung adenocarcinoma treated by targeted chemotherapy. Incisional biopsy of the intraoral lesion revealed a large-cell neuroendocrine carcinoma (LCNEC). New imaging assessment revealed multiple metastasis locations of the lung disease. This case made us question the link between gingival LCNEC and the lung adenocarcinoma diagnosed through pleural cytology. Review of cytology findings did not make it possible to identify a neuroendocrine component among adenocarcinoma cells. Immunohistochemical tools sometimes help to differentiate primary from secondary lesions, but this was inconclusive here. Discussion: The literature shows that in cases of lung composite carcinoma, one component may be absent on small histology samples, and therefore on cytology. It was not possible either to rule out neuroendocrine carcinoma development under the effect of targeted chemotherapy. We considered the diagnosis of intraoral metastasis of a composite lung carcinoma which metastasized to its neuroendocrine component in the oral cavity. Conclusion: To our knowledge, this is the first case of LCNEC gingival hyperplasia revealing metastatic progression of lung adenocarcinoma.Résumé -Rare métastase buccale d'un probable carcinome neuroendocrine pulmonaire à grandes cellules. Introduction : La prévalence des tumeurs neurodendocrines est de 1/100 000 à travers le monde parmi lesquelles 25 % sont de localisation pulmonaire. Mais la localisation buccale est extrêmement rare. Observation : Il s'agissait d'une lésion gingivale hyperplasique autour d'une molaire maxillaire chez un patient présentant un antécédent d'adénocarcinome pulmonaire suivi et traité par chimiothérapie ciblée.L'analyse anatomopathologique de la lésion intra-orale montrait un carcinome neuroendocrine à large cellules (LCNEC). Un bilan d'imagerie révélait de multiples métastases de la tumeur pulmonaire. Ce cas nous interpelle sur le lien entre un LCNEC gingival et l'adénocarcinome pulmonaire diagnostiqué initialement à partir d'une cytologie pleurale. Le nouvel examen de cette cytologie n'a pas permis d'identifier une composante neuroendocrine parmi les cellules prélevées.

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“…Before the widespread use of immunohistochemical studies, these tumors were probably grouped with the undiVerentiated/poorly diVerentiated carcinomas of the larynx. Once it became apparent that these tumorsmarked by light microscopy by a population of cells which were larger, with more abundant cytoplasm, than small cell carcinoma cells-expressed neuroendocrine markers, they were segregated from the remainder of the poorly diVerentiated carcinomas as large cell neuroendocrine carcinomas [10][11][12][13]. These are principally tumors of older men, with a dismal prognosis.…”

Section: Laryngeal Large Cell Neuroendocrine Carcinomasmentioning

confidence: 99%