A Study Of Micturition Inducing Sites In The Periaqueductal Gray Of The Mesencephalon

Taniguchi, Narumi; Miyata, Masanobu; Yachiku, Sunao; Kaneko, Shigeo; Yamaguchi, Satoshi; Numata, Atsushi

doi:10.1097/00005392-200210010-00096

Cited by 13 publications

(28 citation statements)

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“…Blood pressure increase was previously observed by electrical stimulation of the PMC and micturition-inducing sites in the PAG (20). Weak-intensity electrical stimulation of the PMC elicited predominantly bladder contraction rather than blood pressure increase, while weak-intensity electrical stimulation of micturition-inducing sites in the PAG caused opposite response (20). Thus similar but different reactions of the bladder and blood pressure were observed during electrical stimulation of the PMC and PAG.…”

Section: Discussionmentioning

confidence: 64%

“…Therefore, it seems that the function of the micturition-suppressing region in the PAG is independent of the pontine urine storage center. Compared with the micturition-inducing sites in the PAG (20), micturition-suppressing sites in the PAG were located more dorsal and rostral. In the present study, we could not induce bladder contractions by electrical stimulation of the rostral PAG.…”

Section: Discussionmentioning

confidence: 78%

“…Respiratory changes were also elicited by electrical stimulation. Blood pressure increase was previously observed by electrical stimulation of the PMC and micturition-inducing sites in the PAG (20). Weak-intensity electrical stimulation of the PMC elicited predominantly bladder contraction rather than blood pressure increase, while weak-intensity electrical stimulation of micturition-inducing sites in the PAG caused opposite response (20).…”

Section: Discussionmentioning

confidence: 88%

“…Blok and Holstege (5) reported direct projections from the PAG to the PMC. Taniguchi et al (20) and Matsuura et al (15) reported micturition-inducing sites in the PAG. In the latter two reports, micturition-inducing sites in the PAG were located at the ventrolateral portion of the caudal PAG.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the pontine tegmentum is critical for micturition and urine storage. Recent studies in cats and rats found that electrical and chemical stimulation of the ventrolateral periaqueductal gray (PAG) induced micturition (15,20). These results implicate an important role of the mesencephalon in the micturition reflex.…”

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confidence: 99%

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Micturition-suppressing region in the periaqueductal gray of the mesencephalon of the cat

Numata¹,

Iwata²,

Iuchi³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

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The periaqueductal gray (PAG) of the mesencephalon has been implicated to be involved in the control of micturition. We investigated the micturition-suppressing region in the PAG of the cat. Decerebrated 27 adult cats were used. A microelectrode was inserted stereotaxically into the PAG, and a region was searched where electrical stimulation suppressed isovolumetric bladder contractions. Simultaneous stimulation of the pontine micturition center (PMC) and micturition-suppressing region in the PAG was performed before and after an injection of bicuculline (GABA(A) blocker) into the PMC. The micturition-suppressing region was found at the dorsolateral margin of the rostral PAG. Bladder contractions were not provoked by simultaneous stimulation of the PMC and micturition-suppressing region in the PAG. However, after bicuculline injection into the PMC, partial bladder contractions were provoked by simultaneous stimulation of the PMC and the micturition-suppressing region in the PAG. These results suggest that the dorsolateral margin of the rostral PAG includes the micturition-suppressing region that seems to have neural connections with the PMC. GABA is assumed to be one of the neurotransmitters that are involved in the PMC inhibition from the micturition-suppressing region in the PAG.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Micturition-suppressing region in the periaqueductal gray of the mesencephalon of the cat

Numata¹,

Iwata²,

Iuchi³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

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Neural Control of the Lower Urinary Tract

Groat

Griffiths

Yoshimura

2014

Comprehensive Physiology

352

527

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This article summarizes anatomical, neurophysiological, pharmacological, and brain imaging studies in humans and animals that have provided insights into the neural circuitry and neurotransmitter mechanisms controlling the lower urinary tract. The functions of the lower urinary tract to store and periodically eliminate urine are regulated by a complex neural control system in the brain, spinal cord, and peripheral autonomic ganglia that coordinates the activity of smooth and striated muscles of the bladder and urethral outlet. The neural control of micturition is organized as a hierarchical system in which spinal storage mechanisms are in turn regulated by circuitry in the rostral brain stem that initiates reflex voiding. Input from the forebrain triggers voluntary voiding by modulating the brain stem circuitry. Many neural circuits controlling the lower urinary tract exhibit switch-like patterns of activity that turn on and off in an all-or-none manner. The major component of the micturition switching circuit is a spinobulbospinal parasympathetic reflex pathway that has essential connections in the periaqueductal gray and pontine micturition center. A computer model of this circuit that mimics the switching functions of the bladder and urethra at the onset of micturition is described. Micturition occurs involuntarily in infants and young children until the age of 3 to 5 years, after which it is regulated voluntarily. Diseases or injuries of the nervous system in adults can cause the re-emergence of involuntary micturition, leading to urinary incontinence. Neuroplasticity underlying these developmental and pathological changes in voiding function is discussed.

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The Role of the Periaqueductal Gray Matter in Lower Urinary Tract Function

et al. 2018

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The periaqueductal gray matter (PAG), as one of the mostly preserved evolutionary components of the brain, is an axial structure modulating various important functions of the organism, including autonomic, behavioral, pain, and micturition control. It has a critical role in urinary bladder physiology, with respect to storage and voiding of urine. The PAG has a columnar composition and has extensive connections with its cranially and caudally located components of the central nervous system (CNS). The PAG serves as the control tower of the detrusor and sphincter contractions. It serves as a bridge between the evolutionary higher decision-making brain centers and the lower centers responsible for reflexive micturition. Glutamatergic cells are the main operational neurons in the vlPAG, responsible for the reception and relay of the signals emerging from the bladder, to related brain centers. Functional imaging studies made it possible to clarify the activity of the PAG in voiding and filling phases of micturition, and its connections with various brain centers in living humans. The PAG may be affected in a wide spectrum of disorders, including multiple sclerosis (MS), migraine, stroke, Wernicke's encephalopathy, and idiopathic normal pressure hydrocephalus, all of which may have voiding dysfunction or incontinence, in certain stages of the disease. This emphasizes the importance of this structure for the basic understanding of voiding and storage disorders and makes it a potential candidate for diagnostic and therapeutic interventions.

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A Study Of Micturition Inducing Sites In The Periaqueductal Gray Of The Mesencephalon

Abstract: Nerve cells on the ventrolateral side of the periaqueductal gray have neural communications with the pontine micturition center bilaterally and they regulate micturition.

Cited by 13 publications

References 13 publications

Micturition-suppressing region in the periaqueductal gray of the mesencephalon of the cat

Micturition-suppressing region in the periaqueductal gray of the mesencephalon of the cat

Neural Control of the Lower Urinary Tract

The Role of the Periaqueductal Gray Matter in Lower Urinary Tract Function

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