Micturition-suppressing region in the periaqueductal gray of the mesencephalon of the cat

Numata, Atsushi; Iwata, Tatsuya; Iuchi, Hiromichi; Taniguchi, Narumi; Kita, Masafumi; Wada, Naoki; Kato, Yukio; Κakizaki, Hidehiro

doi:10.1152/ajpregu.00393.2006

Cited by 21 publications

(17 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…, Numata et al . ). However, the present study is important because it reveals further information on the mechanisms that may underlie these actions.…”

Section: Discussionmentioning

confidence: 97%

Effect of electrical vs. chemical deep brain stimulation at midbrain sites on micturition in anaesthetized rats

2015

View full text Add to dashboard Cite

Electrical deep brain stimulation within the midbrain can inhibit reflex micturition. We suggest that the applied stimulus entrained activity in the neural circuitry locally, thereby imposing an unphysiological pattern of activity. In a way similar to the use of electrical signals to 'jam' radio transmission, this may prevent a synchronized pattern of efferent activity being transmitted to the spinal outflows to orchestrate a coordinated voiding response. Further experiments to record neuronal firing in the midbrain during the deep brain stimulation will be necessary to test this hypothesis.

show abstract

“…, Numata et al . ). However, the present study is important because it reveals further information on the mechanisms that may underlie these actions.…”

Section: Discussionmentioning

confidence: 97%

Effect of electrical vs. chemical deep brain stimulation at midbrain sites on micturition in anaesthetized rats

2015

View full text Add to dashboard Cite

show abstract

“…This finding raised the possibility that a mesencephalic bladder inhibitory center tonically controlled micturition. An inhibitory region seems to be located in the dorsolateral margin of the rostral PAG (482) because chemical or electrical stimulation at this site inhibits reflex bladder contractions and the contractions induced by electrical stiumulation of the PMC. Injection of bicuculline, a GABA A receptor antagonist, into the PMC blocks the PAG induced inhibition of PMC stimulation indicating that GABA is the transmitter in the inhibitory pathway (482).…”

Section: Voiding Mechanismsmentioning

confidence: 99%

Neural Control of the Lower Urinary Tract

Groat

Griffiths

Yoshimura

2014

Comprehensive Physiology

348

527

View full text Add to dashboard Cite

This article summarizes anatomical, neurophysiological, pharmacological, and brain imaging studies in humans and animals that have provided insights into the neural circuitry and neurotransmitter mechanisms controlling the lower urinary tract. The functions of the lower urinary tract to store and periodically eliminate urine are regulated by a complex neural control system in the brain, spinal cord, and peripheral autonomic ganglia that coordinates the activity of smooth and striated muscles of the bladder and urethral outlet. The neural control of micturition is organized as a hierarchical system in which spinal storage mechanisms are in turn regulated by circuitry in the rostral brain stem that initiates reflex voiding. Input from the forebrain triggers voluntary voiding by modulating the brain stem circuitry. Many neural circuits controlling the lower urinary tract exhibit switch-like patterns of activity that turn on and off in an all-or-none manner. The major component of the micturition switching circuit is a spinobulbospinal parasympathetic reflex pathway that has essential connections in the periaqueductal gray and pontine micturition center. A computer model of this circuit that mimics the switching functions of the bladder and urethra at the onset of micturition is described. Micturition occurs involuntarily in infants and young children until the age of 3 to 5 years, after which it is regulated voluntarily. Diseases or injuries of the nervous system in adults can cause the re-emergence of involuntary micturition, leading to urinary incontinence. Neuroplasticity underlying these developmental and pathological changes in voiding function is discussed.

show abstract

“…This finding raised the possibility that a mesencephalic bladder inhibitory centre tonically controlled micturition. The inhibitory region seems to be located in the dorsolateral margin of the rostral PAG (Numata et al 2008) because chemical or electrical stimulation at this site inhibits reflex bladder contractions and the contractions induced by electrical stimulation of the PMC. Injection of bicuculline a GABA A receptor antagonist into the PMC blocks the PAG-induced inhibition of PMC stimulation indicating that GABA is the transmitter in the inhibitory pathway (Numata et al 2008).…”

Section: Voiding Mechanismsmentioning

confidence: 99%

Organization of the neural switching circuitry underlying reflex micturition

2012

View full text Add to dashboard Cite

The functions of the lower urinary tract to store and periodically eliminate urine are regulated by a complex neural control system in the brain and spinal cord that coordinates the activity of the bladder and urethral outlet. Experimental studies in animals indicate that urine storage is modulated by reflex mechanisms in the spinal cord, whereas voiding is mediated by a spinobulbospinal pathway passing through a coordination centre in the rostral brain stem. Many of the neural circuits controlling micturition exhibit switch-like patterns of activity that turn on and off in an all-or-none manner. This study summarizes the anatomy and physiology of the spinal and supraspinal micturition switching circuitry and describes a computer model of these circuits that mimics the switching functions of the bladder and urethra at the onset of micturition.

show abstract

Micturition-suppressing region in the periaqueductal gray of the mesencephalon of the cat

Cited by 21 publications

References 25 publications

Effect of electrical vs. chemical deep brain stimulation at midbrain sites on micturition in anaesthetized rats

Effect of electrical vs. chemical deep brain stimulation at midbrain sites on micturition in anaesthetized rats

Neural Control of the Lower Urinary Tract

Organization of the neural switching circuitry underlying reflex micturition

Contact Info

Product

Resources

About