A Study of Liver Disorder in Ulcerative Colitis

Brooke, Bryan N.; Dykes, P. W.; Walker, Frank C.

doi:10.1136/pgmj.37.427.245

Cited by 54 publications

(14 citation statements)

References 6 publications

(6 reference statements)

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“…Recurrent portal infection could lead to chronic biliary tract infection, infl ammation, and subsequent fibrosis and classical stricture formation [58]. One study even found that portal bacteremia was present in patients who had colonic surgery [59]. Subsequent studies, however, could not confirm the findings of portal vein phlebitis [31,58].…”

Section: Etiologymentioning

confidence: 84%

Primary Sclerosing Cholangitis

Enns¹

2006

Diseases of the Gallbladder and Bile Ducts

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Section: Etiologymentioning

confidence: 84%

Primary Sclerosing Cholangitis

Enns¹

2006

Diseases of the Gallbladder and Bile Ducts

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“…With the finding of bacteria in the portal blood of a number of patients with ulcerative colitis (Brooke and Slaney, 1958;Brooke, Dykes, and Walker, 1961), it was suggested that portal bacteraemia might be the aetiological factor responsible for the pathology in the hepatobiliary system and the finding of an improvement in hepatic function after colectomy in some patients (Stauffer, Sauer, Dearing, and Baggenstoss, 1965;Warren, Athanassiades, and Monge, 1966) seemed to support this. However, the improvement is by no means invariable.…”

Section: Discussionmentioning

confidence: 99%

Ulcerative colitis and carcinoma of the proximal bile ducts

Ross¹,

Braasch²

1973

Gut

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SUMMARY In a review of 103 patients with carcinoma of the proximal bile ducts, eight patients were noted to have had ulcerative colitis also. This finding is strongly suggestive of a specific association between the two diseases. In three of the patients, carcinoma developed several years after proctocolectomy. Seven of the eight patients were significantly younger than the median age of the group as a whole, but no other apparent difference was noted between those with ulcerative colitis and the remainder of the group.During a review of the records of 103 patients with carcinoma of the proximal bile ducts seen at the Lahey Clinic Foundation during a 15-year period (Ross, Braasch, and Warren, 1972), it was noted that eight of these patients had, at some time, also had ulcerative colitis. Parker and Kendall (1954) were the first to record this association but, more recently, a number ofauthors have suggested that carcinoma of the biliary tract may be a rare complication of chronic ulcerative colitis (Rankin, Skyring, and Goulston, 1966;Converse, Reagan, and DeCosse, 1971;Morowitz, Glagov, Dordal, and Kirsener, 1971 occurred only four months after the onset of jaundice. At necropsy the patient was found to have a moderately well differentiated adenocarcinoma involving all the proximal bile ducts with direct spread into the liver. Metastases were discovered in the lymph nodes and in the porta hepatis. The presence of ascites and biliary cirrhosis was also recorded. CASE 2A 23-year-old woman first had symptoms of ulcerative colitis that were partially controlled during the next 20 years with unspecified medical treatment. However, at the age of 43, the patient underwent an emergency operation for a perforation of the colon, and a colostomy was constructed. Two years later, another perforation of the colon developed and this time an ileostomy with subtotal colectomy was carried out, leaving the rectum in place.At the age of46, gastrointestinal symptoms without jaundice developed that led to the performance of a laparotomy. A tumour, 3 cm, was found at the junction of the common hepatic and cystic ducts, and a biopsy showed it to be a poorly differentiated adenocarcinoma. The patient was referred to the Lahey Clinic where the presence of arthritis and a whitish discharge from the rectal stump were noted.

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“…The frequency of fatty infiltration was stressed by Pollard & Block (1948) and Warren & Sommers (1949) on autopsy material and in operative biopsies by Bacon (1958) and Brooke, Dykes & Walker (1961) which they felt reflected the severity of the illness. Pericholangitis is less common but more specifically related to the colitis.…”

Section: Liver Diseasementioning

confidence: 99%

“…Pericholangitis is less common but more specifically related to the colitis. Infection spreads to the liver via the portal vein and it may be possible to culture coliform organisms from the portal vein or liver substance (Brooke et al, 1961 ;Rankin et al, 1959). The condition is often symptomless and recognized by abnormal serological tests suggesting an obstructive jaundice.…”

Section: Liver Diseasementioning

confidence: 99%

The systemic complications of ulcerative colitis

Watkinson

1968

Postgraduate Medical Journal

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Summary A brief review of some of the systemic lesions of ulcerative colitis has been made. In 465 patients seen between 1948 and 1963 in Leeds, skin lesions occurred in 6·2%, colitic arthritis in 12·0%, sacro-iliitis in 18% and spondylitis in 6%. Eye lesions developed in 4% and liver disease in 2%. The significance of some of these lesions has been reviewed.

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A Study of Liver Disorder in Ulcerative Colitis

Cited by 54 publications

References 6 publications

Primary Sclerosing Cholangitis

Primary Sclerosing Cholangitis

Ulcerative colitis and carcinoma of the proximal bile ducts

The systemic complications of ulcerative colitis

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