A Study of Lipid Peroxidation and Vitamin E in Dairy Cows with Hepatic Insufficiency

Mudroň, Pavol; Rehage, J.; K, Qualmann; Hp, Sallmann; Scholz, H

doi:10.1046/j.1439-0442.1999.00206.x

Cited by 52 publications

(56 citation statements)

References 15 publications

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“…In early lactation period, non-esterified fat acids (NEFA), which form as the result of lipid mobilization, are used to meet energy need 27,28 . It has been stated that free radical level will also be higher because of NEFA oxidation that increases in hepatocyte mitochondrium 29 . A decrease in the antioxidant capacity may be possible depending on the function of secretion and synthesis in the liver of ruminant in which hepatomegaly is seen due to elevated intracellular lipid rate resulting from increased NEFA synthesis 30,31 .…”

Section: Discussionmentioning

confidence: 99%

Erken ve Geç Laktasyon Periyodunun Keçilerde Plazma Oksidan/Antioksidan Dengesi Üzerindeki Etkileri

Karapehlivan¹,

Kaya²,

Sağ³

et al. 2013

Kafkas Univ Vet Fak Derg

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SummaryThe purpose of the study was to investigate effects on oxidant and antioxidant balance of early and late lactation period in goats. Blood samples used in study were obtained from Halep goats in early and late lactation period. Oxidative stress index (OSI) and lipid hydroperoxide (LOOH) and total oxidative status (TOS) and total antioxidant status (TAS) were analyzed to determined of oxidant and antioxidant balance. Plasma TOS, OSI and LOOH levels in early lactation period were significantly higher (P<0.001) than late lactation period of goats, while lower (P<0.001) level of TAS. It was concluded that lipid peroxidation decreased and antioxidant defence system mechanism in late lactation period in goats served as more positive than early lactation period. Keywords: Goat, Lactation, Total antioxidant status, Total oxidant status, Oxidative stress Erken ve Geç Laktasyon Periyodunun Keçilerde Plazma Oksidan/Antioksidan Dengesi Üzerindeki Etkileri ÖzetBu çalışmada keçilerin oksidan ve antioksidan dengesi üzerinde erken ve geç laktasyon periyodunun etkilerinin araştırılması amaçlandı. Çalışmada kullanılan kan örnekleri erken ve geç laktasyon periyodunda bulunan Halep keçilerinden elde edildi. Oksidan ve antioksidan dengenin değerlendirilmesi için oksidatif stres indeksi (OSİ), lipid hidroperoksid (LOOH), total oksidan (TOS) ve total antioksidan düzeyleri (TAS) analiz edildi. Erken laktasyon periyodunda plazma TOS, OSİ ve LOOH düzeylerinin geç laktasyon periyodundaki keçilere göre daha yüksek (P<0.001) olduğu belirlenirken, TAS düzeyinin daha düşük olduğu belirlendi (P<0.001). Sonuç olarak, geç laktasyon periyodundaki keçilerde erken laktasyon periyoduna göre lipid peroksidasyonunun azaldığı ve antioksidan savunma sistemi mekanizmasının daha olumlu yönde işlediği kanısına varıldı.

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Section: Discussionmentioning

confidence: 99%

Erken ve Geç Laktasyon Periyodunun Keçilerde Plazma Oksidan/Antioksidan Dengesi Üzerindeki Etkileri

Karapehlivan¹,

Kaya²,

Sağ³

et al. 2013

Kafkas Univ Vet Fak Derg

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“…The significant decrease in GSH, SOD and CAT levels in the cases of liver abscess may be attributed to increased free radical stress in the liver tissue, which inhibits the enzymes activity [38]. It has been reported that increased oxidative stress results in impairment of enzymes containing thiol groups and cell membranes [33,39]. Free radicals can oxidize proteins, the amino acids being oxidized to their hydroxy derivates; for example, phenylalanine can be oxidized to hydroxyphenylalanine, such oxidation can cause enzymatic inactivation [40].…”

Section: Camels With Liver Abscessmentioning

confidence: 99%

Liver Abscess in Dromedary Camels (Camelusdromedaries): Oxidative Stress Biomarkers and Proinflammatory Cytokines

El-Deeb¹,

Fouda²

2013

J Veterinar Sci Technol

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Background: The characteristic clinical manifestations, oxidative stress markers and proinflammatory Cytokines in liver abscess in camel are poorly defined.Objective: Our objectives were to investigate liver abscess in camel at the slaughter house and to address its effect on blood cellular and biochemical values particularly oxidative stress markers and proinflammatory cytokines.Methods: Thirty-five camels with liver abscesses and 15 healthy camels were included in this study. Complete blood picture, and selected biochemical parameters were carried out. Bacteriological examination was also carried out.Results: Clinical signs were recorded. The hematological picture of diseased camels revealed reduction in the total erythrocytic count and hemoglobin level associated with elevation in leucocytic count and neutrophils percentage. The biochemical analysis of serum samples revealed increase in the levels of liver enzymes associated with reduction in the levels of total proteins, albumen and glucose levels in diseased camels when compared to their levels in healthy ones. Increased levels of lipid peroxidation and glucose 6-phosphate dehydrogenase with significant reduction in the levels of superoxide dismutase, catalase and glutathione were evident when compared to their levels in healthy camels. There was elevation in the levels of TNF-α, IFN-γ, IL-1α, IL-1β, IL-6 and IL-10 in diseased camels when compared to their levels in normal ones. The isolated bacteria from liver abscess were Fusobacterium necrophorum, Corynebacterium psuedotuberclosis, Escherichia coli, and Staphylococcus spp. Conclusions:Oxidative stress and proinflammatory Cytokines could be used as biomarkers of liver abscess in camel. It is one of the best antioxidant supplied organs. An important function of the liver is the detoxification of drugs, chemicals and toxic materials, with the subsequent release of free radicals [14,15]. To the best of our knowledge little is known about liver abscess as a disease condition in camels, therefore the main objective of this study was to throw the light on liver abscess in camel at the slaughter house and to address the effects on blood cellular and biochemical values particularly oxidative stress markers and proinflammatory cytokines. Liver Abscesses in Dromedary Camels Materials and Methods AnimalsA total of 50 one-humped camels (Camelus dromedarius) were involved in this study. Their age ranged between 3.5 and 7 years old. All camels were examined carefully before slaughtering. The camels divided into two groups. The 1 st was healthy camels (n=15) and the second was camels with liver abscess (n=35). Journal of Veterinary Science & TechnologyCitation: El-Deeb WM, Fouda TA (2013) Liver Abscesses in Dromedary Camels (Camelus dromedaries): Oxidative Stress Biomarkers and Proinflammatory Cytokines.

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“…Nevertheless, depletion of antioxidant defense mechanisms can impair cellular functions and render hepatocytes more susceptible to the lethal effects of endogenous and exogenous peroxides [20]. Previous studies reported that cows with fatty liver had an increased malondialdhyde production and low plasma and liver α-tocopherol, which indicated increase in the intensity of hepatic lipoperoxidation process and a low antioxidative status [16]. The significant increase in hepatic G6PD activity in cases of fatty degeneration may be attributable to the deposition of fat in the liver.…”

Section: Histopathological Findingsmentioning

confidence: 99%

Glutathion Peroxidase and Glucose-6-Phosphate Dehydrogenase Activities in Bovine Blood and Liver

Ellah

Niishimori

Goryo

et al. 2004

The Journal of Veterinary Medical Science

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ABSTRACT. A total of 46 cattle, including 25 as control, 16 with glycogen degeneration and 5 with severe fatty degeneration were studied. Whole blood and liver tissue specimens were used to measure glutathione peroxidase (GSH-Px) and Glucose-6-Phosphate Dehydrogenase (G6PD) activities. The present study determined the value of these parameters in diagnosing glycogen and fatty degeneration in cattle from the point of the status of antioxidation and lipid peroxidation. The results showed a significant decrease in hepatic GSH-Px activity and a significant increase in hepatic G6PD activity in cases of fatty degeneration. On the other hand, there were no significant changes in erythrocytic and hepatic GSH-Px and G6PD activities in cases of glycogen degeneration. The results indicated lipoperoxidation process in the liver tissues increased in cases of fatty degeneration. Therefore, supplying animals suffering from fatty liver with sufficient quantities of nutrient antioxidants may be valuable when treatment is considered.

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A Study of Lipid Peroxidation and Vitamin E in Dairy Cows with Hepatic Insufficiency

Cited by 52 publications

References 15 publications

Erken ve Geç Laktasyon Periyodunun Keçilerde Plazma Oksidan/Antioksidan Dengesi Üzerindeki Etkileri

Erken ve Geç Laktasyon Periyodunun Keçilerde Plazma Oksidan/Antioksidan Dengesi Üzerindeki Etkileri

Liver Abscess in Dromedary Camels (Camelusdromedaries): Oxidative Stress Biomarkers and Proinflammatory Cytokines

Glutathion Peroxidase and Glucose-6-Phosphate Dehydrogenase Activities in Bovine Blood and Liver

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