Liver Abscess in Dromedary Camels (Camelusdromedaries): Oxidative Stress Biomarkers and Proinflammatory Cytokines

Abstract

Background: The characteristic clinical manifestations, oxidative stress markers and proinflammatory Cytokines in liver abscess in camel are poorly defined.Objective: Our objectives were to investigate liver abscess in camel at the slaughter house and to address its effect on blood cellular and biochemical values particularly oxidative stress markers and proinflammatory cytokines.Methods: Thirty-five camels with liver abscesses and 15 healthy camels were included in this study. Complete blood picture, and selected biochemical parameters were carried out. Bacteriological examination was also carried out.Results: Clinical signs were recorded. The hematological picture of diseased camels revealed reduction in the total erythrocytic count and hemoglobin level associated with elevation in leucocytic count and neutrophils percentage. The biochemical analysis of serum samples revealed increase in the levels of liver enzymes associated with reduction in the levels of total proteins, albumen and glucose levels in diseased camels when compared to their levels in healthy ones. Increased levels of lipid peroxidation and glucose 6-phosphate dehydrogenase with significant reduction in the levels of superoxide dismutase, catalase and glutathione were evident when compared to their levels in healthy camels. There was elevation in the levels of TNF-α, IFN-γ, IL-1α, IL-1β, IL-6 and IL-10 in diseased camels when compared to their levels in normal ones. The isolated bacteria from liver abscess were Fusobacterium necrophorum, Corynebacterium psuedotuberclosis, Escherichia coli, and Staphylococcus spp. Conclusions:Oxidative stress and proinflammatory Cytokines could be used as biomarkers of liver abscess in camel. It is one of the best antioxidant supplied organs. An important function of the liver is the detoxification of drugs, chemicals and toxic materials, with the subsequent release of free radicals [14,15]. To the best of our knowledge little is known about liver abscess as a disease condition in camels, therefore the main objective of this study was to throw the light on liver abscess in camel at the slaughter house and to address the effects on blood cellular and biochemical values particularly oxidative stress markers and proinflammatory cytokines. Liver Abscesses in Dromedary Camels Materials and Methods AnimalsA total of 50 one-humped camels (Camelus dromedarius) were involved in this study. Their age ranged between 3.5 and 7 years old. All camels were examined carefully before slaughtering. The camels divided into two groups. The 1 st was healthy camels (n=15) and the second was camels with liver abscess (n=35). Journal of Veterinary Science & TechnologyCitation: El-Deeb WM, Fouda TA (2013) Liver Abscesses in Dromedary Camels (Camelus dromedaries): Oxidative Stress Biomarkers and Proinflammatory Cytokines.

The diagnostic and prognostic importance of oxidative stress biomarkers and acute phase proteins in Urinary Tract Infection (UTI) in camels

“…Data described in this study provide a reliable biochemical evidence for the generation of circulating oxidative stress as detected by enhanced lipid peroxidation (sMDA and eMDA) and decreased serum levels of the enzymatic (SOD, CAT) and non-enzymatic (GSH) antioxidant markers in dromedary camels suffering UTI. It was reported that MDA levels were increased in a varieties of inflammatory conditions like acute and chronic cystitis in camels ( Abd Ellah, Khamis & Elnisr, 2012 ), UTI in human patients ( Kurutas et al, 2005 ), liver abscess in camels ( El-Deeb & Fouda, 2013 ), mastitis in does ( El-Deeb, 2013 ) pneumonia in calves ( El-Bahr & EL-Deeb, 2013 ). In addition, levels of lipid hydroperoxide were increased in erythrocytes isolated from dairy cows with acute mastitis ( Castillo et al, 2006 ).…”