A study of interferences in glucose measurements in blood by hydrogen peroxide based glucose probes

Palleschi, Giuseppe; Rahni, Mohammad Ali Nabi; Lubrano, G. J.; Ngwainbi, J.Ngeh; Guilbault, George G.

doi:10.1016/0003-2697(86)90315-5

Cited by 90 publications

(28 citation statements)

References 3 publications

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“…In order to avoid these interferences we covered the electrode surface with a cellulose acetate (CA) membrane. This membrane, which is about 100 g mol − 1 MMCO (molar mass cut off), was prepared as previously reported [20][21][22] and was used to assemble biosensors to study such complex matrices as whole blood or foods. The membrane is negatively charged and protects the electrode from protein adsorption and from interfering species such as ascorbic and uric acid.…”

Section: Nitrite Sensor Based On Cellulose Acetate Membranementioning

confidence: 99%

New electrochemical sensors for detection of nitrites and nitrates

Badea

Amine

Palleschi

et al. 2001

Journal of Electroanalytical Chemistry

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143

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Platinum electrodes modified with a cellulose acetate membrane or with poly(1,8-diaminonaphthalene) film were assembled and used for rapid amperometric detection of nitrites and nitrates in water by batch and flow injection analysis.Parameters such as the permeability of the electropolymerised films to nitrites and nitrates, interference effects and recovery studies of these kinds of sensors have been optimised to demonstrate the analytical suitability of the proposed method.Contrary to the standard colorimetric method, which is based on carcinogenic reagents, the amperometric detection of nitrites and nitrates is very simple and rapid and does not require any reagent for nitrite detection. Also, this method could be extended easily to the analysis of nitrites and nitrates in various types of samples such as food, soils, vegetables and fertilisers.

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Section: Nitrite Sensor Based On Cellulose Acetate Membranementioning

confidence: 99%

New electrochemical sensors for detection of nitrites and nitrates

Badea

Amine

Palleschi

et al. 2001

Journal of Electroanalytical Chemistry

Self Cite

143

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“…These membranes (20 mm thick and a nominal MWCO of 100) have been thoroughly studied [42], and have been employed in the assembling of other biosensors for studies in complex matrices as whole blood or foods. They are known to be negatively charged, to protect the electrode from protein adsorption and fouling, and to shield from interferants as ascorbic acid, uric acid, paracetamol.…”

Section: Preparation Of the Homemade Cellulose Acetate Membranes (Nommentioning

confidence: 99%

Amperometric Nitric Oxide Sensors: a Comparative Study

Pallini

Curulli²,

Amine

et al. 1998

Electroanalysis

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A comparative study among different types of modified electrodes for nitric oxide (NO) determination has been carried out. Detection limit, response time, reproducibility and selectivity versus some interferents as ascorbic acid, nitrite and dopamine were evaluated. Platinum (Pt) and glassy carbon (GC) electrodes have been assembled with homemade cellulose acetate membranes, commercially available membranes, Nafion and nonconducting polymers electrosynthesized directly onto the electrode surface. The most interesting results were obtained with a cellulose acetate membrane modified electrode and a Pt/poly[4,4 0 -dihydroxybenzophenone (4,4 0 -DHB)] electrode. The NO probes assembled showed a detection limit of 20 nmol/L and 40 nmol/L, respectively, for the cellulose acetate membrane modified electrode and for the Pt/poly[4,4 0 -dihydroxybenzophenone (4,4 0 -DHB)] electrode. A biological test on washed platelets stimulated by collagen was performed using the Pt/poly(4,4 0 -DHB) electrode.

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“…Using low (100i molecular weight cutoff membranes, Guilbault et al excluded from surfaces interferants other than acetaminophen. 9 Lobel and …”

Section: I 19 Abstract (Continue On Reverse If Necessary and Identmentioning

confidence: 99%

Elimination of electrooxidizable interferant-produced currents in amperometric biosensors

Maidan¹,

Heller

1992

Anal. Chem.

122

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Electrooxidizable ascorbate, urate, and acetaminophen that Interfere with amperometric glucose assays are completely and rapidly oxidized by hydrogen peroxide In a multilayer electrode. The multilayer electrode Is composed of an Immobilized, but not electrically "wired", horseradish peroxidase (HRP) film coated onto a film of electrically "wired" glucose oxidase (GO). The "wired" enzyme Is connected by a redox epoxy network to a vitreous carbon electrode. The current from the electrooxidizable Interferants is decreased by their peroxidase-catalyzed preoxidation by a factor of 2500, and the glucose/lnterferant current ratio Is Increased 101 23 45fold. Undeslred electroreduction of hydrogen peroxide can result when HRP Is also "wired" to the electrode. Such unwanted "wiring" Is prevented by Incorporating an electrically Insulating barrier layer between the wired GO film and the HRP film. The hydrogen peroxide necessary for elimination of Interferants can be added externally, or when this Is not possible, It can be generated In situ by means of a coupled enzyme reaction.

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A study of interferences in glucose measurements in blood by hydrogen peroxide based glucose probes

Cited by 90 publications

References 3 publications

New electrochemical sensors for detection of nitrites and nitrates

New electrochemical sensors for detection of nitrites and nitrates

Amperometric Nitric Oxide Sensors: a Comparative Study

Elimination of electrooxidizable interferant-produced currents in amperometric biosensors

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