A study of hearing function and histopathologic changes in the cochlea of the type 2 diabetes model Tsumura Suzuki obese diabetes mouse

Abstract

The diabetes mice model used in our study showed early age-associated hearing loss, and histopathology showed findings of vessel wall thickening in the modiolus, narrowing of capillaries in the stria vascularis, and chronically reduced blood flow in the cochlea.

Associations between cardiovascular disease and its risk factors with hearing loss—A cross‐sectional analysis

“…The distal part of the cochlea responsible for low‐frequency sound transduction has less capillary vessels and is therefore more sensitive to ischaemia . Histopathological studies on human and mice temporal bones have demonstrated that the cochlea microvasculature undergoes physical degenerative changes in the atherosclerotic patient and diabetic patient . The aim of this study was to determine the association between cardiovascular risk factors and HL.…”

“…[2][3][4] Histopathological studies on human and mice temporal bones have demonstrated that the cochlea microvasculature undergoes physical degenerative changes in the atherosclerotic patient and diabetic patient. 5,6 The aim of this study was to determine the association between cardiovascular risk factors and HL.…”

Effect of Rutin on Diabetic Auditory Neuropathy in an Experimental Rat Model

“…Other clinical and experimental studies have also shown similar effects of diabetes on the hearing threshold. Increased hearing threshold and latency, with changes in wave forms, have been detected in patients with diabetes during ABR recordings [ 7 , 33 , 34 ]. An experimental study showed that the hearing threshold was elevated 5 weeks after diabetes induction in mice.…”

Role of the Stria Vascularis in the Pathogenesis of Sensorineural Hearing Loss: A Narrative Review

“…SNHL often occurs in patients with type 2 diabetes mellitus (T2DM) (Helzner and Contrera, 2016), and the related cochlear histopathological findings include microangiopathy, and degeneration of the SV and outer hair cells (Fukushima et al, 2006;Samocha-Bonet et al, 2021); however, the mechanism underlying pathogenesis remains unclear (Akinpelu et al, 2014). Tsuda et al (2016) observed narrowed capillaries and decreased capillary density in SV in Tsumura Suzuki Obese Diabetes (TSOD) mice, which are regarded as a spontaneous type 2 diabetes model. Intracellular edema, dilatation of the intercellular spaces in intermediate cells of the SV, and moderate degenerative changes in the marginal cells of the SV are prominent findings in the cochlea of Zucker diabetic fatty rats.…”