A Study of Glucose Tolerance and Screening Criteria in 752 Unselected Pregnancies

Wilkerson, Hugh L. C.; O’Sullivan, John B.; Thorner, Robert M.

doi:10.2337/diab.12.4.313

Cited by 35 publications

(13 citation statements)

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“…5 Also, the percentage of mothers delivering heavy babies (26 per cent) is greater than that of 12 per cent reported by Wilkerson and O'Sullivan in their series of 752 unselected pregnancies. 6 No relation between histories suggesting predisposition to diabetes and the occurrence of diabetic glucose tolerance was found in the present patients.…”

Section: Resultsmentioning

confidence: 44%

Observations in Hyperthyroidism of Abnormal Glucose Tolerance and Other Traits Related to Diabetes Mellitus

1965

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Studies were made of glucose tolerance and other characteristics related to diabetes in fifty-one patients with hyperthyroidism. Glucose tolerance compatible with diabetes was present in 57 per cent of patients when toxic and 30 per cent on return to euthyroidism. Histories of family diabetes in both sexes and of heavy babies delivered by the women were obtained more frequently than expected in the general population. Reasons are given to suggest a genetic relation between hyperthyroidism and diabetes. DIABETES 14:740-44, November 1965.The prevalence of diabetes mellitus in clinical hyperthyroidism is not known with certainty. Estimates of 2.0 to 3.3 per cent have been given, figures little different from that expected for genetic diabetes in the general population. 1 Since this frequency seemed lower than that encountered on the Medical Service at the Cincinnati General Hospital, studies were made of glucose tolerance in hyperthyroid patients over a three-year period. In addition, observations were made of other traits related to genetic diabetes mellitus. METHODS(1) Patients. The sample for study included all patients in whom the diagnosis of hyperthyroidism was made by the Medical Service of the Cincinnati General Hospital from 12/1/60 to 11/30/63. There were fortyfour women and seven men. The mean age was fortythree years. The distributions of thyroid disease and ages are given in table 1.(2) Assessment of thyroid function. Hyperthyroidism was diagnosed by symptoms, signs, and appropriate tests. The mean weight loss claimed was twenty-five pounds or 16.5 per cent of pretoxic weight. The mean

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Section: Resultsmentioning

confidence: 44%

Observations in Hyperthyroidism of Abnormal Glucose Tolerance and Other Traits Related to Diabetes Mellitus

1965

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“…9 Any criterion of impaired carbohydrate metabolism during pregnancy has to be arbitrarily defined and standards have traditionally varied widely even among experts. 17 In general, with any screening procedure, a compromise must be reached between sensitivity and specificity in order to provide maximal clinical utility and cost effectiveness.…”

Section: Materials and Methods Resultsmentioning

confidence: 99%

A Pilot Community-Based Screening Program for Gestational Diabetes

et al. 1980

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A pilot community-based screening program for gestational diabetes has been in operation in Cleveland, Ohio, since April 1, 1977. A socioeconomic and racially heterogeneous group of pregnant women are being routinely tested at approximately 24-28 wk of gestation by a capillary whole blood glucose determination, 2-h after a 75-g oral challenge. The results of the first 2225 screenings are analyzed in terms of the variables of maternal race, age, and stage of gestation. The overall incidence of positive screenings (greater than or equal to 120 mg/dl) is shown to be 11.5%, with significantly more positive tests among the whites than the nonwhites. Follow-up oral glucose tolerance testing results in an overall detection rate for abnormal carbohydrate metabolism of 3.1%. The data suggest that a 2-h screening procedure is more efficient than a 1-h procedure in that fewer confirmatory glucose tolerance tests need to be performed in order to yield this rate of detection. It may soon be feasible to introduce such a program on a wider community basis in concert with regionalized perinatal care.

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“…ore than three decades ago, Wilkerson, O'Sullivan, and Mahan (1)(2)(3) initiated studies of glucose intolerance during pregnancy in an effort to identify women at risk for the subsequent development of diabetes. These efforts led to important criteria for the diagnosis of GDM and long-term studies of the population of GDM women identified by these investigators and have clearly confirmed a high risk for the eventual development of diabetes in such subjects.…”

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confidence: 99%

Prepregnancy Weight and Antepartum Insulin Secretion Predict Glucose Tolerance Five Years After Gestational Diabetes Mellitus

et al. 1993

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A Study of Glucose Tolerance and Screening Criteria in 752 Unselected Pregnancies

Cited by 35 publications

References 0 publications

Observations in Hyperthyroidism of Abnormal Glucose Tolerance and Other Traits Related to Diabetes Mellitus

Observations in Hyperthyroidism of Abnormal Glucose Tolerance and Other Traits Related to Diabetes Mellitus

A Pilot Community-Based Screening Program for Gestational Diabetes

Prepregnancy Weight and Antepartum Insulin Secretion Predict Glucose Tolerance Five Years After Gestational Diabetes Mellitus

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