A study of exposure, health effects and mortality of workers engaged in the manufacture and formulation of the insecticides aldrin and dieldrin

Jong, G. de

doi:10.1016/0378-4274(91)90002-n

Cited by 14 publications

(14 citation statements)

References 83 publications

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“…GABA receptors are validated targets for the cyclodienes (such as dieldrin) and phenylpyrazole (such as fipronil) insecticides, which have been used extensively for pest control in agricultural and public health (De Jong, 1991;Narahashi et al, 2010). A resistance mutation, (A301S) (and the alternative substitutions A301G, A301N) that confers resistance to dieldrin and fipronil, has since long been identified and functionally characterised in the protein encoded by Rdl (Resistant to dieldrin) in a wide range of insects (Buckingham et al, 2005;Hansen et al, 2005;Li et al, 2006;Nakao et al, 2010).…”

Section: T Urticae Gaba-gated Chloride Channelsmentioning

confidence: 99%

The cys-loop ligand-gated ion channel gene family of Tetranychus urticae: Implications for acaricide toxicology and a novel mutation associated with abamectin resistance

Dermauw¹,

Ilias²,

Riga³

et al. 2012

Insect Biochemistry and Molecular Biology

177

242

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Section: T Urticae Gaba-gated Chloride Channelsmentioning

confidence: 99%

The cys-loop ligand-gated ion channel gene family of Tetranychus urticae: Implications for acaricide toxicology and a novel mutation associated with abamectin resistance

Dermauw¹,

Ilias²,

Riga³

et al. 2012

Insect Biochemistry and Molecular Biology

177

242

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“…Additionally, it has also been used to control vectors of tropical diseases, including malaria and yellow fever, and also used for industrial purposes to protect electric and telephone cables and to preserve timber materials, etc. (Jong 1991). In the study region, dieldrin is effectively used as soil insecticide, especially for perennial crops, such as palm and banana.…”

Section: Concentration Of Ocps In Watermentioning

confidence: 99%

Anthropogenic nexus on organochlorine pesticide pollution: a case study with Tamiraparani river basin, South India

Kumarasamy

Govindaraj

Vignesh

et al. 2011

Environ Monit Assess

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The levels of 17 organochlorine pesticides residues (OCPs) in surface water and sediments from Tamiraparani river basin, South India were investigated to evaluate their potential pollution and risk impacts. A total of 96 surface water and sediment samples at 12 sampling stations were collected along the river in four seasons during 2008-2009. The ΣOCP concentrations in surface water and sediments were in the range of 0.1 to 79.9 ng l(-1) and 0.12 to 3,938.7 ng g(-1) dry weight (dw), respectively. Among the OCPs, the levels of dichlorodiphenyltrichloroethanes (DDTs), aldrin, dieldrin, cis-chlordane, trans-chlordane, and mirex were dominant in the sediments. The dominant OCPs in water samples are heptachlor, o,p'-DDE, dieldrin, o,p'-DDD, and mirex, which show different source of contamination pattern among sampling seasons. The distribution pattern of DDTs, hexachlorocyclohexane, and other OCPs in the present study shows heterogenic nature of nonpoint source of pollution. Notable contamination of water and sediment sample that was observed in upstream (S2) 58 ng l(-1) and downstream (S11) 1,693 ng g(-1) dw explains agricultural and municipal outfalls, whereas frequent damming effect reduces the concentration level in the midstream. The overall spatial-temporal distribution pattern of ΣOCP residues are illustrated by GIS package.

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“…From these biomonitoring data, the total intake of dieldrin was calculated using the method described in detail by de Jong (1991). In summary, the association between intake and the resulting blood concentration was studied earlier by means of a human volunteer study in which three groups of volunteers ingested doses of 10, 50 or 211 mg of dieldrin daily.…”

Section: Study Populationmentioning

confidence: 99%

“…They were withdrawn from the market for almost all uses in the USA in 1974 and subsequently in other countries. In 1987, production ceased in the last remaining dieldrin and aldrin producing plant at the Royal Dutch/Shell reWnery in Pernis, The Netherlands (de Jong 1991).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, it is the only cohort of its kind where detailed exposure assessment by industrial hygiene data and matching biological monitoring data is available. This exposure assessment was published in detail by de Jong (1991). This study provided data on individual exposures over the years of employment for all subjects who had been employed in the Pernis plants between 1954 (when dieldrin and aldrin production and formulation in this plant began) and 1970.…”

Section: Introductionmentioning

confidence: 99%

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Cancer mortality in workers exposed to dieldrin and aldrin: over 50 years of follow up

Amelsvoort

Slangen

Tsai

et al. 2008

Int Arch Occup Environ Health

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Objective Dieldrin and aldrin, pesticides widely used until the 1970s, have been under suspicion of being carcinogenic. In this study, overall and cause-speciWc mortality was assessed in a cohort of 570 employees occupationally exposed to the pesticides dieldrin and aldrin to investigate the long-term health eVects, in particular carcinogenic eVects. Methods All of the employees worked in the production plants between January 1954 and January 1970 and were followed for cause-speciWc mortality until 30 April 2006. Based on dieldrin levels in blood samples taken from 343 workers during the exposure period, the total intake of dieldrin was estimated for each individual subjects in the cohort. The estimated total intake ranged from 11 to 7,755 mg of dieldrin, with an average of 737 mg. Results Two hundred and twenty-six workers had died before 30 April 2006 compared with an expected number of 327.3, giving a standardized mortality ratio (SMR) of 69.0 (95% conWdence interval (CI): 60.3-78.7). Overall cancer mortality was also signiWcantly lower than expected (SMR: 76.4,). Also, none of the speciWc cancer sites showed a signiWcant excess mortality and no association between exposure level and cancer mortality was found. ConclusionThe results from this study support Wndings from other epidemiological and recent animal studies concluding that dieldrin and aldrin are not likely human carcinogens.

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A study of exposure, health effects and mortality of workers engaged in the manufacture and formulation of the insecticides aldrin and dieldrin

Cited by 14 publications

References 83 publications

The cys-loop ligand-gated ion channel gene family of Tetranychus urticae: Implications for acaricide toxicology and a novel mutation associated with abamectin resistance

The cys-loop ligand-gated ion channel gene family of Tetranychus urticae: Implications for acaricide toxicology and a novel mutation associated with abamectin resistance

Anthropogenic nexus on organochlorine pesticide pollution: a case study with Tamiraparani river basin, South India

Cancer mortality in workers exposed to dieldrin and aldrin: over 50 years of follow up

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