A study of epidemiological, etiological, and clinicopathological factors in periocular hyperpigmentation

Vasudevan, Biju; Chatterjee, Manas; Suwal, Bhabendra; Malik, Ajay

doi:10.4103/pigmentinternational.pigmentinternational_25_17

Cited by 4 publications

(1 citation statement)

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“…Also, as the number of putative depigmenting agents grows there is an increased need for studies to clarify product efficacy, cytotoxicity, topical skin penetration, stability and safety. To add to the complexity, it may be more advantageous to test compounds together to address the synergistic effects on skin lightening, particularly when the active components influence distinct steps of melanogenesis [10]. While it is clear that great progress has been made in the study of skin lightening, it is even more apparent that there is a great deal of work still left to be done.…”

Section: Discussionmentioning

confidence: 99%

"Pigmentation: Exploring the Depths of Hyperpigmentation, Etiology, Pathophysiology and Treatment Modalities"

2024

IRJMETS

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Hyperpigmentation is a common dermatological condition that can have an impact on both one's appearance and one's quality of life. It is distinguished by the presence of a mask-like zone on the skin's surface, which is frequently associated with the development of melasma, ephelides, and lentigines. It can be idiopathic or iatrogenic, and it has been linked to pregnancy, peri-orbital hyperpigmentation, and other skin conditions. This review focuses on the most recent cutting-edge research on the cellular and biochemical mechanisms of melanogenesis, with a particular emphasis on the use of herbal phytoconstituents as a substitute to reduce the likelihood of negative drug reactions and side effects associated with traditional treatments, emphasizing their biodegradability and reducing side effects. In addition to that, the importance of herbal ingredients in acting as potent tyrosinase inhibitors and skin whitening agent is highlighted

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Section: Discussionmentioning

confidence: 99%

"Pigmentation: Exploring the Depths of Hyperpigmentation, Etiology, Pathophysiology and Treatment Modalities"

2024

IRJMETS

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Ferulic acid 12% peel: An innovative peel for constitutional type of periorbital melanosis—Comparing clinical efficacy and safety with 20% glycolic peel and 15% lactic peel

Dayal

Sangal

Sahu

2020

J of Cosmetic Dermatology

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BackgroundPeriorbital hyperpigmentation (POH) is a very common, yet unexplored aesthetic condition. Topical therapy is mainstay of treatment which includes chemical peels and other depigmenting agents.AimsTo compare clinical efficacy, safety, and tolerability of 20% glycolic acid peels, 15% lactic acid peels, and 12% ferulic acid peels in the treatment of constitutional type of periorbital hyperpigmentation in Indian patients.MethodsNinety patients of constitutional POH were enrolled for 12 weeks. They were divided into three groups of 30 each. In 1st group 20% glycolic acid peeling, in 2nd group 15% lactic acid peeling and in 3rd group 12% ferulic acid peeling sessions were performed at 3 weekly intervals. Clinical improvement was assessed objectively using POH grading, physician's and patient's global assessment, and patient's global tolerance.ResultsSignificant improvement in periorbital hyperpigmentation was noted in all the three groups. Physician and patient's global assessment was excellent with glycolic acid peel followed by ferulic acid peel and lactic acid peel. The incidence of side effects in the form of erythema and itching was maximum with glycolic acid followed by lactic acid and least with ferulic acid, which did not necessitate cessation of therapy.ConclusionGlycolic acid produced the best results among the three peels; however, ferulic acid peel emerged as a safe and effective modality for the treatment of POH.

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Classification and characteristics of periorbital hyperpigmentation

Fatin

Sundram

Tan

et al. 2020

Skin Research and Technology

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Introduction: Periorbital hyperpigmentation (POH) is among the commonest esthetic and dermatological complaints. Despite its frequency, there are inadequate information detailing its incidence and prevalence. This subsequently leads to lack of comprehensive POH classification and stratification of impact on an individual's general well-being. Malaysia, a multiracial country with an expansive expatriate population, provides a unique opportunity to identify demographics of POH and subsequently attempts to group this esthetic and dermatological entity. Objective: This study aims to develop a new and clinically relevant POH classification system and to measure impact on quality of life of POH individuals. Methods: One hundred patients with POH were enrolled, of which all underwent clinical assessment by a clinician. Objective assessment with mexameter and digital analysis were performed. All recruited patients also completed a questionnaire based on dermatology life quality index (DLQI). Results: Assessments noted the commonest type of POH among the subjects was vascular (51%) with the least being pigmentary (6%). The location of POH majority involved both the upper and lower eyelids (65%). DLQI scoring shows that a majority (58%) did not disrupt their quality of life. Conclusion: Vascular type POH was the frequent most form observed, and involvement tends to occur on both eyelids. A majority of noted that POH does not affect they QOL, but the due consideration must be given in those whom are moderately and minimally affected. A thorough and comprehensive holistic approach is required in managing POH despite its focal presentation as it does affect a patient's quality of life.

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A study of epidemiological, etiological, and clinicopathological factors in periocular hyperpigmentation

Cited by 4 publications

References 0 publications

"Pigmentation: Exploring the Depths of Hyperpigmentation, Etiology, Pathophysiology and Treatment Modalities"

"Pigmentation: Exploring the Depths of Hyperpigmentation, Etiology, Pathophysiology and Treatment Modalities"

Ferulic acid 12% peel: An innovative peel for constitutional type of periorbital melanosis—Comparing clinical efficacy and safety with 20% glycolic peel and 15% lactic peel

Classification and characteristics of periorbital hyperpigmentation

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