A Study of Electrocatalytic and Photocatalytic Activity of Cerium Molybdate Nanocubes Decorated Graphene Oxide for the Sensing and Degradation of Antibiotic Drug Chloramphenicol

Abstract

In this present work, "killing two birds with one stone" strategy was performed for the electrochemical trace level detection and photocatalytic degradation of antibiotic drug chloramphenicol (CAP) using Ce(MoO) nanocubes/graphene oxide (CeM/GO) composite for the first time. The CeM/GO composite was synthesized via simple hydrothermal treatment followed by sonication process. The successful formation of CeM/GO composite was confirmed by several analytical and spectroscopic techniques. The CeM/GO composite modified glassy carbon electrode (GCE) showed excellent electrocatalytic activity toward the reduction of CAP in terms of decrease the potential and increase the cathodic peak current in comparison with different modified and unmodified electrodes. The electrocatalytic reduction of CAP based on the CeM/GO modified GCE exhibited high selectivity, wide linear ranges, lower detection limit, and good sensitivity of 0.012-20 and 26-272 μM, 2 nM ,and 1.8085 μA μM cm, respectively. Besides, when CeM/GO/GCE was used to analyze the CAP in real samples, such as honey and milk, the satisfactory recovery results were obtained. On the other hand, the CeM/GO composite played excellent catalyst toward the photodegradation of CAP. The obtained results from the UV-vis spectroscopy clearly suggested that CeM/GO composite had high photocatalytic activity compared to pristine Ce(MoO4) nanocubes. The degradation efficiency of CeM/GO toward CAP is observed about 99% within 50 min under visible irradiation and it shows a good stability by observing the reusability of the catalyst. The enhanced photocatalytic performance was attributed to the increased migration efficiency of photoinduced electrons and holes.

The Signal Amplification in Electrochemical Detection of Chloramphenicol Using Sulfonated Polyaniline‐chitosan Composite as Redox Capacitor

“…Chloramphenicol is effective against to a wide variety of bacteria, and has been used in eye drops, topical ointments, various tablets for oral administration and intravenous suspensions . Meanwhile, it is also generally applied for food‐producing animal veterinary medicine, domestic poultry, and aqua‐agriculture farming . However, long‐term intake of a trace of chloramphenicol can make anemia, leucopenia, agranulocytosis and aplastic anemia .…”

“…The prepared electrochemical method exhibited a wider linear detection range and lower detection limit. Moreover, the linear range of this method entirely satisfied the requirement of the European Union , which would potentially apply to general real samples.…”

A facile graphene oxide based sensor for electrochemical detection of prostate anti-cancer (anti-testosterone) drug flutamide in biological samples

“…The presented results suggest that the electrochemical reduction of utamide on the GO modied GCE is an adsorption controlled process. 39…”

Functionalized Carbon Black Nanospheres Hybrid with MoS2 Nanoclusters for the Effective Electrocatalytic Reduction of Chloramphenicol

“…In addition, the reduction peak potential was shifted to negative side at higher scan rates. The negative potential shifts due to the diffusion layer formation . Moreover, the obtained peak current values are plotted against the scan rate values (Figure 5B).…”