A study of diffraction-based chitosan leaky waveguide (LW) biosensors

Goddard, N J

doi:10.1039/d1an00940k

Cited by 10 publications

(12 citation statements)

References 35 publications

(37 reference statements)

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“…3(a) where a dip-peak pair was observed at each resonance angle. 35,36 As two sets of dip-peak were observed, it implies that the chitosan film supported two optical LW modes, which are marked as LW0 and LW1 in Fig. 3(a).…”

Section: Resultsmentioning

confidence: 93%

“…The optical modes are leaky because the RI of chitosan films is lower than glass substrates. 36 The leaky optical modes were coupled in and out of chitosan films on glass substrates using a prism. The observed reflectivity curve is the average of the TE and TM reflectivity curves as unpolarised light was used.…”

Section: Sensors and Diagnostics Papermentioning

confidence: 99%

“…Comparison of leaky waveguides (LWs) reported previously and in this work (in all cases, optical LW mode propagates in z-direction) Diffraction-based leaky waveguides (LWs), 2021 (ref [35][36]. and 2020 (ref 33).…”

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confidence: 91%

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Reflective leaky waveguide gratings (LWGs) with internal referencing for sensing

Goddard

2022

Sens. Diagn.

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Section: Resultsmentioning

confidence: 93%

Section: Sensors and Diagnostics Papermentioning

confidence: 99%

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Reflective leaky waveguide gratings (LWGs) with internal referencing for sensing

Goddard

2022

Sens. Diagn.

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“…LW with a dielectric coating in the form of a porous film that traps biomolecules can increase the sensitivity to refractive index changes by 8–10 times [ 350 ]. In [ 316 ], diffraction-based LWs with chitosan waveguides are studied. The sensor design is very simple, a few microns thick hydrogel film on a glass substrate.…”

Section: Label-free Optical Techniques Of Protein Detection Quantific...mentioning

confidence: 99%

Label-Free Physical Techniques and Methodologies for Proteins Detection in Microfluidic Biosensor Structures

et al. 2022

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Proteins in biological fluids (blood, urine, cerebrospinal fluid) are important biomarkers of various pathological conditions. Protein biomarkers detection and quantification have been proven to be an indispensable diagnostic tool in clinical practice. There is a growing tendency towards using portable diagnostic biosensor devices for point-of-care (POC) analysis based on microfluidic technology as an alternative to conventional laboratory protein assays. In contrast to universally accepted analytical methods involving protein labeling, label-free approaches often allow the development of biosensors with minimal requirements for sample preparation by omitting expensive labelling reagents. The aim of the present work is to review the variety of physical label-free techniques of protein detection and characterization which are suitable for application in micro-fluidic structures and analyze the technological and material aspects of label-free biosensors that implement these methods. The most widely used optical and impedance spectroscopy techniques: absorption, fluorescence, surface plasmon resonance, Raman scattering, and interferometry, as well as new trends in photonics are reviewed. The challenges of materials selection, surfaces tailoring in microfluidic structures, and enhancement of the sensitivity and miniaturization of biosensor systems are discussed. The review provides an overview for current advances and future trends in microfluidics integrated technologies for label-free protein biomarkers detection and discusses existing challenges and a way towards novel solutions.

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“…Chitosan and its bionanocomposites have been introduced as effective immobilization matrix materials. Thus, development of novel devices for early-stage illness diagnosis and biomarker detection were possible through these chitosan-bio-nanocomposites-based biosensors (Figure 8) [142]. Fartas et al have employed graphene/gold nanoparticle/chitosan (GAuCS) nanocomposite films for glucose biosensing.…”

Section: Biosensorsmentioning

confidence: 99%

Recent Advances in Chitin and Chitosan/Graphene-Based Bio-Nanocomposites for Energetic Applications

et al. 2021

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Herein, we report recent developments in order to explore chitin and chitosan derivatives for energy-related applications. This review summarizes an introduction to common polysaccharides such as cellulose, chitin or chitosan, and their connection with carbon nanomaterials (CNMs), such as bio-nanocomposites. Furthermore, we present their structural analysis followed by the fabrication of graphene-based nanocomposites. In addition, we demonstrate the role of these chitin- and chitosan-derived nanocomposites for energetic applications, including biosensors, batteries, fuel cells, supercapacitors and solar cell systems. Finally, current limitations and future application perspectives are entailed as well. This study establishes the impact of chitin- and chitosan-generated nanomaterials for potential, unexplored industrial applications.

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A study of diffraction-based chitosan leaky waveguide (LW) biosensors

Abstract: The waveguide layer of diffraction-based leaky waveguides (LWs) must be made of materials that have low refractive index, are permeable to analytes, can be deposited by spin coating, and can...

Cited by 10 publications

References 35 publications

Reflective leaky waveguide gratings (LWGs) with internal referencing for sensing

Reflective leaky waveguide gratings (LWGs) with internal referencing for sensing

Label-Free Physical Techniques and Methodologies for Proteins Detection in Microfluidic Biosensor Structures

Recent Advances in Chitin and Chitosan/Graphene-Based Bio-Nanocomposites for Energetic Applications

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