A study of Danish snuff‐induced oral leukoplakias

Abstract

Abstract. In a sample of 450 patients with oral leukoplakias, 32 used snuff, which was a Danish wet variety, Göteborg snus ® (Gothenburg Snuff). The group of snuff users consisted of males only, with a mean age of 58.4 years. The mean life exposure time lo snuff was 197,000 hours, the equivalent of 22 years of constant use. Patients with leukoplakia due lo the use of snuff experienced fewer symptoms than did patients with leukoplakia due to other unknown causes. The snuff users also tended to be older at first examination, and to have a higher alcohol intake. Histological changes characteristic of snuff‐users' leukoplakias were: (1) vacuolated cells in the upper part of the spinous cell layers of the epithelium with intervening streaks of parakeratinized cells, (2) epithelial hyperplasia, and (3) hyalinized, eosinophilic deposits around salivary glands. However, statistically significant differences were not found between snuff‐induced leukoplakias and other leukoplakias either as lo dysplasia observed histologically or as to malignant development.

Oral snuff, smoking habits and alcohol consumption in relation to oral cancer in a Swedish case-control study

“…Studies on the histopathology of mucosal reaction have been carried out in the United States (Smith et al, 1970), Denmark (Roed-Peterson and Pindborg, 1973) and Sweden (Andersson et al, 1989;Axell et al, 1976) whereby epithelial changes have been described, but in most cases, such changes were seen in the outermost layers of the mucosa only. Axell et al (1976), in the material of 114 biopsies from current snuff dippers in Sweden, found no cellular atypia or epithelial dysplasia.…”

Chronic Hyperplastic Candidosis/Candidiasis (Candidal Leukoplakia)

“…According to several reports, the leukoplakias that harbor candidal hyphae appear to constitute from 7 to 50% of all leukoplakias (Jepsen and Winther, 1965;Roed-Petersen et al, 1970;Daftary et al, 1972;Roed-Petersen and Pindborg, 1973;Bánóczy, 1982;Krogh et al, 1987b). Lehner (1971) has suggested that differential counts of pyroninophilic monocytes be carried out to distinguish between candidal and non-candidal leukoplakias.…”

Snuff Dipping Sudanese Tombak Keratosis - A Case Report

“…Dysplasia in smokeless tobacco keratosis is quiet rare accounts for less than 3% of cases; which is a condition that precedes and often indicates malignancy potentiality [6,[16][17][18]. A retrospective study in Sweden found only one case of malignant transformation, an extremely low frequency [19].…”