A study of correlation between iron deficiency anaemia and serum lipid profile in Indian adults in BRIMS, Bidar

Antappanavar, Vijaykumar B.; Biradar, Shivraj G.; Patil, V P; Biradar, Prithviraj M.; Mithare, Shivkumar; Sharma, Ashish

doi:10.5455/2349-3933.ijam20140811

Cited by 14 publications

(6 citation statements)

References 11 publications

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“…It is also possible that variation in the serum lipid profile during malaria has a correlation with anaemia. Triglycerides and VLDL were elevated, whereas LDL levels were lower in adult Indian patients with iron deficiency anaemia from BRIMS, Bidar 48 . Although in the present work, anaemia was not detected at 7 d.p.i., we do not rule out that serum lipid alterations could be associated with anaemia in posterior periods of infection in Ext-Ts-treated infected mice.…”

Section: Discussionmentioning

confidence: 90%

Ethanolic extract of the fungus Trichoderma stromaticum decreases inflammation and ameliorates experimental cerebral malaria in C57BL/6 mice

Cariaco

Lima

Sousa

et al. 2018

Sci Rep

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Increased resistance to the first-line treatment against P. falciparum malaria, artemisinin-based combination therapies, has been reported. Here, we tested the effect of crude ethanolic extract of the fungus Trichoderma stromaticum (Ext-Ts) on the growth of P. falciparum NF54 in infected human red blood cells (ihRBCs) and its anti-malarial and anti-inflammatory properties in a mouse model of experimental cerebral malaria. For this purpose, ihRBCs were treated with Ext-Ts and analysed for parasitaemia; C57BL/6 mice were infected with P. berghei ANKA (PbA), treated daily with Ext-Ts, and clinical, biochemical, histological and immunological features of the disease were monitored. It was observed that Ext-Ts presented a dose-dependent ability to control P. falciparum in ihRBCs. In addition, it was demonstrated that Ext-Ts treatment of PbA-infected mice was able to increase survival, prevent neurological signs and decrease parasitaemia at the beginning of infection. These effects were associated with systemically decreased levels of lipids and IFN-γ, ICAM-1, VCAM-1 and CCR5 cerebral expression, preserving blood brain barrier integrity and attenuating the inflammatory lesions in the brain, liver and lungs. These results suggest that Ext-Ts could be a source of immunomodulatory and antimalarial compounds that could improve the treatment of cerebral malaria.

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Section: Discussionmentioning

confidence: 90%

Ethanolic extract of the fungus Trichoderma stromaticum decreases inflammation and ameliorates experimental cerebral malaria in C57BL/6 mice

Cariaco

Lima

Sousa

et al. 2018

Sci Rep

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“…[5] IDA, the most common type of anemia, is an important public health problem because of its complications. [6] Electrolytes such as sodium (Na …”

Section: Introductionmentioning

confidence: 99%

Perturbations of serum electrolyte levels in iron deficiency anemia - A comparative analysis

Rajagopal¹,

Ganesan²,

Abdullah³

et al. 2017

Natl J Physiol Pharm Pharmacol

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“…It is well-known that PCs are necessary for assembly and secretion of VLDL lipoprotein particles from the liver. Notably, in iron deficiency anaemia VLDL levels have been reported to be elevated which was reversible by oral iron intake [ 45 , 46 ]. Increased consumption of PC species to assemble VLDL particles may account for the inverse association observed for transferrin implicating subclinical iron depletion.…”

Section: Discussionmentioning

confidence: 99%

Molecular Fingerprints of Iron Parameters among a Population-Based Sample

et al. 2018

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Iron deficiency is the most frequent deficiency disease and parameters of iron metabolism appear to be linked to major metabolic and cardiovascular diseases. We screened a large set of small molecules in plasma for associations with iron status among apparently healthy subjects to elucidate subclinical profiles which may provide a link between iron status and onset of diseases. Based on mass spectrometry and nuclear magnetic resonance spectroscopy we determined 613 plasma metabolites and lipoprotein subfractions among 820 apparently healthy individuals. Associations between ferritin, transferrin, haemoglobin and myoglobin and metabolite levels were tested by sex-specific linear regression analyses controlling for common confounders. Far more significant associations in women (82 out of 102) compared to men became obvious. The majority of the metabolites associated with serum ferritin and haemoglobin in women comprising fatty acid species, branched-chain amino acid catabolites and catabolites of heme. The latter was also obvious among men. Positive associations between serum transferrin and VLDL and IDL particle measures seen in women were observed in men with respect to serum ferritin. We observed a sexual-dimorphic fingerprint of surrogates of iron metabolism which may provide a link for the associations between those parameters and major metabolic and cardiovascular disease.

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A study of correlation between iron deficiency anaemia and serum lipid profile in Indian adults in BRIMS, Bidar

Cited by 14 publications

References 11 publications

Ethanolic extract of the fungus Trichoderma stromaticum decreases inflammation and ameliorates experimental cerebral malaria in C57BL/6 mice

Ethanolic extract of the fungus Trichoderma stromaticum decreases inflammation and ameliorates experimental cerebral malaria in C57BL/6 mice

Perturbations of serum electrolyte levels in iron deficiency anemia - A comparative analysis

Molecular Fingerprints of Iron Parameters among a Population-Based Sample

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