A Study of Clinical Presentation and Management of Malignant Gastric Outlet Obstruction (Northeast India–Based Single-Centre Experience)

Purkayastha, Joydeep; Bannoth, Srinivas; Kalita, Deepjyoti; Talukdar, Anjan Kumar; Borthakur, Bibhuti Bhusan; Pegu, Niju; Das, Gaurav

doi:10.1007/s13193-019-00963-0

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…Four studies examined outcomes between two types of surgical interventions (59)(60)(61)(62). One study assessed outcomes following open versus laparoscopic gastrojejunostomy (59).…”

Section: Surgery Versus Surgerymentioning

confidence: 99%

“…A separate study analyzed outcomes following noncurative intent gastrectomy versus gastrojejunostomy; in patients undergoing non-curative intent gastrectomy versus gastrojejunostomy, there was improvement in the GOOSS score in most of the patients with acceptable patency rates at the end of 90 days (60). The final study investigated gastric partitioning with gastrojejunostomy or Roux-en-Y versus gastrojejunostomy (61).…”

Section: Surgery Versus Surgerymentioning

confidence: 99%

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Palliative interventions for patients with advanced gastric cancer: a systematic review

Kopecky¹,

Monton²,

Rosman³

et al. 2022

Chin Clin Oncol

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Background: Gastric cancer is the fifth most common cancer and the third leading cause of cancer-related death worldwide. Advanced gastric cancer (AGC) is associated with significant morbidity and mortality and is commonly accompanied by a variety of distressing symptoms. Current National Comprehensive Cancer Network (NCCN) guidelines recommend palliative treatment modalities for patients with AGC and the treatment of AGC patients should be influenced by palliative care principles. The objective of this systematic review was to explore the published literature on palliative interventions for patients with AGC.Methods: We performed a systematic literature search to identify English language studies that investigated interventions to improve or treat the symptoms caused by AGC using PubMed, Embase, and Cochrane Library databases from January 1, 2010 to August 18, 2022. Two independent reviewers performed title and abstract review, followed by full-text review and data abstraction. Overall study quality and risk of bias was assessed using published quality assessment tools.Results: We identified 10,364 studies and included 66 studies published between 2010 and 2022 for final review. Among the studies, quality of life (QoL) metrics were most commonly a secondary outcome.Twenty-three studies addressed the palliative management of bleeding with the use of radiation therapy, surgery, arterial embolization, chemotherapy, or endoscopic interventions. Twenty-two studies addressed the management of obstructive symptoms with endoscopic stenting or surgical interventions. Most of these studies were of moderate quality and included well characterized outcomes focused on symptom reduction.Five studies assessed palliative modalities to reduce the symptomatic burden of intraabdominal ascites; these studies were less well characterized, and on average low quality. Fifteen studies of mixed quality assessed QoL for patients with AGC, with only one study evaluating specialty palliative care consultation. No studies outlined the prevalence or practices of advanced care planning in this patient population. Conclusions: Patients with AGC undergo a variety of interventions aimed at palliating the symptoms associated with their diagnosis and improving their QoL. Future research on palliative interventions for patients with AGC should utilize qualitative methodologies to measure outcomes related to symptom management and QoL, further explore the patient experience of living with AGC, and delineate best practices for advanced care planning in this population.

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“…Four studies examined outcomes between two types of surgical interventions (59)(60)(61)(62). One study assessed outcomes following open versus laparoscopic gastrojejunostomy (59).…”

Section: Surgery Versus Surgerymentioning

confidence: 99%

Section: Surgery Versus Surgerymentioning

confidence: 99%

Palliative interventions for patients with advanced gastric cancer: a systematic review

Kopecky¹,

Monton²,

Rosman³

et al. 2022

Chin Clin Oncol

View full text Add to dashboard Cite

show abstract

The clinical impact of malnutrition on the postoperative outcomes of patients undergoing gastrectomy for gastric cancer: Propensity score matched analysis of 2011–2017 hospital database

Lee

Fan

Hastie

et al. 2021

Clinical Nutrition ESPEN

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Gastric dysplasia causing gastric outlet obstruction

et al. 2021

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Gastric dysplasia signifies the presence of atypical cells in the gastric mucosa, which have not invaded beyond the lamina propria, and it rarely leads to tissue growth large enough to cause gastric outlet obstruction (GOO) to the gastric contents. However, GOO is commonly observed as a first clinical manifestation of advanced invasive gastric cancer in developing countries where patients seek medical care late. The present case highlights the treatment journey of a young woman who presented to us with features of GOO. Her endoscopic and radiological findings revealed a nodular gastric antral thickening causing GOO. An endoscopic biopsy showed features of dysplasia. She underwent distal gastrectomy following discussion in a multidisciplinary tumour board. Histopathological examination of the gastrectomy specimen confirmed dysplasia without any invasion beyond lamina. To the best of our knowledge, this is perhaps the first report of dysplasia of the stomach presenting as GOO.

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A Study of Clinical Presentation and Management of Malignant Gastric Outlet Obstruction (Northeast India–Based Single-Centre Experience)

Cited by 3 publications

References 10 publications

Palliative interventions for patients with advanced gastric cancer: a systematic review

Palliative interventions for patients with advanced gastric cancer: a systematic review

The clinical impact of malnutrition on the postoperative outcomes of patients undergoing gastrectomy for gastric cancer: Propensity score matched analysis of 2011–2017 hospital database

Gastric dysplasia causing gastric outlet obstruction

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