A study of auditory evoked potentials in systemic lupus erythematosus patients

Rezende, Maíra dos Santos da Mata; Iório, Maria Cecília Martinelli

doi:10.1016/s1808-8694(15)30579-6

Cited by 6 publications

(3 citation statements)

References 13 publications

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“…34,37,38 Among these cognitive domains, memory was one of the predominant cognitive domains affected in our NPSLE patients. Previous SLE studies used auditory oddball task as the canonical stimuli in the detection of P300 and were not able to find different P300 amplitude and latency in unselected SLE patients 19 or those with past history of neuropsychiatric involvement 18 compared with healthy controls. Only 1 study on pediatric lupus patients with previous NPSLE revealed higher rate of abnormal P300 in up to 82% of these patients and that P300 predicted future neuropsychiatric involvement when applied together with serum anti-neuronal antibodies.…”

Section: Discussionmentioning

confidence: 87%

“…Thus, studying the different subcomponents of P300, including P300a over frontal/central and P300b over central/parietal regions, may help to map underlying structural and/or functional lesions to certain brain regions. 15 Results from previous studies on SLE patients examining P300 elicited by auditory oddball paradigm were inconsistent, [16][17][18][19][20] and the use of P300 in neuropsychiatric lupus research has not been addressed by the ACR. 21 In this study, we aimed to examine electrophysiological features of P300 using visual oddball paradigm, in addition to the canonical auditory oddball paradigm, in SLE patients who had past history of NPSLE and were diagnosed to have cognitive impairment according to neuropsychological evaluation.…”

Section: Introductionmentioning

confidence: 99%

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Electrophysiological Study on Cognitive Function in Systemic Lupus Erythematosus Patients With Previous Neuropsychiatric Involvement

et al. 2016

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This study aimed to evaluate P300 as an electrophysiological marker of cognitive function in patients with systemic lupus erythematosus (SLE) who had previous neuropsychiatric (NPSLE) involvement and were diagnosed to have cognitive impairment by standard neuropsychological tests. Event-related potentials (ERPs) were assessed by the auditory and visual oddball paradigms. Amplitude and latency of P300 at the frontal (Fz), central (Cz), and parietal (Pz) regions were determined and compared with controls. P300 detection was performed in NPSLE patients with pre-diagnosed cognitive impairment (n = 9), matched SLE patients without previous NPSLE (non-NPSLE) (n = 9), and healthy controls (n = 15). Auditory oddball task did not show any P300 abnormality between groups. Visual oddball task revealed reduced amplitude of P300 over Fz ( P = .002) and Cz ( P = .009) electrodes in NPSLE patients compared with healthy controls and among those who had predominant memory deficit ( P = .01 at Fz). Abnormal P300 was also observed in non-NPSLE patients at Fz and Cz. Using visual oddball paradigm, abnormal P300 was found in NPSLE patients over frontal and parietal regions compared with normal controls but was not discriminative from possible subclinical disease in non-NPSLE patients. In conclusion, visual oddball paradigm was a more sensitive electrophysiological marker than auditory oddball paradigm for cognitive impairment in NPSLE patients.

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Electrophysiological Study on Cognitive Function in Systemic Lupus Erythematosus Patients With Previous Neuropsychiatric Involvement

et al. 2016

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“…In audiology, there is a growing trend of employing both quantitative and qualitative behavioural approaches to diagnose central and/or cognitive auditory issues (20,21). Pure tone audiometry remains the primary method in audiological diagnostics, focusing mainly on peripheral hearing by assessing air and bone auditory thresholds (22). However, the extent of auditory impairment in SLE patients, especially in underdeveloped countries like Pakistan, remains under-researched.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Hearing Impairment Among Systemic Lupus Erythematosus Patients

Cheema,

Khan,

Badar

et al. 2023

JHRR

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Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease with varied manifestations, including potential auditory complications. Previous studies have indicated varying prevalence rates of hearing impairment among SLE patients, necessitating further research to understand the extent and nature of these auditory issues. Objective: The primary aim of this study was to assess the prevalence and characteristics of hearing impairment in SLE patients, with a focus on identifying the types and degrees of hearing loss and associated symptoms like tinnitus and vertigo. Methods: This observational, cross-sectional study involved 38 SLE patients from Sir Ganga Ram Hospital, Lahore, and DHQ Hospital, Bhimber, Kashmir. Participants underwent pure tone audiometry (PTA) to assess hearing impairment. Data were analyzed using SPSS version 24.0, with a focus on qualitative variables like gender, education, and socio-economic status. Patients with SLE-associated co-morbid factors affecting hearing were excluded. Results: The study found a 29% prevalence of hearing impairment among SLE patients, with sensorineural hearing loss being the most common type (21.1%). Conductive hearing loss and mixed hearing loss were observed in 2.6% and 5.3% of patients, respectively. The majority of hearing impairments were of mild to moderate degree. Additionally, 23.7% of patients reported tinnitus, and 18.45% experienced vertigo. Conclusion: The study concludes that hearing impairment, particularly sensorineural hearing loss of a mild to moderate degree, is a significant concern in SLE patients. The findings highlight the need for routine audiological assessments, including PTA and High Frequency Audiometry (HFA), in the management of SLE patients to facilitate early detection and treatment of hearing loss.

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