Auditory function in patients with systemic lupus erythematosus

Maciaszczyk, Katarzyna; Durko, Tomasz; Waszczykowska, Elżbieta; Erkiert‐Polguj, Anna; Pajor, Anna

doi:10.1016/j.anl.2010.04.008

Cited by 50 publications

(53 citation statements)

References 33 publications

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“…Hearing loss may be bilateral or unilateral, slowly progressive, or sudden; it mainly affects high frequencies, mimicking the typical presbycusis pattern, but may also involve low and middle frequencies [15]. Maciaszczyk et al [30] and Roverano et al [18] described progressive, bilateral SNHL involving high frequencies. Khalidi et al [31] reported unilateral SNHL involving mid and high frequencies (500, 1000, 2000, and 3000 Hz) associated with a 16% word discrimination score as demonstrated by speech audiometry.…”

Section: Inner Ear Involvement In Autoimmune Diseasesmentioning

confidence: 99%

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Ralli

D’Aguanno

Stadio

et al. 2018

Journal of Immunology Research

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Immune-mediated inner ear disease can be primary, when the autoimmune response is against the inner ear, or secondary. The latter is characterized by the involvement of the ear in the presence of systemic autoimmune conditions. Sensorineural hearing loss is the most common audiovestibular symptom associated with systemic autoimmune diseases, although conductive hearing impairment may also be present. Hearing loss may present in a sudden, slowly, rapidly progressive or fluctuating form, and is mostly bilateral and asymmetric. Hearing loss shows a good response to corticosteroid therapy that may lead to near-complete hearing restoration. Vestibular symptoms, tinnitus, and aural fullness can be found in patients with systemic autoimmune diseases; they often mimic primary inner ear disorders such as Menière's disease and mainly affect both ears simultaneously. Awareness of inner ear involvement in systemic autoimmune diseases is essential for the good response shown to appropriate treatment. However, it is often misdiagnosed due to variable clinical presentation, limited knowledge, sparse evidence, and lack of specific diagnostic tests. The aim of this review is to analyse available evidence, often only reported in the form of case reports due to the rarity of some of these conditions, of the different clinical presentations of audiological and vestibular symptoms in systemic autoimmune diseases.

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Section: Inner Ear Involvement In Autoimmune Diseasesmentioning

confidence: 99%

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Ralli

D’Aguanno

Stadio

et al. 2018

Journal of Immunology Research

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“…In contrast, a study by Maciaszczyk et al 18 found that SLE patients had poorer hearing thresholds than controls. It is possible that immunosuppressive therapy could mask or inhibit the immune mechanisms that lead to SNHL.…”

Section: Discussionmentioning

confidence: 82%

“…However, an increased prevalence of subclinical or slowly progressive SNHL has been reported in SLE patients. [16][17][18] Based on their audiometric studies, Roverano et al 4 have recommended that audiometric tests be included as part of initial studies in patients with systemic lupus disease.…”

Section: Discussionmentioning

confidence: 99%

Young systemic lupus erythematosus patients with no hearing involvement: 10-year follow up

et al. 2012

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These results supply no evidence for progressive hearing loss in systemic lupus erythematosus patients with no hearing involvement at study commencement. Therefore, we recommend audiometric tests only for systemic lupus erythematosus patients complaining of hearing loss, or for other clinical purposes. It is conceivable that asymptomatic hearing loss could be observed over a more extended follow-up period (i.e. more than 10 years).

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“…Pada telinga mengakibatkan gangguan dengar sensorineural, tinitus, dan vertigo. 1,2 Vaskulitis pada LES merupakan hasil penyimpanan lokal kompleks imun, khususnya antibodi terhadap deoxyribonucleic acid (anti-DNA) pada dinding pembuluh darah. Apabila vaskulitis terdapat pada arteri labirin dan cabangnya pada penderita LES, keadaan tersebut mengakibatkan gangguan pada pendengaran.…”

Section: Pendahuluanunclassified

“…Gangguan dengar pada frekuensi tinggi berhubungan dengan perbedaan tonotopik bagian basal dan apeks dari koklea, seperti daya tahan sel rambut luar, vaskularisasi, dan kelemahan sel rambut basal terhadap radikal bebas yang membuat reseptor bagian basal menjadi lebih sensitif terhadap kerusakan. 1,18 Sesudah diberikan terapi prednison selama 4 minggu, ambang dengar pada frekuensi tinggi mengalami perbaikan. Prednison mempunyai efek anti-inflamasi dan imunosupresif.…”

Section: Pembahasanunclassified

Pengaruh Prednison terhadap Perbaikan Pendengaran Penderita Lupus Eritematosus

Wijana¹,

Mutiara²,

Agustian³

2016

mkb

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AbstrakLupus eritematosus sistemik (LES) merupakan penyakit kronik mengenai multisistem, merupakan gangguan autoimun yang ditandai oleh produksi autoantibodi dan deposisi kompleks imun di jaringan. Manifestasi klinis dapat meliputi berbagai organ termasuk telinga. Pada telinga dapat menimbulkan gangguan dengar, tinitus, dan vertigo. Gangguan dengar terjadi bilateral pada frekuensi tinggi. Prednison merupakan kortikosteroid oral yang memiliki efek glukokortikoid yang bersifat anti-inflamasi dan imunosupresif. Penelitian ini bertujuan mengetahui pengaruh prednison terhadap perbaikan pendengaran penderita LES. Penelitian dilakukan periode Maret-Mei 2013 di Poliklinik Gangguan Dengar dan Bicara, Telinga Hidung Tenggorok Bedah Kepala dan Leher Rumah Sakit Dr. Hasan Sadikin Bandung menggunakan metode quasi-experimental dengan rancangan one group pretestposttest design dan hasilnya dihitung secara statistik menggunakan uji Rank Spearman. Pada 28 subjek pasien LES dilakukan anamnesis, pemeriksaan fisis, laboratorium, audiometri nada murni, timpanometri, dan distortion production otoacoustic emissions. Subjek diberi prednison 1 mg/kgBB/hari (dosis maksimal 60 mg/hari) selama 4 minggu, kemudian dilakukan evaluasi ulang. Sebelum terapi, 26 subjek mengalami gangguan dengar sedang pada frekuensi tinggi, simetris. Sesudah terapi, 24 subjek ambang dengar menjadi normal dan 4 subjek tetap mengalami gangguan dengar (Rs=0,734; p<0,01 Prednisone Effect to on Hearing Status of Systemic Lupus Erythematosus Patients AbstractSystemic lupus erythematosus (SLE) is a chronic, multi-system, autoimmune disorder characterized by the production of autoantibodies and immune complexes deposition in tissue. Clinical manifestations may include skin, mucosa, joints, blood, heart, lungs, kidneys, central nervous system (CNS), immune system, and ears. SLE Iin the ears can caused sensorineural hearing loss, tinnitus, and vertigo. This hearing disorder is commonly bilateral and has high frequencies. Prednisone is an oral corticosteroid with glucocorticoid and mineralocorticoid effects. Glucocorticoids have anti-inflammatory and immunosuppressive effects. The aim of this study was to evaluate the effect of prednisone in improving the degree of hearing loss in patients with SLE. This study was conducted in from March-May 2013, at tThe Hearing and Speech Disorder Clinic of Ear Nose Throat-Head and Neck Surgery, Dr. Hasan Sadikin Hospital Bandung, using quasi-experimental method with pre-post design in which the results were statistically calculated using Rank Spearman test. This study involved 28 subjects who had been diagnosed for SLE. Anamnesis, physical examination, and laboratory test were performed, followed by pure tone audiometry, tympanometry, and distortion product optoacoustic emissions (DPOAE). Subjects were given prednisone 1 mg/kgBW/day with a maximum dose of 6o mg/day. Re-evaluation was performed after 4 weeksof treatment. Before treatment, 26 subjects had mild hearing loss and 2 subjects had symmetric moderate hearing loss at high freque...

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Auditory function in patients with systemic lupus erythematosus

Cited by 50 publications

References 33 publications

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Audiovestibular Symptoms in Systemic Autoimmune Diseases

Young systemic lupus erythematosus patients with no hearing involvement: 10-year follow up

Pengaruh Prednison terhadap Perbaikan Pendengaran Penderita Lupus Eritematosus

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