A Study of Antiinflammatory Activity of Some Novel α‐Amino Naphthalene and β‐Amino Naphthalene Derivatives.

Abstract

A Study of Antiinflammatory Activity of Some Novel α-Amino Naphthalene and β-Amino Naphthalene Derivatives. -A series of naphthalene derivatives bearing azetidinyl-or thiazolidinyl moieties at their αor β-positions is synthesized and evaluated for acute toxicity, antiinflammatory and analgesic activities. Compounds (VIIb), (VIIc) and (VIIIb) are found to possess more potent antiinflammatory activity compared to the standard phenylbutazone. Compound (VIIc) exhibits even better effects than naproxen. In general, the β-substituted naphthalene derivatives possess better biological properties than their α-naphthalene congeners. -(SHARMA*, S.; SINGH, T.; MITTAL, R.; SAXENA, K. K.; SRIVASTAVA, V. K.; KUMAR, A.; Arch. Pharm. (Weinheim, Ger.) 339 (2006) 3, 145-152; Dep. Pharmacol., Lala Lajpat Rai Mem. Med. Coll., Meerut 250 004, India; Eng.) -M. Kowall 28-127

Naphthalene: an overview

“…Therefore, inhibiting and preventing inflammatory processes are significant research objectives (Chang, Liao et al 2017). Currently, the naphthalene derivatives naproxen and nabumetone are utilized to treat inflammatory diseases (Sharma, Singh et al 2006).…”