Naphthalene: an overview

Abstract

In recent years, the discovery, identification, and development of biologically active compounds have gained a lot of importance. Numerous scaffolds have been synthesized using naphthalene, which has also been shown to have a wide range of therapeutic properties, including antimicrobial, antiviral, antiprotozoal, antidiabetic, anticancer, anti-inflammatory, antihypertensive, antipsychotic, antidepressant, anticonvulsant, and anti-neurodegenerative effects. The naphthalene-based compounds Naphyrone, tolnaftate, naftifine, nafcillin, terbinafine, propranolol, nabumetone, nafimidone, naproxen, duloxetine, lasofoxifene, and bedaquiline, among others, have also been approved by the FDA and are being marketed as medicines. Thus, the naphthalene scaffold emerges as an essential building block in drug development due to its wide range of biological activities due to its structural modifications. This review examines the pharmacological properties of various chemically modified naphthalene-based compounds.

The TaCl5-Mediated Reaction of Dimethyl 2-Phenylcyclopropane-1,1-dicarboxylate with Aromatic Aldehydes as a Route to Substituted Tetrahydronaphthalenes

“…The combined organic layers were washed with brine (20 mL), dried over anhydrous MgSO 4 . The reaction mixture was filtered through a filter paper and concentrated in vacuo to give a crude product that was purified by column chromatography (petroleum etherethyl acetate = 6:1) to afford 2a (432 mg, 89%) as colorless crystals: mp, 148-150 • C. 1 (7), 389 (22), 388 (22), 357 (5), 330 (6), 262 (12), 218 (13), 203 (22), 202 (25), 127 (7), 59 (100). Anal.…”

“…This approach is based on the use of TaCl 5 and is demonstrated in Scheme 1 . The tetrahydronaphthalene moiety is a key structural motif in molecules of interest that have diverse biological properties, including anticancer, antimicrobial and antiviral activity [ 21 , 22 ].…”